Stimulation of nerve growth factor and substance P expression in the iris–trigeminal axis of diabetic rats—involvement of oxidative stress and effects of aldose reductase inhibition

1998 ◽  
Vol 802 (1-2) ◽  
pp. 247-253 ◽  
Author(s):  
Paul Fernyhough ◽  
Wendy J. Brewster ◽  
Karin Fernandes ◽  
Lara T. Diemel ◽  
David R. Tomlinson
Keyword(s):  
Oxidative Stress ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Substance P ◽  
Aldose Reductase ◽  
Diabetic Rats ◽  
Nerve Growth ◽  
Aldose Reductase Inhibition ◽  
Stimulation Of Nerve ◽  
Stimulation Of

scholarly journals Spatial Distribution of Nociceptive Neuropeptide and Nerve Growth Factor Depletion in Experimental Diabetic Peripheral Nervous System

2002 ◽  
Vol 30 (5) ◽  
pp. 512-519 ◽  
Author(s):  
H Kanbayashi ◽  
H Itoh ◽  
T Kashiwaya ◽  
K Atoh ◽  
I Makino
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Substance P ◽  
Dorsal Root ◽  
Time Course ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Enzyme Linked Immunosorbent Assay ◽  
Dependent Manner ◽  
Nerve Growth

This study investigated the time-course of the nociceptive neuropeptide substance P and nerve growth factor (NGF), which facilitates substance P production, in lumbar and cervical dorsal root ganglia (DRG) of streptozotocin-induced diabetic rats. Levels of substance P and NGF were measured by radioimmunoassay and sandwich enzyme-linked immunosorbent assay, respectively, 2 months, 4 months and 8 months after induction of diabetes, and compared with age-matched non-diabetic control rats. At 2 months and 4 months, substance P and NGF levels were lower in the lumbar DRG of the diabetic rats than in controls. At 8 months, substance P and NGF were lower in both the lumbar and cervical DRG of the diabetic rats than in controls. These data demonstrate that a decrease in substance P levels in primary sensory neurons with NGF depletion occurs in an axonal length-dependent manner in diabetic rats, and that this decrease may be correlated with the duration of diabetes.

scholarly journals Stimulation of Nerve Growth Factor Synthesis and Secretion by Fellutamide Ain Vitro

1993 ◽  
Vol 57 (2) ◽  
pp. 195-199 ◽  
Author(s):  
Kohji Yamaguchi ◽  
Tomoko Tsuji ◽  
Shinobu Wakuri ◽  
Kazunaga Yazawa ◽  
Kiyosi Kondo ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Nerve Growth ◽  
Stimulation Of Nerve ◽  
Nerve Growth Factor Synthesis ◽  
Stimulation Of

scholarly journals Stimulation of nerve growth factor synthesis/secretion by 1,4-benzoquinone and its derivatives in cultured mouse astroglial cells

FEBS Letters ◽  
1990 ◽  
Vol 261 (1) ◽  
pp. 63-66 ◽  
Author(s):  
Rie Takeuchi ◽  
Katsuhito Murase ◽  
Yoshiko Furukawa ◽  
Shoei Furukawa ◽  
Kyozo Hayashi
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Astroglial Cells ◽  
Nerve Growth ◽  
Stimulation Of Nerve ◽  
Nerve Growth Factor Synthesis ◽  
Stimulation Of

Stimulation of nerve growth factor receptors in PC12 by acetyl-l-carnitine

1992 ◽  
Vol 44 (3) ◽  
pp. 577-585 ◽  
Author(s):  
Giulio Taglialatela ◽  
Luciano Angelucci ◽  
Maria Teresa Ramacci ◽  
Karin Werrbach-Perez ◽  
George R. Jackson ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Growth Factor Receptors ◽  
Nerve Growth ◽  
Nerve Growth Factor Receptors ◽  
Stimulation Of Nerve ◽  
Stimulation Of
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