Towards an understanding of the molecular mechanism of the unimolecular decomposition of the N-chloro-α-amino acids on the ground and excited states surfaces in aqueous medium

1998 ◽  
Vol 283 (5-6) ◽  
pp. 294-300 ◽  
Author(s):  
J.J. Queralt ◽  
V.S. Safont ◽  
V. Moliner ◽  
J. Andrés
Keyword(s):  
Amino Acids ◽  
Aqueous Medium ◽  
Molecular Mechanism ◽  
Excited States ◽  
Unimolecular Decomposition

Reactions of Excited States of Phenoxazin-3-one Dyes with Amino Acids¶

2007 ◽  
Vol 81 (4) ◽  
pp. 884-890
Author(s):  
M. L. Villegas ◽  
S. G. Bertolotti ◽  
C. M. Previtali ◽  
M. V. Encinas
Keyword(s):  
Amino Acids ◽  
Excited States

scholarly journals Insights into genome recoding from the mechanism of a classic +1-frameshifting tRNA

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Howard Gamper ◽  
Haixing Li ◽  
Isao Masuda ◽  
D. Miklos Robkis ◽  
Thomas Christian ◽  
...  
Keyword(s):  
Amino Acids ◽  
Conformational Change ◽  
Molecular Mechanism ◽  
Late Stage ◽  
Anticodon Loop ◽  
Pairing Mechanism ◽  
Extra Nucleotide ◽  
In Cells

AbstractWhile genome recoding using quadruplet codons to incorporate non-proteinogenic amino acids is attractive for biotechnology and bioengineering purposes, the mechanism through which such codons are translated is poorly understood. Here we investigate translation of quadruplet codons by a +1-frameshifting tRNA, SufB2, that contains an extra nucleotide in its anticodon loop. Natural post-transcriptional modification of SufB2 in cells prevents it from frameshifting using a quadruplet-pairing mechanism such that it preferentially employs a triplet-slippage mechanism. We show that SufB2 uses triplet anticodon-codon pairing in the 0-frame to initially decode the quadruplet codon, but subsequently shifts to the +1-frame during tRNA-mRNA translocation. SufB2 frameshifting involves perturbation of an essential ribosome conformational change that facilitates tRNA-mRNA movements at a late stage of the translocation reaction. Our results provide a molecular mechanism for SufB2-induced +1 frameshifting and suggest that engineering of a specific ribosome conformational change can improve the efficiency of genome recoding.

Novel Formation of α-Amino Acids and Their Derivatives from Oxo Acids and Ammonia in an Aqueous Medium

1982 ◽  
Vol 91 (6) ◽  
pp. 2087-2090 ◽  
Author(s):  
Hiroshi YANAGAWA ◽  
Yumiko MAKINO ◽  
Kazuki SATO ◽  
Masato NISHIZAWA ◽  
Fujio EGAMI
Keyword(s):  
Amino Acids ◽  
Aqueous Medium

scholarly journals SYNTHESES OF SUBSTITUTED GUANIDINES

1958 ◽  
Vol 36 (10) ◽  
pp. 1436-1440 ◽  
Author(s):  
Paul E. Gagnon ◽  
Jean L. Boivin ◽  
Joseph Zauhar
Keyword(s):  
Amino Acids ◽  
Aqueous Medium ◽  
Sulphuric Acid ◽  
Metal Salts ◽  
Calcium Cyanamide ◽  
Guanidine Carbonate ◽  
Acid Esters

Ethyl-, propyl-, and benzyl-guanidine nitrates were prepared from amine nitrates and calcium cyanamide or dicyandiamide. Carboxyalkylguanidines were made by condensing the corresponding amino acids with guanidine carbonate in aqueous medium. All the guanidine nitrates, except the benzyl derivative, were converted into the corresponding nitroguanidines by treatment with concentrated sulphuric acid. Esters and metal salts of 1-(α-carboxyalkyl)-2-nitroguanidines were also prepared.

Excited electronic states in dark biological process

1973 ◽  
Vol 6 (4) ◽  
pp. 485-501 ◽  
Author(s):  
G. Cilento
Keyword(s):  
Amino Acids ◽  
Excited States ◽  
Electronic Excitation ◽  
Light Emission ◽  
Biological Process ◽  
Electronic States ◽  
Aromatic Amino Acids ◽  
Active Species ◽  
Excited Electronic States ◽  
Transfer Processes

It is well known that excited states may be generated chemically in biological systems as evidencex and by the phenomenon of bioluminescence and it is natural to suspect that they may also be generated and used in dark processes (Szent-Györgyi, 1941; Steele, 1963; Cilento, 1965; White & Wei, 1970; Whiteet al.1971). Förster (1967) has pointed out that electronic excitation and subsequent transfer processes may occur in biological dark systems despite the fact that the energy available from enzymic processes is too low to excite aromatic amino acids and other biochemical structures. Hastings (1968) suggests that in some organisms light emission is just an alternative to the formation of an active species.

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