Inflammatory bowel disease and male infertility: effects of sulfasalazine and 5-aminosalicylic acid on sperm-fertilizing capacity and reactive oxygen species generation**Supported by Smith Kline & French Laboratories Ltd., Welwyn Garden City, Hertfordshire, United Kingdom.

1989 ◽  
Vol 52 (5) ◽  
pp. 842-845 ◽  
Author(s):  
Frederick C.W. Wu ◽  
R. John Aitken ◽  
Anne Ferguson
Keyword(s):  
Reactive Oxygen Species ◽  
Inflammatory Bowel Disease ◽  
United Kingdom ◽  
Male Infertility ◽  
Bowel Disease ◽  
Reactive Oxygen Species Generation ◽  
Garden City ◽  
Oxygen Species ◽  
Aminosalicylic Acid ◽  
Inflammatory Bowel

scholarly journals Mechanism of action of 5-arninosalicylic acid

1992 ◽  
Vol 1 (3) ◽  
pp. 151-165 ◽  
Author(s):  
N. A. Punchard ◽  
S. M. Greenfield ◽  
R. P. H. Thompson
Keyword(s):  
Rheumatoid Arthritis ◽  
Reactive Oxygen Species ◽  
Inflammatory Bowel Disease ◽  
Mechanism Of Action ◽  
Bowel Disease ◽  
Second Messengers ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Aminosalicylic Acid ◽  
Inflammatory Bowel

5-Aminosalicylic Acid (5-ASA) has been used for over 50 years in the treatment of inflammatory bowel disease in the pro-drug form sulphasalazine (SASP). SASP is also used to treat rheumatoid arthritis. However whether the therapeutic properties of SASP are due to the intact molecule, the 5-ASA or sulphapyridine components is unknown. Several mechanisms of action have been proposed for 5-ASA and SASP including interference in the metabolism of arachidonic acid to prostaglandins and leukotrienes, scavenging,of reactive oxygen species, effects on leucocyte function and production of cytokines. However, it is unlikely that the anti-inflammatory properties of SASP and 5-ASA are due to several different properties but more likely that a single property of 5-ASA explains the theraapeutic effects of 5-ASA and SASP. Reactive oxygen species (ROS) are involved in the metabolism of prostaglandins and leukotrienes and can act as second messengers, and so the scavenging of ROS may be the single mechanism of action of 5-ASA that gives rise to its antiinflammatory effects in both inflammatory bowel disease and rheumatoid arthritis.

Reactive Oxygen Species Scavenging Hollow MnO2 Nanozymes as Carriers Deliver Budesonide for the Synergistic Inflammatory Bowel Disease Therapy

2021 ◽  
Author(s):  
Huiqiang Qiu ◽  
Hengtai Gong ◽  
Yuheng Bao ◽  
Hong Jiang ◽  
Weijun Tong
Keyword(s):  
Reactive Oxygen Species ◽  
Inflammatory Bowel Disease ◽  
Proinflammatory Cytokines ◽  
Bowel Disease ◽  
Active Drug ◽  
Drug Carrier ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Disease Therapy ◽  
Inflammatory Bowel

Inflammatory bowel disease (IBD) is related to excessive reactive oxygen species (ROS) and high expression of proinflammatory cytokines. An enzymatically active drug carrier, which can simultaneously scavenge excessive ROS and...

Expression of nitric oxide synthases and formation of nitrotyrosine and reactive oxygen species in inflammatory bowel disease

1998 ◽  
Vol 186 (4) ◽  
pp. 416-421 ◽  
Author(s):  
Gerard Dijkstra ◽  
Han Moshage ◽  
Hendrik M. Van Dullemen ◽  
Alie de Jager-Krikken ◽  
Anton T. M. G. Tiebosch ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Reactive Oxygen ◽  
Nitric Oxide Synthases ◽  
Oxygen Species ◽  
Inflammatory Bowel

scholarly journals Infliximab Modifies Circulating Reactive Oxygen Species and Restores Serum Antioxidant Potential in Inflammatory Bowel Disease Patients

2011 ◽  
Vol 140 (5) ◽  
pp. S-278
Author(s):  
Luca Pastorelli ◽  
Cristian Testa ◽  
Carlo De Salvo ◽  
Luisa Spina ◽  
Gianeugenio Tontini ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Reactive Oxygen ◽  
Antioxidant Potential ◽  
Oxygen Species ◽  
Inflammatory Bowel

scholarly journals pH and Reactive Oxygen Species‐Sequential Responsive Nano‐in‐Micro Composite for Targeted Therapy of Inflammatory Bowel Disease

2018 ◽  
Vol 28 (50) ◽  
pp. 1806175 ◽  
Author(s):  
Serena Bertoni ◽  
Zehua Liu ◽  
Alexandra Correia ◽  
João Pedro Martins ◽  
Antti Rahikkala ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Inflammatory Bowel Disease ◽  
Targeted Therapy ◽  
Bowel Disease ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Inflammatory Bowel

scholarly journals Reactive Oxygen Species Imaging in a Mouse Model of Inflammatory Bowel Disease

2016 ◽  
Vol 18 (4) ◽  
pp. 473-478 ◽  
Author(s):  
Laura Bronsart ◽  
Linh Nguyen ◽  
Aida Habtezion ◽  
Christopher Contag
Keyword(s):  
Reactive Oxygen Species ◽  
Inflammatory Bowel Disease ◽  
Mouse Model ◽  
Bowel Disease ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Inflammatory Bowel
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