Altered expression of angiogenetic factors in Vegf-Ets-1 cascade in inflammatory bowel disease

2003 ◽  
Vol 124 (4) ◽  
pp. A325
Author(s):  
Konno Shiho ◽  
Iizuka Msahiro ◽  
Sasaki Kenji ◽  
Sato Akiko ◽  
Horie Yasuo ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Altered Expression ◽  
Inflammatory Bowel

scholarly journals Altered expression of cell adhesion molecules in uninvolved gut in inflammatory bowel disease

2008 ◽  
Vol 94 (2) ◽  
pp. 341-347 ◽  
Author(s):  
G. M. SCHUERMANN ◽  
A. E. ABER-BISHOP ◽  
P. FACER ◽  
J. C. LEE ◽  
D. S. RAMPTON ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Bowel Disease ◽  
Cell Adhesion Molecules ◽  
Altered Expression ◽  
Inflammatory Bowel

Altered expression of fucosyl-transferases in inflammatory bowel disease

2001 ◽  
Vol 120 (5) ◽  
pp. A525
Author(s):  
Keith Leiper ◽  
Sameena Javeed ◽  
Yamini Krishna ◽  
Jonathan M. Rhodes ◽  
Barry J. Campbell
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Altered Expression ◽  
Inflammatory Bowel

scholarly journals The Emerging Role of Noncoding RNAs in Pediatric Inflammatory Bowel Disease

2020 ◽  
Vol 26 (7) ◽  
pp. 985-993 ◽  
Author(s):  
Petr Jabandziev ◽  
Julia Bohosova ◽  
Tereza Pinkasova ◽  
Lumir Kunovsky ◽  
Ondrej Slaby ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Expression Profiles ◽  
Significant Proportion ◽  
Noncoding Rnas ◽  
Inflammatory Disorder ◽  
Altered Expression ◽  
Clinical Biomarkers ◽  
Inflammatory Bowel ◽  
Pediatric Ibd

Abstract Prevalence of inflammatory bowel disease (IBD), a chronic inflammatory disorder of the gut, has been on the rise in recent years—not only in the adult population but also especially in pediatric patients. Despite the absence of curative treatments, current therapeutic options are able to achieve long-term remission in a significant proportion of cases. To this end, however, there is a need for biomarkers enabling accurate diagnosis, prognosis, and prediction of response to therapies to facilitate a more individualized approach to pediatric IBD patients. In recent years, evidence has continued to evolve concerning noncoding RNAs (ncRNAs) and their roles as integral factors in key immune-related cellular pathways. Specific deregulation patterns of ncRNAs have been linked to pathogenesis of various diseases, including pediatric IBD. In this article, we provide an overview of current knowledge on ncRNAs, their altered expression profiles in pediatric IBD patients, and how these are emerging as potentially valuable clinical biomarkers as we enter an era of personalized medicine.

Apoptosis in the intestinal mucosa of patients with inflammatory bowel disease: evidence of altered expression of FasL and perforin cytotoxic pathways

2004 ◽  
Vol 20 (3) ◽  
pp. 277-286 ◽  
Author(s):  
Heitor S. P. Souza ◽  
Claudio J. A. Tortori ◽  
Morgana T. L. Castelo-Branco ◽  
Ana Teresa P. Carvalho ◽  
Victor S. Margallo ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Intestinal Mucosa ◽  
Bowel Disease ◽  
Altered Expression ◽  
Inflammatory Bowel

Altered expression of atypical PKC and non-muscle myosin IIA in active and inactive Inflammatory Bowel Disease

2011 ◽  
Vol 17 ◽  
pp. S74
Author(s):  
Flavia Wald ◽  
Radia Forteza ◽  
Runa Diwadkar-Watkins ◽  
Anastasia Mashukova ◽  
Robert Duncan ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Altered Expression ◽  
Atypical Pkc ◽  
Inflammatory Bowel ◽  
Myosin Iia ◽  
Muscle Myosin

Altered expression of angiogenic factors in the VEGF-Ets-1 cascades in inflammatory bowel disease

2004 ◽  
Vol 39 (10) ◽  
pp. 931-939 ◽  
Author(s):  
Shiho Konno ◽  
Masahiro Iizuka ◽  
Michihiro Yukawa ◽  
Kenji Sasaki ◽  
Akiko Sato ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Angiogenic Factors ◽  
Altered Expression ◽  
Inflammatory Bowel

Altered Expression of Interferon-γ and Interleukin-4 in Inflammatory Bowel Disease

1998 ◽  
Vol 4 (4) ◽  
pp. 285-290 ◽  
Author(s):  
Luisa Camoglio ◽  
Anje A. Te Velde ◽  
Albert J. Tigges ◽  
Pranab K. Das ◽  
Sander J. H. Van Deventer
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Interferon Γ ◽  
Interleukin 4 ◽  
Altered Expression ◽  
Inflammatory Bowel

scholarly journals Inflammatory bowel disease is associated with changes of enterocytic junctions

2001 ◽  
Vol 281 (1) ◽  
pp. G216-G228 ◽  
Author(s):  
Nikolaus Gassler ◽  
Claudia Rohr ◽  
Armin Schneider ◽  
Jürgen Kartenbeck ◽  
Alfred Bach ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Inflammatory Process ◽  
Mucosal Barrier ◽  
Altered Expression ◽  
Control Subjects ◽  
Mucosal Tissues ◽  
Associated Proteins ◽  
Junctional Protein ◽  
Inflammatory Bowel

Changes of the intestinal mucosal barrier are considered to play a role in the pathogenesis of inflammatory bowel disease (IBD). Our experiments were designed to identify dysregulation of epithelial junctional molecules in the IBD intestinum and to address whether altered expression of these molecules is a primary event in IBD or a phenomenon secondary to the inflammatory process. Noninflamed and inactively and actively inflamed mucosal tissues from patients with ulcerative colitis or Crohn's disease as well as tissues from control subjects were analyzed for the expression of junctional molecules by different methods. Marked downregulation of junctional proteins and their respective mRNAs was observed in actively inflamed IBD tissues. In IBD tissues with inactive inflammation, only a few junctional molecules such as E-cadherin and α-catenin were affected, whereas expression of desmosomal or tight junction-associated proteins appeared almost unchanged. In noninflamed IBD tissues, junctional protein expression was not different from that seen in normal control subjects. In IBD, downregulation of junctional molecule expression is apparently associated with the inflammatory process and does not likely represent a primary phenomenon.

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