Epidermal growth factor-related peptides (EGF-RPs) regulate somatostatin (SST), histamine, and gastrin secretion in human and rat stomach

2003 ◽  
Vol 124 (4) ◽  
pp. A443 ◽  
Author(s):  
Mitchell L. Schubert ◽  
Robert W. McCuen ◽  
Stephen L. Settle ◽  
Robert J. Coffey
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Rat Stomach ◽  
Gastrin Secretion ◽  
Epidermal Growth

Epidermal growth factor stimulates prostaglandin E release from isolated perfused rat stomach

1982 ◽  
Vol 105 (1) ◽  
pp. 370-374 ◽  
Author(s):  
Tsutomu Chiba ◽  
Yukio Hirata ◽  
Tomohiko Taminato ◽  
Seizo Kadowaki ◽  
Shigeru Matsukura ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Prostaglandin E ◽  
Rat Stomach ◽  
Epidermal Growth ◽  
Prostaglandin E Release

Effect of Epidermal Growth Factor on Rat Stomach Carcinogenesis Induced by N-Methyl-N′-nitro-N-nitrosoguanidine

2008 ◽  
Vol 40 (3) ◽  
pp. 165-171
Author(s):  
Wataru Yasui ◽  
Naoki Takekura ◽  
Takashi Kameda ◽  
Noriko Oda ◽  
Masanori Ito ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Rat Stomach ◽  
Epidermal Growth ◽  
Stomach Carcinogenesis

Modulation of gastrin and epidermal growth factor by pyrrolizidine alkaloids obtained from Senecio brasiliensis in acute and chronic induced gastric ulcers

2004 ◽  
Vol 82 (5) ◽  
pp. 319-325 ◽  
Author(s):  
Walber Toma ◽  
José Roberto Trigo ◽  
Ana Cláudia Bensuaski de Paula ◽  
Alba Regina Monteiro Souza Brito
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Pyrrolizidine Alkaloids ◽  
Gastric Ulcers ◽  
Antiulcer Activity ◽  
Gastrin Secretion ◽  
Epidermal Growth ◽  
Dose Dependent ◽  
Antiulcerogenic Activity

We investigated the antiulcerogenic activity of pyrrolizidine alkaloids (PAs) integerrimine, retrorsine, senecionine, usaramine and seneciplhylline, an alkaloidal extract obtained from Senecio brasiliensis. The PA extract demonstrated significantly activity in both, acute and chronic gastric ulcers on rats. The effects of PA extract were dose dependent. The mechanisms implicated on this activity were evaluated by determination of gastrin plasma levels in rats subjected to the acute treatment with PA extract and by expression of mRNA of Epidermal Growth Factor (EGF) after chronic treatment with this extract. The results showed that the PA extract increased both the levels of gastrin and the expression of EGF on these animals. Moreover, the histological examinations showed a reduction of exfoliation of superficial cells, hemorrhages and blood cell infiltration. We concluded that the PAs showed an important and qualitative antiulcerogenic activity mediated by increase in gastrin secretion and mRNA expression of EGF.Key words: Senecio brasiliensis, pyrrolizidine alkaloids, antiulcer activity, gastrin, EGF.

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