M1621 Gene Expression Profile in Colon Cancer Cells in Response to Troglitazone: Impact of XIAP Expression

2008 ◽  
Vol 134 (4) ◽  
pp. A-384
Author(s):  
Liang Qiao ◽  
Gloria HY Li ◽  
Yun Dai ◽  
Zesong Li ◽  
Bing Zou ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Colon Cancer Cells ◽  
Xiap Expression

Gene expression profile in colon cancer cells with respect to XIAP expression status

2008 ◽  
Vol 24 (3) ◽  
pp. 245-260 ◽  
Author(s):  
Liang Qiao ◽  
Gloria H. Y. Li ◽  
Yun Dai ◽  
Jide Wang ◽  
Zesong Li ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Colon Cancer Cells ◽  
Xiap Expression ◽  
Expression Status

scholarly journals AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells

PPAR Research ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-16 ◽  
Author(s):  
Angelo Cerbone ◽  
Cristina Toaldo ◽  
Stefania Pizzimenti ◽  
Piergiorgio Pettazzoni ◽  
Chiara Dianzani ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colon Cancer ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Combined Treatment ◽  
Colon Cancer Cells ◽  
Positive Interaction ◽  
Anti Inflammatory

PPARαs are nuclear receptors highly expressed in colon cells. They can be activated by the fibrates (clofibrate, ciprofibrate etc.) used to treat hyperlipidemia. Since PPARαtranscriptional activity can be negatively regulated by JNK, the inhibition of JNK activity could increase the effectiveness of PPARαligands. We analysed the effects of AS601245 (a JNK inhibitor) and clofibrate alone or in association, on proliferation, apoptosis, differentiation and the gene expression profile of CaCo-2 human colon cancer cells. Proliferation was inhibited in a dose-dependent way by clofibrate and AS601245. Combined treatment synergistically reduced cell proliferation, cyclin D1 and PCNA expression and induced apoptosis and differentiation. Reduction of cell proliferation, accompanied by the modulation of p21 expression was observed in HepG2 cells, also. Gene expression analysis revealed that some genes were highly modulated by the combined treatment and 28 genes containing PPRE were up-regulated, while clofibrate alone was ineffective. Moreover, STAT3 signalling was strongly reduced by combined treatment. After combined treatment, the binding of PPARαto PPRE increased and paralleled with the expression of the PPAR coactivator MED1. Results demonstrate that combined treatment increases the effectiveness of both compounds and suggest a positive interaction between PPARαligands and anti-inflammatory agents in humans.

scholarly journals Gene expression profile in the activation of subperitoneal fibroblasts reflects prognosis of patients with colon cancer

2015 ◽  
Vol 138 (6) ◽  
pp. 1422-1431 ◽  
Author(s):  
Mitsuru Yokota ◽  
Motohiro Kojima ◽  
Youichi Higuchi ◽  
Yuji Nishizawa ◽  
Akihiro Kobayashi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colon Cancer ◽  
Gene Expression Profile ◽  
Expression Profile
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