M1754 Mortality and Predictors of Prognosis in Culture Positive Spontaneous Bacterial Peritonitis and Culture Negative Neutrocytic Ascites

Objectives: To determine the frequency of culture positive (SBP) and culture negative spontaneous bacterial peritonitis (neutrocytic ascites) in cirrhotic population. Period: The six months (November 08th 2012 to May 07th 2013). Study Design: Descriptive cross-sectional study. Setting: Department of Gastroenterology at Liaquat National Hospital. Total 107 patients of liver cirrhosis with ascites admitted in our hospital. All the specific patients had ascitic fluid DR and C/S were enrolled and evaluated. Patient’s information was recorded on proforma and analyzed by using SPSS-20.0. Results: SBP was detected in 10 7 patients aged between 18 and 67 years included in study. Out of 107 patients with SBP 23 (21.5%) were culture positive while 84 (78.5%) were culture negative. In the culture positive group,19 (82.6%) were male and 4 (17.4%) were female while in culture negative group 46 (54.76%) were male and 38 (45.24%) were female. The ascitic fluid mean total leukocyte count in patients with culture positive ascites was 5140.39 /mm3 and in culture negative ascites was 2654.26 / mm3. The ascitic fluid mean neutrophils count in subjects with culture positive ascites was 75.57% and in culture negative ascites was 76.02%. The ascitic fluid mean lymphocyte count in individuals had culture positive ascites was 26.09 % and in subjects had culture negative ascites was 23.97%. Conclusion: Frequency of culture negative ascites is greater than culture positive ascites in SBP. The ascitic fluid mean total leucocyte count for culture positive ascites is greater than culture negative ascites. Mortality is high in culture positive ascites.

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Culture negative neutrocytic ascites versus culture positive spontaneous bacterial peritonitis; Is there a Difference; A Multi-Centric Study

Medical Journal of Viral Hepatitis ◽

10.21608/mjvh.2021.193408 ◽

2021 ◽

Vol 5.3 (3) ◽

pp. 1-7

Author(s):

Ahmed Yassen ◽

Nasser Mousa ◽

Ahmed Abdel-Razik ◽

Rasha Mahmoud ◽

Alaa Habib ◽

...

Keyword(s):

Spontaneous Bacterial Peritonitis ◽

Bacterial Peritonitis ◽

Culture Positive ◽

Culture Negative

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SPONTANEOUS BACTERIAL PERITONITIS

The Professional Medical Journal ◽

10.29309/tpmj/2006.13.02.5009 ◽

2006 ◽

Vol 13 (02) ◽

pp. 201-205

Author(s):

MUHAMMAD IMRAN ◽

Haroon-ur- Rashid ◽

SHOAIB NAIYAR HASHMI ◽

Assawar Hussain ◽

ASHFAQ ALTAF

Keyword(s):

Ascitic Fluid ◽

Spontaneous Bacterial Peritonitis ◽

Military Hospital ◽

Routine Examination ◽

E Coli ◽

Bacterial Peritonitis ◽

Cirrhotic Patients ◽

The Mean ◽

Culture Positive ◽

Culture Negative

Objective: To evaluate the prevalence, diagnostic criteria and microbialspectrum of spontaneous bacterial peritonitis (SBP) and its variants in cirrhotic patients with ascites. Design: A hospitalbased prospective study carried out in cirrhotic patients with ascites. Place and duration of Study: The study wasconducted in the Department of Medicine Military Hospital Rawalpindi during October 2000 to March 2002. Subjectand Methods: One hundred and eighty consecutive patients of cirrhotic liver between the ages of 20-65 yearspresenting with ascites reporting to outdoor patient department of Military Hospital Rawalpindi were included in thestudy. The diagnosis of cirrhosis was made on history, clinical examination and the ultrasonographic findings. Thesepatients were subjected to ascites fluid tap and the patients were divided into SBP and non-SBP groups in the light ofresults of ascitic fluid routine examination and culture. The SBP group was further categorized into culture positive SBP,culture negative neutrocytic ascites (CNNA) and bacterascites (BA) on the basis of culture results and total leukocytecount, absolute polymorphonuclear leukocyte count per cubic mm of ascitic fluid. Results: The study included 144males and 36 females having cirrhosis with ascites. The mean age of these patients was 52.32±7.87 years. On thebasis of routine examination and culture of tapped ascitic fluid from these cases 57 of 180(31.66%) patients werediagnosed to have SBP or its variants. In addition to classic SBP in 18(31.58%) patients, its variants namely culturenegative neutrocytic ascites and bacterascites were detected in 37(64.92%) and two (3.5%) cases respectively. E. coliwas the most frequently cultured organism. It was isolated in 12 cases of SBP (60%). In 4 cases (20%) Klebsiella wascultured whereas Proteus mirabilus and Streptococcus were reported in two cases (10%) each. Conclusion: This studyindicates that spontaneous bacterial peritonitis is common and potentially fatal complication in cirrhotic patients withascites. E. coli is the most frequent offending organism.

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PWE-132 A re-evaluation of epidemiology and resistance patterns of culture-positive spontaneous bacterial peritonitis in leeds: Abstract PWE-132 Table 1

Gut ◽

10.1136/gutjnl-2015-309861.581 ◽

2015 ◽

Vol 64 (Suppl 1) ◽

pp. A271.1-A271

Author(s):

L Harrison ◽

J Sandoe ◽

M Aldersley ◽

J Jennings

Keyword(s):

Spontaneous Bacterial Peritonitis ◽

Bacterial Peritonitis ◽

Resistance Patterns ◽

Culture Positive

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Third-Generation Cephalosporin-Resistant Spontaneous Bacterial Peritonitis: A single-Centre Experience and Summary of Existing Studies

Canadian Journal of Gastroenterology and Hepatology ◽

10.1155/2014/429536 ◽

2014 ◽

Vol 28 (2) ◽

pp. 83-88 ◽

Cited By ~ 19

Author(s):

Jennifer Chaulk ◽

Michelle Carbonneau ◽

Hina Qamar ◽

Adam Keough ◽

Hsiu-Ju Chang ◽

...

Keyword(s):

Spontaneous Bacterial Peritonitis ◽

Tertiary Care ◽

Generation Cephalosporin ◽

Care Hospital ◽

Third Generation ◽

Bacterial Peritonitis ◽

Common Diagnosis ◽

Cephalosporin Resistance ◽

Third Generation Cephalosporins ◽

Culture Positive

BACKGROUND: Spontaneous bacterial peritonitis (SBP) is the most prevalent bacterial infection in patients with cirrhosis. Although studies from Europe have reported significant rates of resistance to third-generation cephalosporins, there are limited SBP-specific data from centres in North America.OBJECTIVE: To evaluate the prevalence of, predictors for and clinical impact of third-generation cephalosporin-resistant SBP at a Canadian tertiary care centre, and to summarize the data in the context of the existing literature.METHODS: SBP patients treated with both antibiotics and albumin therapy at a Canadian tertiary care hospital between 2003 and 2011 were retrospectively identified. Multivariate logistic regression was used to determine independent predictors of third-generation cephalosporin resistance and mortality.RESULTS: In 192 patients, 25% of infections were nosocomial. Forty per cent (77 of 192) of infections were culture positive; of these, 19% (15 of 77) were resistant to third-generation cephalosporins. The prevalence of cephalosporin resistance was 8% with community-acquired infections, 17% with health care-associated infections and 41% with nosocomial acquisition. Nosocomial acquisition of infection was the only predictor of resistance to third-generation cephalosporins (OR 4.0 [95% CI 1.04 to 15.2]). Thirty-day mortality censored for liver transplantation was 27% (50 of 184). In the 77 culture-positive patients, resistance to third-generation cephalosporins (OR 5.3 [1.3 to 22]) and the Model for End-stage Live Disease score (OR 1.14 [1.04 to 1.24]) were independent predictors of 30-day mortality.CONCLUSIONS: Third-generation cephalosporin-resistant SBP is a common diagnosis and has an effect on clinical outcomes. In an attempt to reduce the mortality associated with resistance to empirical therapy, high-risk subgroups should receive broader empirical antibiotic coverage.

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