Molecular structure of the bile salt export pump gene (Abcb11) reveals a polymorphism between galistone-susceptible and resistant inbred mice

2001 ◽  
Vol 120 (5) ◽  
pp. A1 ◽  
Author(s):  
Anne Figge ◽  
Bšrbel Taenzler ◽  
Beverty J. Paigen ◽  
Siegfried Matern ◽  
Frank Lammert
Keyword(s):  
Molecular Structure ◽  
Bile Salt ◽  
Inbred Mice ◽  
Bile Salt Export Pump

scholarly journals The Bile Salt Export Pump: Molecular Structure, Study Models and Small-Molecule Drugs for the Treatment of Inherited BSEP Deficiencies

2021 ◽  
Vol 22 (2) ◽  
pp. 784
Author(s):  
Muhammad Imran Sohail ◽  
Yaprak Dönmez-Cakil ◽  
Dániel Szöllősi ◽  
Thomas Stockner ◽  
Peter Chiba
Keyword(s):  
Molecular Structure ◽  
Bile Salt ◽  
Intrahepatic Cholestasis ◽  
Treatment Options ◽  
Genetic Diseases ◽  
Structure Study ◽  
Current Treatment ◽  
Bile Salt Export Pump ◽  
Small Molecular Weight

The bile salt export pump (BSEP/ABCB11) is responsible for the transport of bile salts from hepatocytes into bile canaliculi. Malfunction of this transporter results in progressive familial intrahepatic cholestasis type 2 (PFIC2), benign recurrent intrahepatic cholestasis type 2 (BRIC2) and intrahepatic cholestasis of pregnancy (ICP). Over the past few years, several small molecular weight compounds have been identified, which hold the potential to treat these genetic diseases (chaperones and potentiators). As the treatment response is mutation-specific, genetic analysis of the patients and their families is required. Furthermore, some of the mutations are refractory to therapy, with the only remaining treatment option being liver transplantation. In this review, we will focus on the molecular structure of ABCB11, reported mutations involved in cholestasis and current treatment options for inherited BSEP deficiencies.

Loss of bile salt export pump (Bsep/Abcb11) aggravates lipopolysaccharide induced hepatic inflammation in mice

2019 ◽  
Author(s):  
J Remetic ◽  
V Mlitz ◽  
V Kunczer ◽  
H Scharnagl ◽  
T Stojakovic ◽  
...  
Keyword(s):  
Bile Salt ◽  
Bile Salt Export Pump ◽  
Hepatic Inflammation

Bile Salt Export Pump (BSEP/ABCB11): Trafficking and Sorting Disturbances

2013 ◽  
Vol 6 (2) ◽  
pp. 95-103 ◽  
Author(s):  
Hisamitsu Hayashi ◽  
Yuichi Sugiyama
Keyword(s):  
Bile Salt ◽  
Bile Salt Export Pump

scholarly journals Machine Learning Models to Predict Inhibition of the Bile Salt Export Pump

2021 ◽  
Vol 61 (2) ◽  
pp. 587-602
Author(s):  
Kevin S. McLoughlin ◽  
Claire G. Jeong ◽  
Thomas D. Sweitzer ◽  
Amanda J. Minnich ◽  
Margaret J. Tse ◽  
...  
Keyword(s):  
Machine Learning ◽  
Bile Salt ◽  
Bile Salt Export Pump ◽  
Learning Models ◽  
Machine Learning Models

905 OVEREXPRESSION OF THE BILE SALT EXPORT PUMP (ABCB11) IN ABCB4-DEFICIENT MICE AGGRAVATES LIVER FIBROSIS

2011 ◽  
Vol 54 ◽  
pp. S360
Author(s):  
S.N. Weber ◽  
M. Mahler ◽  
V. Plantz ◽  
A. Schmitz ◽  
F. Lammert
Keyword(s):  
Liver Fibrosis ◽  
Bile Salt ◽  
Bile Salt Export Pump ◽  
Deficient Mice

scholarly journals Hypolipidemic agent Z-guggulsterone: metabolism interplays with induction of carboxylesterase and bile salt export pump

2012 ◽  
Vol 53 (3) ◽  
pp. 529-539 ◽  
Author(s):  
Dongfang Yang ◽  
Jian Yang ◽  
Deshi Shi ◽  
Da Xiao ◽  
Yi-Tzai Chen ◽  
...  
Keyword(s):  
Bile Salt ◽  
Bile Salt Export Pump ◽  
Hypolipidemic Agent
Sign in / Sign up

Export Citation Format

Share Document