Defect of Hepatocyte Growth Factor Activator Inhibitor Type1, a Cell Surface Serine Protease Inhibitor, Enhances Intestinal Tumorigenesis in ApcMin/+ Mice

2011 ◽  
Vol 140 (5) ◽  
pp. S-815
Author(s):  
Shinri Hoshiko ◽  
Makiko Kawaguchi ◽  
Kenji Yorita ◽  
Tsuyoshi Fukushima ◽  
Hiroaki Kataoka
Keyword(s):  
Growth Factor ◽  
Cell Surface ◽  
Hepatocyte Growth Factor ◽  
Protease Inhibitor ◽  
Serine Protease Inhibitor ◽  
Intestinal Tumorigenesis ◽  
Hepatocyte Growth Factor Activator ◽  
A Cell ◽  
Hepatocyte Growth ◽  
Activator Inhibitor

scholarly journals Hepatocyte Growth Factor Activator Inhibitor, a Novel Kunitz-type Serine Protease Inhibitor

1997 ◽  
Vol 272 (10) ◽  
pp. 6370-6376 ◽  
Author(s):  
Takeshi Shimomura ◽  
Kimitoshi Denda ◽  
Akiko Kitamura ◽  
Toshiya Kawaguchi ◽  
Masahiro Kito ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Protease Inhibitor ◽  
Serine Protease ◽  
Serine Protease Inhibitor ◽  
Hepatocyte Growth Factor Activator ◽  
Kunitz Type ◽  
Hepatocyte Growth ◽  
Activator Inhibitor

Hepatocyte growth factor activator inhibitor type 2 (HAI-2) modulates hepcidin expression by inhibiting the cell surface protease matriptase-2

2013 ◽  
Vol 450 (3) ◽  
pp. 583-593 ◽  
Author(s):  
Eva Maurer ◽  
Michael Gütschow ◽  
Marit Stirnberg
Keyword(s):  
Growth Factor ◽  
Cell Surface ◽  
Hepatocyte Growth Factor ◽  
Conditioned Medium ◽  
Clinical Importance ◽  
Hepcidin Expression ◽  
Hepatocyte Growth Factor Activator ◽  
Hepatocyte Growth ◽  
Cell Surface Protease ◽  
Activator Inhibitor

Matriptase-2, a recently identified cell surface protease, is the key enzyme of iron homoeostasis modulating the expression of the liver peptide hormone hepcidin. HAI (hepatocyte growth factor activator inhibitor) types 1 and 2 (HAI-1 and HAI-2 respectively) have been shown to inhibit the close homologue, i.e. matriptase. By co-expressing matriptase-2 and the inhibitor HAI-2 we have identified HAI-2 displaying high inhibitory potential against matriptase-2 at the cell surface as well as in conditioned medium. Accordingly, complex formation between matriptase-2 and HAI-2 was demonstrated by isolation of the complex via immobilizing either HAI-2 or matriptase-2 from lysates and conditioned medium of co-expressing cells. Furthermore, HAI-2 indirectly influences the expression of the hepcidin-encoding gene HAMP. The inhibitor abrogates the matriptase-2-mediated suppression of HAMP expression, presumably by inhibiting the supposed potential of matriptase-2 to cleave membrane-bound HJV (haemojuvelin). Taken together, the results of the present study have characterized HAI-2 as an inhibitor of matriptase-2 that modulates the synthesis of hepcidin and provides new insights into the regulatory mechanism of iron homoeostasis, with clinical importance for a treatment of iron overload diseases.

scholarly journals Hepatocyte Growth Factor Activator Inhibitor Type 1 Is a Suppressor of Intestinal Tumorigenesis

2013 ◽  
Vol 73 (8) ◽  
pp. 2659-2670 ◽  
Author(s):  
Shinri Hoshiko ◽  
Makiko Kawaguchi ◽  
Tsuyoshi Fukushima ◽  
Yukihiro Haruyama ◽  
Kenji Yorita ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Intestinal Tumorigenesis ◽  
Hepatocyte Growth Factor Activator ◽  
Inhibitor Type ◽  
Activator Inhibitor Type ◽  
Hepatocyte Growth ◽  
Activator Inhibitor
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