Sa1677 The Polycomb Histone Lysine Methyltransferase EZH2 Controls Interstitial Cell of Cajal Populations by Regulating Stem Cell Differentiation and Self-Renewal

2016 ◽  
Vol 150 (4) ◽  
pp. S343-S344
Author(s):  
Sabriya A. Syed ◽  
Jeong Heon Lee ◽  
Yujiro Hayashi ◽  
Gabriella B. Gajdos ◽  
David T. Asuzu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Interstitial Cell ◽  
Stem Cell Differentiation ◽  
Self Renewal ◽  
Histone Lysine ◽  
Interstitial Cell Of Cajal ◽  
Histone Lysine Methyltransferase ◽  
Lysine Methyltransferase

scholarly journals Activating and inhibitory functions for the histone lysine methyltransferase G9a in T helper cell differentiation and function

2010 ◽  
Vol 207 (5) ◽  
pp. 915-922 ◽  
Author(s):  
Bernhard Lehnertz ◽  
Jeffrey P. Northrop ◽  
Frann Antignano ◽  
Kyle Burrows ◽  
Sima Hadidi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
T Helper ◽  
Trichuris Muris ◽  
Th Cells ◽  
Histone Lysine ◽  
Histone Lysine Methyltransferase ◽  
Lysine Methyltransferase ◽  
And Function

Accumulating evidence suggests that the regulation of gene expression by histone lysine methylation is crucial for several biological processes. The histone lysine methyltransferase G9a is responsible for the majority of dimethylation of histone H3 at lysine 9 (H3K9me2) and is required for the efficient repression of developmentally regulated genes during embryonic stem cell differentiation. However, whether G9a plays a similar role in adult cells is still unclear. We identify a critical role for G9a in CD4+ T helper (Th) cell differentiation and function. G9a-deficient Th cells are specifically impaired in their induction of Th2 lineage-specific cytokines IL-4, IL-5, and IL-13 and fail to protect against infection with the intestinal helminth Trichuris muris. Furthermore, G9a-deficient Th cells are characterised by the increased expression of IL-17A, which is associated with a loss of H3K9me2 at the Il17a locus. Collectively, our results establish unpredicted and complex roles for G9a in regulating gene expression during lineage commitment in adult CD4+ T cells.

scholarly journals Regulation of Gene Expression in Neural Stem Cell Differentiation and Self-Renewal

2015 ◽  
Vol 3 (4) ◽  
pp. 87-98
Author(s):  
Mohammad Reza Hashemzadeh ◽  
Zahra Seyedi ◽  
Mohammad Amin Edalatmanesh ◽  
Samaneh Rafiei ◽  
◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Neural Stem Cell ◽  
Regulation Of Gene Expression ◽  
Stem Cell Differentiation ◽  
Self Renewal

Activating and inhibitory functions for the histone lysine methyltransferase G9a in T helper cell differentiation and function

2010 ◽  
Vol 189 (3) ◽  
pp. i9-i9
Author(s):  
Bernhard Lehnertz ◽  
Jeffrey P. Northrop ◽  
Frann Antignano ◽  
Kyle Burrows ◽  
Sima Hadidi ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
Histone Lysine ◽  
Histone Lysine Methyltransferase ◽  
Lysine Methyltransferase ◽  
And Function

scholarly journals Histone lysine methyltransferase Pr‐set7/SETD8 promotes neural stem cell reactivation

EMBO Reports ◽  
2021 ◽  
Author(s):  
Jiawen Huang ◽  
Mahekta R Gujar ◽  
Qiannan Deng ◽  
Sook Y Chia ◽  
Song Li ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Cell Reactivation ◽  
Histone Lysine ◽  
Histone Lysine Methyltransferase ◽  
Lysine Methyltransferase
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