Mo1767 – Pediatric Onset Inflammatory Bowel Disease is Not Associated with More Disability Compared to Adult Onset Disease

Inflammatory bowel disease is an important pediatric disease, with as many as 25% of cases presenting during childhood. In this article, we review the types, etiology epidemiology, presentation, diagnosis, and management of pediatric inflammatory bowel disease. We also highlight the unique aspects of pediatric-onset inflammatory bowel disease versus adult-onset and future directions in this field, such as the use of genetic studies and ultrasound for the management of pediatric patients with inflammatory bowel disease.

Download Full-text

GENOTYPE AND PHENOTYPE ANALYSIS IN PEDIATRIC-ONSET INFLAMMATORY BOWEL DISEASE AND A COMPARISON TO ADULT-ONSET INFLAMMATORY BOWEL DISEASE

Journal of Pediatric Gastroenterology and Nutrition ◽

10.1097/00005176-200505000-00150 ◽

2005 ◽

Vol 40 (5) ◽

pp. 662

Author(s):

L De. Ridder ◽

PCF Stokkers ◽

MA Benninga ◽

JAJ Taminiau ◽

I Pronk ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Adult Onset ◽

Phenotype Analysis ◽

Inflammatory Bowel ◽

Pediatric Onset

Download Full-text

Colorectal Cancer associated with pediatric inflammatory bowel disease: a case series

BMC Pediatrics ◽

10.1186/s12887-021-02966-9 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Min Jee Kim ◽

Jae Sung Ko ◽

Minsoo Shin ◽

Jong Woo Hahn ◽

Soo Young Moon ◽

...

Keyword(s):

Colorectal Cancer ◽

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Disease Duration ◽

Early Stage ◽

Adult Onset ◽

Increased Risk ◽

Inflammatory Bowel ◽

Surveillance Endoscopy ◽

Pediatric Onset

Abstract Background Inflammatory bowel disease (IBD) is associated with an increased risk of Colorectal cancer (CRC), and its most important risk factors are the duration and extent of the disease. Pediatric-onset inflammatory bowel disease has a tendency for a more extensive, more severe, and longer predicted disease duration than adult-onset inflammatory bowel disease. This study aimed to identify the clinical characteristics of patients with CRC related to pediatric-onset IBD and consider the appropriateness of current surveillance endoscopy recommendations for the detection of premalignant lesions and early-stage CRC. Methods We searched a research platform based on the SUPREME electronic medical record data-mining system to identify cases of colorectal malignancy in patients with pediatric IBD that presented between 2000 and 2020. Results During the follow-up, 4 (1.29 per 1000 person years) out of 443 patients with PIBD was diagnosed with CRC. The median age at diagnosis of CRC was 18.5 (range: 15–24) years, and the median period from diagnosis of IBD to CRC was 9.42 (range: 0.44–11.96) years. The sigmoid colon was the most frequent location of CRC (in 3 of the 4 cases). Adenocarcinoma was the most common histological type (in 2 of the 4 cases). Conclusions Patients with pediatric-onset IBD exhibited a much shorter disease duration than that of adult-onset IBD at the time of diagnosis of CRC, suggesting that surveillance endoscopy for the detection of precancerous lesions and early-stage cancer should be initiated earlier in pediatric patients than in adult patients.

Download Full-text