Su1958 CUMULATIVE RISK OF SURGERY IN PATIENTS WITH ULCERATIVE COLITIS AND CROHN'S DISEASE IN POPULATION-BASED COHORTS: A SYSTEMATIC REVIEW, META-ANALYSIS AND TIME-TREND ANALYSIS

2020 ◽  
Vol 158 (6) ◽  
pp. S-721
Author(s):  
Lester Tsai ◽  
Parambir Dulai ◽  
Larry Prokop ◽  
Vipul Jairath ◽  
William J. Sandborn ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ulcerative Colitis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Trend Analysis ◽  
Time Trend ◽  
Meta Analysis ◽  
Cumulative Risk ◽  
Population Based

Incidence Rates for Surgery in Crohn’s Disease Have Decreased: A Population-based Time-trend Analysis

2020 ◽  
Vol 26 (12) ◽  
pp. 1909-1916 ◽  
Author(s):  
Alexandra E Dittrich ◽  
Reed Taylor Sutton ◽  
Kate Haynes ◽  
Haili Wang ◽  
Richard N Fedorak ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Trend Analysis ◽  
Time Trend ◽  
Population Level ◽  
Population Based ◽  
Incidence Rates ◽  
Annual Percent Change ◽  
Related Data ◽  
Smoking Trends

Abstract Background Many Crohn’s disease (CD) patients will undergo surgery over the course of their life. It is thought that with the introduction of disease-modifying agents like anti-TNF therapy, there would be a population-level decrease in the need for surgery. This time-trend study aimed to assess the changes in surgical rates following the induction of anti-TNF therapy. Methods Adult CD patients who underwent abdominal surgery (identified by administrative coding) between January of 1996 and December of 2013 at 1 of the 4 Edmonton-area hospitals were included. Patient charts were manually reviewed to confirm diagnosis and gather demographic and disease-related data. Population-adjusted annual incidence rates for IBD surgery were calculated by dividing the number of surgeries by estimates for total population of CD patients in Edmonton. Time-trend analysis was conducted to identify change points, calculate annual percent change (APC), and associated 95% confidence intervals (CIs). Results A total of 1410 patients with Crohn’s disease underwent surgery for their disease. The surgical rate decreased by 8.4% each year (95% CI, −9.6% to −7.3%). There was a 36.2% increase in the use of anti-TNF therapy per year (95% CI, 31.3% to 41.5%). Changes in modifiable risk factors for surgery were also seen, including the proportion of active smokers decreasing by 2.2% per year (95% CI, −3.7% to −0.6%). Conclusions Although anti-TNF therapy seems to play a role, the decrease in surgical trends is likely multifactorial, owing to a decline in smoking trends, earlier diagnosis, earlier treatment, improved patient education, and changes in clinical practice.

76 Surgical Resection Rates for Crohn's Disease Are Decreasing: A Population-Based Time Trend Analysis

2016 ◽  
Vol 150 (4) ◽  
pp. S20
Author(s):  
Christopher Ma ◽  
Remo Panaccione ◽  
Gordon W. Moran ◽  
Eric Benchimol ◽  
Steven Heitman ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Trend Analysis ◽  
Surgical Resection ◽  
Time Trend ◽  
Population Based
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