Sa145 VALIDATION OF PHARYNGEAL ACID REFLUX CRITERIA USING HYPOPHARYNGEAL MULTICHANNEL INTRALUMINAL IMPEDANCE-PH

2021 ◽  
Vol 160 (6) ◽  
pp. S-437
Author(s):  
Han-Chung Lien ◽  
Yen-Yang Chen ◽  
Chen-Chi Wang ◽  
Chun-Yi Chuang ◽  
Yung-An Tsou ◽  
...  
Keyword(s):  
Acid Reflux ◽  
Multichannel Intraluminal Impedance ◽  
Intraluminal Impedance ◽  
Hypopharyngeal Multichannel Intraluminal Impedance ◽  
Multichannel Intraluminal Impedance Ph

Strong Intra-Esophageal Reflux May Contribute to the Development of Barrett’s Adenocarcinoma and Affect the Localization

Digestion ◽  
2019 ◽  
Vol 101 (6) ◽  
pp. 752-760
Author(s):  
Masahiro Saito ◽  
Tomoyuki Koike ◽  
Kenichiro Nakagawa ◽  
Yasuaki Abe ◽  
Kazuaki Norita ◽  
...  
Keyword(s):  
Ph Monitoring ◽  
Acid Reflux ◽  
Esophageal Reflux ◽  
Multichannel Intraluminal Impedance ◽  
Weakly Acid ◽  
Intraluminal Impedance ◽  
Total Reflux ◽  
Barrett’S Adenocarcinoma ◽  
Acid Exposure Time ◽  
Multichannel Intraluminal Impedance Ph

<b><i>Background:</i></b> There has been no study that has directly measured the esophageal reflux factors in Barrett’s adenocarcinoma (BA) using 24-h multichannel intraluminal impedance-pH monitoring (24-h MII-pH). We aimed to clarify the esophageal reflux factors in Barrett’s esophagus (BE) and BA and the factors that determine the location of BA with 24-h MII-pH. <b><i>Methods:</i></b> We performed 24-h MII-pH in 26 patients with superficial BA treated endoscopically (BA group) and 13 patients with BE (BE group) and examined the esophageal reflux factors (esophageal acid exposure time [AET], bolus exposure (acid, weakly acid, and alkaline), and number of reflux episodes. In the BA group, there were 16 cases in which the lesions were localized in an area in contact with the esophagogastric junction (EGJ; EGJ group), and 10 cases in which the lesions were proximal to the BE and separated from the EGJ (non-EGJ group). <b><i>Results:</i></b> Total reflux in the bolus exposure in the BA group showed higher values compared to that in the BE group. The total of acid and weakly acid reflux of bolus exposure was significantly higher in the BA group than that in the BE group. The BA group also had greater numbers of total reflux episodes than the BE group. As for the cancer locations in BE, the cases in which the lesions were located proximally and separated from the EGJ had more AET and total reflux and acid reflux indicated by bolus exposure compared to the lesions adjacent to the EGJ. <b><i>Conclusions:</i></b> Stronger gastro-esophageal reflux appeared to be an important factor in the development of adenocarcinoma from BE. In addition, the cancer location in BE may be related to the intensity of esophageal reflux.

Comparison Between Manual and Automated Analyses in Multichannel Intraluminal Impedance: pH Monitoring for Laryngopharyngeal Reflux

2021 ◽  
pp. 019459982110069
Author(s):  
Hee Jin Kang ◽  
Jung Min Park ◽  
Soo Young Choi ◽  
Su Il Kim ◽  
Young Chan Lee ◽  
...  
Keyword(s):  
Laryngopharyngeal Reflux ◽  
Ph Monitoring ◽  
Automated Analysis ◽  
Acid Reflux ◽  
Multichannel Intraluminal Impedance ◽  
Symptom Index ◽  
Manual Analysis ◽  
Intraluminal Impedance ◽  
Symptom Association Probability ◽  
Multichannel Intraluminal Impedance Ph

Objective To evaluate differences between manual and automated analyses of 24-hour multichannel intraluminal impedance–pH monitoring for diagnosis of laryngopharyngeal reflux. Study Design Case series with planned data collection. Setting Academic center outpatient clinic. Methods The study group comprised 127 patients with symptoms suspicious of laryngopharyngeal reflux, who underwent 24-hour multichannel intraluminal impedance–pH monitoring. Automated and manual analyses were performed for each patient. The following parameters were compared between analyses: number of proximal reflux episodes, proximal exposure time, symptom index, and symptom association probability. Results The number of proximal reflux episodes detected by manual analysis was significantly lower than that detected by automated analysis, except in acid reflux cases. The false positive of automated analysis was 39.8%. In addition, the proximal exposure time for manual analysis was significantly lower than that for automated analysis, except in cases of acid reflux. Symptom index and symptom association probability values based on manual analysis were significantly lower than in automated analysis, except in heartburn cases. Conclusions Automated analysis demonstrated a tendency of excessive reflux measurement when compared with manual analysis. It is necessary to increase the accuracy of laryngopharyngeal reflux diagnosis through manual analysis.

“Normal Values of 24H Multichannel Intraluminal Impedance pH-Metry in a Greek Obese Population Based on Montreal Definition of Gerd”

2015 ◽  
Vol 26 (1) ◽  
pp. 126-131 ◽  
Author(s):  
Georgia Doulami ◽  
Stamatina Triantafyllou ◽  
Maria Natoudi ◽  
Konstantinos Albanopoulos ◽  
Evangelos Menenakos ◽  
...  
Keyword(s):  
Normal Values ◽  
Population Based ◽  
Multichannel Intraluminal Impedance ◽  
Intraluminal Impedance ◽  
Obese Population ◽  
Definition Of ◽  
Multichannel Intraluminal Impedance Ph ◽  
Ph Metry

The utility of multichannel intraluminal impedance‐pH testing in tailoring the management of paediatric gastro‐oesophageal reflux disease

2020 ◽  
Vol 109 (12) ◽  
pp. 2799-2807
Author(s):  
Hema Lattha Gunasagaran ◽  
Vincent Varjavandi ◽  
Daniel A. Lemberg ◽  
Chee Y. Ooi ◽  
Nitin Gupta ◽  
...  
Keyword(s):  
Reflux Disease ◽  
Oesophageal Reflux ◽  
Multichannel Intraluminal Impedance ◽  
Oesophageal Reflux Disease ◽  
Intraluminal Impedance ◽  
Multichannel Intraluminal Impedance Ph

scholarly journals Multichannel intraluminal impedance-pH and psychometric properties in gastroesophageal reflux: systematic review

2020 ◽  
Vol 96 (6) ◽  
pp. 673-685
Author(s):  
Emília Silva Gonçalves ◽  
Maíra Seabra de Assumpção ◽  
Maria Fátima Correa Pimenta Servidoni ◽  
Elizete Aparecida Lomazi ◽  
José Dirceu Ribeiro
Keyword(s):  
Systematic Review ◽  
Gastroesophageal Reflux ◽  
Psychometric Properties ◽  
Multichannel Intraluminal Impedance ◽  
Intraluminal Impedance ◽  
Multichannel Intraluminal Impedance Ph

Evaluation and Management of Laryngopharyngeal Reflux Disease: State of the Art Review

2019 ◽  
Vol 160 (5) ◽  
pp. 762-782 ◽  
Author(s):  
Jerome R. Lechien ◽  
Lee M. Akst ◽  
Abdul Latif Hamdan ◽  
Antonio Schindler ◽  
Petros D. Karkos ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Laryngopharyngeal Reflux ◽  
Ph Monitoring ◽  
Diagnosis And Treatment ◽  
Cochrane Library ◽  
Diagnostic Tools ◽  
Multichannel Intraluminal Impedance ◽  
Intraluminal Impedance ◽  
Number Of Patients ◽  
Multichannel Intraluminal Impedance Ph

Objective To review the current literature about the epidemiology, clinical presentation, diagnosis, and treatment of laryngopharyngeal reflux (LPR). Data Sources PubMed, Cochrane Library, and Scopus. Methods A comprehensive review of the literature on LPR epidemiology, clinical presentation, diagnosis, and treatment was conducted. Using the PRISMA statement, 3 authors selected relevant publications to provide a critical analysis of the literature. Conclusions The important heterogeneity across studies in LPR diagnosis continues to make it difficult to summarize a single body of thought. Controversies persist concerning epidemiology, clinical presentation, diagnosis, and treatment. No recent epidemiologic study exists regarding prevalence and incidence with the use of objective diagnostic tools. There is no survey that evaluates the prevalence of symptoms and signs on a large number of patients with confirmed LPR. Regarding diagnosis, an increasing number of authors used multichannel intraluminal impedance–pH monitoring, although there is no consensus regarding standardization of the diagnostic criteria. The efficiency of proton pump inhibitor (PPI) therapy remains poorly demonstrated and misevaluated by incomplete clinical tools that do not take into consideration many symptoms and extralaryngeal findings. Despite the recent advances in knowledge about nonacid LPR, treatment protocols based on PPIs do not seem to have evolved. Implications for Practice The development of multichannel intraluminal impedance–pH monitoring and pepsin and bile salt detection should be considered for the establishment of a multiparameter diagnostic approach. LPR treatment should evolve to a more personalized regimen, including diet, PPIs, alginate, and magaldrate according to individual patient characteristics. Multicenter international studies with a standardized protocol could improve scientific knowledge about LPR.

Time to Stop Blaming Gastroesophageal Reflux

2011 ◽  
Vol 50 (12) ◽  
pp. 1110-1115 ◽  
Author(s):  
Jose M. Garza ◽  
Cade M. Nylund ◽  
Ajay Kaul
Keyword(s):  
Gastroesophageal Reflux ◽  
Retrospective Review ◽  
Acid Reflux ◽  
Acid Suppression ◽  
Multichannel Intraluminal Impedance ◽  
Children's Hospital ◽  
Intraluminal Impedance ◽  
Nonacid Reflux ◽  
Reflux Event ◽  
Children’S Hospital

Objectives. Cough, pain, and desaturation episodes in infants are often ascribed to gastroesophageal reflux, and many are empirically treated with acid suppression medications. The authors hypothesize that most of these symptoms are not related to gastroesophageal reflux. Methods. Retrospective review of 186 combined pH–multichannel intraluminal impedance studies performed in infants at Cincinnati Children’s Hospital. Results. Of 4159 symptoms reported 1504 (36%) were associated with reflux events (27% nonacid and 9% acid). When total number of symptoms and reflux events were taken into consideration, nonacid reflux events were as likely to be associated with a symptom as acid reflux events ( P = .66). Conclusion. The extra-esophageal symptoms commonly attributed to gastroesophageal reflux in infants are most often not associated with a reflux event. Even though causality cannot be definitively proven, in the minority in whom a symptom association is observed, nonacid events are as likely as acid events to cause symptoms.

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