Gastric mucosal blood flow after smoking in healthy human beings assessed by laser Doppler flowmetry

The effect of topical oxymetazoline hydrochloride on the blood flow of the nasal and sinus mucosa of the rabbit was measured by laser-Doppler flowmetry. Oxymetazoline, the active component in clinically used nose drops, induced a dose-dependent decrease of the nasal mucosal blood flow. This effect has previously been shown in humans and suggests the presence of α2–adrenoceptors in the nasal mucosa of the rabbit. Doses of oxymetazoline used clinically in humans induced a 50% reduction of blood flow in rabbits. Rhythmic variations in blood flow were seen in 30% of the rabbits after administration of oxymetazoline. Additionally, oxymetazoline induced a dose-dependent decrease of the mucosal blood flow in the maxillary sinus when the drug was applied in the nose. A vasoconstricting effect of oxymetazoline on the arteries penetrating the maxillary sinus ostium is a possible explanation. This can have positive as well as negative consequences on acute sinus infections.

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Evaluation of mucosal blood flow in portal hypertensive gastropathy using endoscopic laser-doppler flowmetry Department of Internal Medicine and Gastroenterology, University of Bologna ? Italy

Hepatology ◽

10.1016/0270-9139(95)95406-6 ◽

1995 ◽

Vol 22 (4) ◽

pp. A421

Keyword(s):

Internal Medicine ◽

Blood Flow ◽

Laser Doppler Flowmetry ◽

Mucosal Blood Flow ◽

Laser Doppler ◽

Portal Hypertensive Gastropathy ◽

Doppler Flowmetry ◽

Endoscopic Laser

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Limitations of laser-Doppler velocimetry and reflectance spectrophotometry in estimating gastric mucosal blood flow

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.1992.263.5.g810 ◽

1992 ◽

Vol 263 (5) ◽

pp. G810-G815 ◽

Cited By ~ 1

Author(s):

M. Casadevall ◽

J. Panes ◽

J. M. Pique ◽

J. Bosch ◽

J. Teres ◽

...

Keyword(s):

Blood Flow ◽

Gastric Mucosa ◽

Reference Method ◽

Mucosal Blood Flow ◽

Gastric Mucosal Blood Flow ◽

Hydrogen Gas ◽

Laser Doppler ◽

Reflectance Spectrophotometry ◽

Doppler Flowmetry ◽

Normovolemic Anemia

This study investigated the accuracy of laser-Doppler flowmetry (LDV) and reflectance spectrophotometry (RS) measurements as an index of blood flow in the gastric mucosa of the rat, in experimental conditions such as pharmacologically induced vasoconstriction, hypoxia, hyperoxia, and acute normovolemic anemia. Hydrogen gas clearance was used as a reference method. After vasopressin infusion, LDV signal and indexes of hemoglobin (IHb) and oxygen (ISO2) content in the gastric mucosa estimated by RS significantly decreased in parallel with the reduction of gastric mucosal blood flow (GMBF). Neither hypoxia (5% O2 administration) nor hyperoxia (100% O2) affected GMBF or LDV signal. However, both IHb and ISO2 significantly decreased or increased after hypoxia or hyperoxia, respectively. Acute normovolemic anemia induced a significant increase in GMBF, while LDV signal and ISO2 remained unchanged. IHb significantly decreased in linear relationship with the decrements in the hematocrit. It is concluded that 1) in pharmacologically induced GMBF changes, LDV and RS correlate with GMBF; 2) when changes in hemoglobin saturation are induced, LDV but not RS reflects GMBF; and 3) in acute normovolemic anemia, neither LDV nor RS reflects changes in GMBF.

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Sternal blood flow during coronary artery bypass surgery – An experimental study using laser doppler flowmetry

The Thoracic and Cardiovascular Surgeon ◽

10.1055/s-2004-816606 ◽

2004 ◽

Vol 52 (S 1) ◽

Author(s):

M Dudda ◽

MK Fritz ◽

C Wingenfeld ◽

G Muhr ◽

AM Laczkovics

Keyword(s):

Experimental Study ◽

Blood Flow ◽

Coronary Artery ◽

Coronary Artery Bypass ◽

Laser Doppler Flowmetry ◽

Coronary Artery Bypass Surgery ◽

Bypass Surgery ◽

Artery Bypass ◽

Laser Doppler ◽

Doppler Flowmetry

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Peculiarities of microcirculation in periodont tissues in children of key age groups sufficient type 1 diabetes. Part II

Periodontology ◽

10.33925/1683-3759-2019-24-2-108-119 ◽

2019 ◽

Vol 24 (2) ◽

pp. 108-119 ◽

Cited By ~ 2

Author(s):

B. N. Davydov ◽

D. A. Domenyuk ◽

S. V. Dmitrienko

Keyword(s):

Diabetes Mellitus ◽

Blood Flow ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Laser Doppler Flowmetry ◽

Laser Doppler ◽

Diabetic Microangiopathy ◽

Healthy Children ◽

Doppler Flowmetry

Relevance. Morpho-functional changes in peripheral circulation established in type 1 diabetes mellitus correlate with changes in central hemodynamics, allowing the use of microcirculation indicators as diagnostic and prognostic criteria for assessing the degree of functional vascular disorders. Identifcation of microcirculation features of the blood by the method of laser Doppler ﬂowmetry in children with diﬀerent experience of type 1 diabetes in key age categories.Materials and methods. The study included 67 children with type 1 diabetes mellitus aged 12-15 years with an experience of the disease from six months to ten years. The comparison group consisted of 38 healthy children. The state of the microvasculature was assessed by laser Doppler ﬂowmetry using a laser analyzer for capillary blood ﬂow LAKK-OP.Results. In children with an experience of type 1 diabetes of less than two years, microcirculation disorders in periodontal tissues correspond to the hyperemic form, accompanied by increased perfusion, a decrease in the amplitude of low-frequency oscillations, increased heart rate, high blood flling, and blood ﬂow bypass. For children with an endocrinopathy experience of more than three years, microcirculation disorders correspond to a stagnant form, combined with a decrease in perfusion due to stagnation of blood in the venular link, endothelial domination with suppression of neurogenic and cardiac ﬂuctuations, low efciency and redistribution of blood ﬂow in favor of the nutritive link.Conclusions. With the increase in experience, the degree of compensation of type 1 diabetes, the progression of diabetic microangiopathy, it is advisable to designate two stages of development of microcirculatory disorders. Early – compensatory with active adaptation, including neurogenic and endothelial regulation mechanisms. Late – decompensation with passive adaptation, supporting the eﬀectiveness of microcirculation due to myogenic control of regulation, shunting and increasing the rate of blood outﬂow.

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