Analysis of the postulated interaction between the angiotensin II sub-type 1 receptor gene A1166C polymorphism and the insertion/deletion polymorphism of the angiotensin converting enzyme gene on risk of myocardial infarction

2001 ◽  
Vol 154 (1) ◽  
pp. 123-128 ◽  
Author(s):  
R Steeds
Keyword(s):  
Myocardial Infarction ◽  
Angiotensin Ii ◽  
Angiotensin Converting Enzyme ◽  
Receptor Gene ◽  
Angiotensin Converting Enzyme Gene ◽  
Converting Enzyme ◽  
Deletion Polymorphism ◽  
Enzyme Gene ◽  
A1166c Polymorphism

scholarly journals Angiotensin-converting enzyme gene insertion/deletion polymorphism in Indian patients with myocardial infarction

2014 ◽  
Vol 66 ◽  
pp. S13-S14
Author(s):  
C. Anbarasan ◽  
M. Bavanilatha ◽  
N. Radhakrishnan ◽  
S. Vijayakumar ◽  
K. Latchumanadhas ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Angiotensin Converting Enzyme ◽  
Angiotensin Converting Enzyme Gene ◽  
Converting Enzyme ◽  
Deletion Polymorphism ◽  
Enzyme Gene ◽  
Gene Insertion ◽  
Indian Patients

Renin-Angiotensin System Polymorphisms and Coronary Artery Surgery Patients

2005 ◽  
Vol 13 (2) ◽  
pp. 153-156 ◽  
Author(s):  
Kanat Ozisik ◽  
Muge Misirlioglu ◽  
Tulga A Ulus ◽  
Serdar Tuncer ◽  
Mustafa Emir ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Angiotensin Ii ◽  
Angiotensin Converting Enzyme ◽  
Artery Bypass ◽  
Angiotensin Converting Enzyme Gene ◽  
Converting Enzyme ◽  
Enzyme Gene ◽  
Gene Insertion ◽  
Group 2

The frequencies of angiotensin-converting enzyme gene insertion/deletion, angiotensinogen-M253T, and angiotensin II type 1 receptor-A1166C polymorphisms were analyzed in 105 patients undergoing coronary artery bypass grafting (group 1) and a control group of 105 non-cardiac patients (group 2). Blood samples were obtained for biochemical analyses and DNA extraction. Genotyping was performed by polymerase-chain-reaction-based restriction analysis. According to the angiotensin-converting enzyme gene insertion/deletion polymorphism, 36.3% of patients in group 1 and 30.7% in group 2 were homozygous for the DD allele. This difference was not statistically significant. Angiotensin II type 1 receptor-A1166C genotype polymorphism was also not significantly different between the groups. The results showed the angiotensinogen-M235T polymorphism to be heterogenous. The MM homozygote frequency was significantly higher in controls (72.3%), whereas 80% of the TT homozygote frequency was in the surgical group ( p = 0.001). These results show that although there were no significant differences in angiotensin-converting enzyme gene insertion/deletion and angiotensin II type 1 receptor-A1166C genotype polymorphisms between the groups, angiotensinogen-M235T polymorphism of TT homozygote frequency was significantly associated with patients undergoing coronary artery bypass surgery.

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