Structure and function of the class B type I scavenger receptor, SR-BI, an HDL and LDL receptor which mediates selective lipid uptake

2000 ◽  
Vol 151 (1) ◽  
pp. 240
Author(s):  
Monty Krieger
Keyword(s):  
Scavenger Receptor ◽  
Ldl Receptor ◽  
Structure And Function ◽  
Type I ◽  
Lipid Uptake ◽  
Class B ◽  
And Function ◽  
Selective Lipid Uptake

Quercetin induces the selective uptake of HDL-cholesterol via promoting SR-BI expression and the activation of the PPARγ/LXRα pathway

2018 ◽  
Vol 9 (1) ◽  
pp. 624-635 ◽  
Author(s):  
Kun Ren ◽  
Ting Jiang ◽  
Guo-Jun Zhao
Keyword(s):  
Reverse Cholesterol Transport ◽  
Scavenger Receptor ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Cholesterol Transport ◽  
Type I ◽  
Lipid Uptake ◽  
Scavenger Receptor Class ◽  
Class B ◽  
Selective Lipid Uptake

Reverse cholesterol transport (RCT) is the process to deliver cholesterol to the liver for further excretion and involves scavenger receptor class B type I (SR-BI)-mediated selective lipid uptake (SLU) from high-density lipoprotein cholesterol (HDL-C).

Effects of Berberine on Expression of LOX-1 and SR-BI in Human Macrophage-Derived Foam Cells Induced by ox-LDL

2010 ◽  
Vol 38 (06) ◽  
pp. 1161-1169 ◽  
Author(s):  
Siming Guan ◽  
Bin Wang ◽  
Wei Li ◽  
Jinghuan Guan ◽  
Xin Fang
Keyword(s):  
Scavenger Receptor ◽  
Ldl Receptor ◽  
Foam Cells ◽  
Time Dependent ◽  
Human Macrophage ◽  
Type I ◽  
Dependent Manner ◽  
Atp Binding Cassette Transporter ◽  
Abca1 Expression ◽  
Class B

This study investigates the effects of beriberine on the expression of lectin-like ox-LDL receptor-1 (LOX-1), scavenger receptor A (SR-A), SR class B type I (SR-BI) and ATP-binding cassette transporter A1 (ABCA1) in human macrophage-derived foam cells induced by ox-LDL. Different concentrations of Berberine were co-cultured with THP-1 derived foam cells. The mRNA and protein expressions of LOX-1, SR-A, SR-BI and ABCA1 were determined by RT-PCR and Western blot analysis, respectively. Ox-LDL significantly increased the expression of LOX-1 and inhibited the expression of SR-BI in a dose- and time-dependent manner. Berberine significantly inhibited the effects of ox-LDL in a dose- and time-dependent manner. Moreover, ox-LDL significantly promoted ABCA1 expression. However, berberine had no effect on SR-A or ABCA1 expression. Berberine can inhibit the expression of LOX-1 and promote the expression of SR-BI in macrophage-derived foam cells. Therefore, berberine could be used to treat atherosclerotic diseases.

scholarly journals Regulation of Expression and Function of Scavenger Receptor Class B, Type I (SR-BI) by Na+/H+Exchanger Regulatory Factors (NHERFs)

2013 ◽  
Vol 288 (16) ◽  
pp. 11416-11435 ◽  
Author(s):  
Zhigang Hu ◽  
Jie Hu ◽  
Zhonghua Zhang ◽  
Wen-Jun Shen ◽  
C. Chris Yun ◽  
...  
Keyword(s):  
Scavenger Receptor ◽  
Type I ◽  
Regulation Of Expression ◽  
Regulatory Factors ◽  
Scavenger Receptor Class ◽  
Class B ◽  
And Function
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