scholarly journals Transcription factor (TF) IIB and TFIIA can independently increase the affinity of the TATA-binding protein for DNA.

1994 ◽  
Vol 269 (11) ◽  
pp. 8280-8286
Author(s):  
A.N. Imbalzano ◽  
K.S. Zaret ◽  
R.E. Kingston
Keyword(s):  
Transcription Factor ◽  
Binding Protein ◽  
Tata Binding Protein

scholarly journals Transcription Factor IIA Derepresses TATA-binding Protein (TBP)-associated Factor Inhibition of TBP-DNA Binding

1998 ◽  
Vol 273 (23) ◽  
pp. 14293-14300 ◽  
Author(s):  
Josef Ozer ◽  
Katherine Mitsouras ◽  
Dennis Zerby ◽  
Michael Carey ◽  
Paul M. Lieberman
Keyword(s):  
Transcription Factor ◽  
Dna Binding ◽  
Binding Protein ◽  
Tata Binding Protein ◽  
Associated Factor

scholarly journals TFIIA Interacts with TFIID via Association with TATA-Binding Protein and TAF40

2001 ◽  
Vol 21 (5) ◽  
pp. 1737-1746 ◽  
Author(s):  
Susan M. Kraemer ◽  
Ryan T. Ranallo ◽  
Ryan C. Ogg ◽  
Laurie A. Stargell
Keyword(s):  
Transcription Factor ◽  
Rna Polymerase Ii ◽  
Functional Role ◽  
Associated Factors ◽  
Binding Protein ◽  
Tata Binding Protein ◽  
Functional Interaction ◽  
General Transcription Factor ◽  
Tata Element

ABSTRACT TFIIA and TATA-binding protein (TBP) associate directly at the TATA element of genes transcribed by RNA polymerase II. In vivo, TBP is complexed with approximately 14 TBP-associated factors (TAFs) to form the general transcription factor TFIID. How TFIIA and TFIID communicate is not well understood. We show that in addition to making direct contacts with TBP, yeast TAF40 interacts directly and specifically with TFIIA. Mutational analyses of the Toa2 subunit of TFIIA indicate that loss of functional interaction between TFIIA and TAF40 results in conditional growth phenotypes and defects in transcription. These results demonstrate that the TFIIA-TAF40 interaction is important in vivo and indicate a functional role for TAF40 as a bridging factor between TFIIA and TFIID.

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