scholarly journals Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line. Effect of lysosomotropic agents.

1983 ◽  
Vol 258 (16) ◽  
pp. 9681-9689 ◽  
Author(s):  
A Ciechanover ◽  
A L Schwartz ◽  
A Dautry-Varsat ◽  
H F Lodish
Keyword(s):  
Cell Line ◽  
Transferrin Receptor ◽  
Hepatoma Cell ◽  
Hepatoma Cell Line ◽  
Human Hepatoma ◽  
Human Hepatoma Cell ◽  
Human Hepatoma Cell Line ◽  
Lysosomotropic Agents ◽  
Kinetics Of

scholarly journals Intracellular interactions of transferrin and its receptor during biosynthesis.

1990 ◽  
Vol 111 (4) ◽  
pp. 1383-1392 ◽  
Author(s):  
J J Neefjes ◽  
T Hengeveld ◽  
O Tol ◽  
H L Ploegh
Keyword(s):  
Cell Surface ◽  
Cell Line ◽  
Transferrin Receptor ◽  
Hepatoma Cell ◽  
Hepatoma Cell Line ◽  
Human Hepatoma ◽  
Human Hepatoma Cell ◽  
Human Hepatoma Cell Line ◽  
Hepatoma Cell Line Hepg2 ◽  
Acidic Compartment

The interactions between transferrin (Tf) and transferrin receptor (Tfr) as they occur during biosynthesis were studied in the human hepatoma cell line HepG2, which synthesizes both. Early during biosynthesis the Tfr monomer is converted to a disulfide-linked Tfr dimer. The Tfr monomer is not able to bind Tf, but Tf binding is observed as soon as the covalent Tfr dimer is formed and can take place in the ER. The Tf-Tfr complex is transported through the Golgi reticulum and trans-Golgi reticulum (TGR) and is ultimately delivered to an acidic compartment, where Tf releases its Fe3+. We did not observe conversion of Tf to apoTf in the TGR, showing that the part of the TGR passed by secreted Tf has a pH higher than 5.5. We conclude that when a ligand-receptor combination is synthesized by one and the same cell, ligand and receptor can interact during biosynthesis and be transported to the cell surface.

Bis(hydroxyphenyl)methane—bisphenol F—metabolism by the HepG2 human hepatoma cell line and cryopreserved human hepatocytes

2011 ◽  
Vol 34 (4) ◽  
pp. 445-453 ◽  
Author(s):  
Coralie Dumont ◽  
Elisabeth Perdu ◽  
Georges de Sousa ◽  
Laurent Debrauwer ◽  
Roger Rahmani ◽  
...  
Keyword(s):  
Cell Line ◽  
Hepatoma Cell ◽  
Human Hepatocytes ◽  
Hepatoma Cell Line ◽  
Human Hepatoma ◽  
Human Hepatoma Cell ◽  
Human Hepatoma Cell Line ◽  
Bisphenol F

Protective effect of Centaurea pallescens Del. against CCl4-induced injury on a human hepatoma cell line (Huh7)

2013 ◽  
Vol 22 (12) ◽  
pp. 5700-5706 ◽  
Author(s):  
Hossam M. Abdallah ◽  
Mona A. Mohamed ◽  
Allia M. Abdou ◽  
Manal M. Hamed ◽  
Ashraf B. Abdel-Naim ◽  
...  
Keyword(s):  
Protective Effect ◽  
Cell Line ◽  
Hepatoma Cell ◽  
Hepatoma Cell Line ◽  
Human Hepatoma ◽  
Human Hepatoma Cell ◽  
Human Hepatoma Cell Line
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