scholarly journals The amino terminus of ADP-ribosylation factor (ARF) 1 is essential for interaction with Gs and ARF GTPase-activating protein.

1994 ◽  
Vol 269 (47) ◽  
pp. 29490-29494 ◽  
Author(s):  
P A Randazzo ◽  
T Terui ◽  
S Sturch ◽  
R A Kahn
Keyword(s):  
Amino Terminus ◽  
Gtpase Activating Protein ◽  
Adp Ribosylation ◽  
Adp Ribosylation Factor

scholarly journals Involvement of a novel ADP-ribosylation factor GTPase-activating protein, SMAP, in membrane trafficking: Implications in cancer cell biology

2006 ◽  
Vol 97 (9) ◽  
pp. 801-806 ◽  
Author(s):  
Kenji Tanabe ◽  
Shunsuke Kon ◽  
Waka Natsume ◽  
Tetsuo Torii ◽  
Toshio Watanabe ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Membrane Trafficking ◽  
Cell Biology ◽  
Gtpase Activating Protein ◽  
Adp Ribosylation ◽  
Adp Ribosylation Factor

scholarly journals A Class I ADP-Ribosylation Factor GTPase-Activating Protein Is Critical for Maintaining Directional Root Hair Growth in Arabidopsis

2008 ◽  
Vol 147 (4) ◽  
pp. 1659-1674 ◽  
Author(s):  
Cheol-Min Yoo ◽  
Jiangqi Wen ◽  
Christy M. Motes ◽  
J. Alan Sparks ◽  
Elison B. Blancaflor
Keyword(s):  
Root Hair ◽  
Hair Growth ◽  
Class I ◽  
Gtpase Activating Protein ◽  
Adp Ribosylation ◽  
Root Hair Growth ◽  
Adp Ribosylation Factor

scholarly journals Adp Ribosylation Factor-like Protein 2 (Arl2) Regulates the Interaction of Tubulin-Folding Cofactor D with Native Tubulin

2000 ◽  
Vol 149 (5) ◽  
pp. 1087-1096 ◽  
Author(s):  
Arunashree Bhamidipati ◽  
Sally A. Lewis ◽  
Nicholas J. Cowan
Keyword(s):  
Cultured Cells ◽  
Gtpase Activating Protein ◽  
Adp Ribosylation ◽  
Chaperone Protein ◽  
Ras Family ◽  
Mutant Forms ◽  
Adp Ribosylation Factor ◽  
Β Tubulin

The ADP ribosylation factor-like proteins (Arls) are a family of small monomeric G proteins of unknown function. Here, we show that Arl2 interacts with the tubulin-specific chaperone protein known as cofactor D. Cofactors C, D, and E assemble the α/β- tubulin heterodimer and also interact with native tubulin, stimulating it to hydrolyze GTP and thus acting together as a β-tubulin GTPase activating protein (GAP). We find that Arl2 downregulates the tubulin GAP activity of C, D, and E, and inhibits the binding of D to native tubulin in vitro. We also find that overexpression of cofactors D or E in cultured cells results in the destruction of the tubulin heterodimer and of microtubules. Arl2 specifically prevents destruction of tubulin and microtubules by cofactor D, but not by cofactor E. We generated mutant forms of Arl2 based on the known properties of classical Ras-family mutations. Experiments using these altered forms of Arl2 in vitro and in vivo demonstrate that it is GDP-bound Arl2 that interacts with cofactor D, thereby averting tubulin and microtubule destruction. These data establish a role for Arl2 in modulating the interaction of tubulin-folding cofactors with native tubulin in vivo.

scholarly journals ADP-ribosylation Factor-directed GTPase-activating Protein

1995 ◽  
Vol 270 (10) ◽  
pp. 5232-5237 ◽  
Author(s):  
Vardit Makler ◽  
Edna Cukierman ◽  
Miriam Rotman ◽  
Arie Admon ◽  
Dan Cassel
Keyword(s):  
Gtpase Activating Protein ◽  
Adp Ribosylation ◽  
Adp Ribosylation Factor

scholarly journals ADP-Ribosylation Factor 6 Regulates Glioma Cell Invasion through the IQ-Domain GTPase-Activating Protein 1-Rac1–Mediated Pathway

2009 ◽  
Vol 69 (3) ◽  
pp. 794-801 ◽  
Author(s):  
Bo Hu ◽  
Binhai Shi ◽  
Michael J. Jarzynka ◽  
Jia-Jean Yiin ◽  
Crislyn D'Souza-Schorey ◽  
...  
Keyword(s):  
Cell Invasion ◽  
Glioma Cell ◽  
Gtpase Activating Protein ◽  
Adp Ribosylation ◽  
Adp Ribosylation Factor

scholarly journals Characterization of a GTPase-activating Protein That Stimulates GTP Hydrolysis by Both ADP-ribosylation Factor (ARF) and ARF-like Proteins

1996 ◽  
Vol 271 (39) ◽  
pp. 24005-24009 ◽  
Author(s):  
Min Ding ◽  
Nicolas Vitale ◽  
Su-Chen Tsai ◽  
Ronald Adamik ◽  
Joel Moss ◽  
...  
Keyword(s):  
Gtpase Activating Protein ◽  
Gtp Hydrolysis ◽  
Adp Ribosylation ◽  
Adp Ribosylation Factor

scholarly journals Role of Coatomer and Phospholipids in GTPase-activating Protein-dependent Hydrolysis of GTP by ADP-ribosylation Factor-1

2000 ◽  
Vol 275 (31) ◽  
pp. 23615-23619 ◽  
Author(s):  
Edith Szafer ◽  
Elah Pick ◽  
Miriam Rotman ◽  
Sagie Zuck ◽  
Irit Huber ◽  
...  
Keyword(s):  
Gtpase Activating Protein ◽  
Adp Ribosylation ◽  
Hydrolysis Of ◽  
Adp Ribosylation Factor
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