Synthesis, phosphorylation, and degradation of multiple forms of the platelet-derived growth factor receptor studied using a monoclonal antibody.

C E Hart; R A Seifert; R Ross; D F Bowen-Pope

doi:10.1016/s0021-9258(18)61031-2

Synthesis, phosphorylation, and degradation of multiple forms of the platelet-derived growth factor receptor studied using a monoclonal antibody.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)61031-2 ◽

1987 ◽

Vol 262 (22) ◽

pp. 10780-10785 ◽

Cited By ~ 8

Author(s):

C E Hart ◽

R A Seifert ◽

R Ross ◽

D F Bowen-Pope

Keyword(s):

Monoclonal Antibody ◽

Growth Factor ◽

Growth Factor Receptor ◽

Platelet Derived Growth Factor ◽

Multiple Forms

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A Novel Pharmacodynamic Biomarker and Mechanistic Modeling Facilitate the Development of Tovetumab, a Monoclonal Antibody Directed Against Platelet-Derived Growth Factor Receptor Alpha, for Cancer Therapy

The AAPS Journal ◽

10.1208/s12248-020-00523-3 ◽

2020 ◽

Vol 23 (1) ◽

Author(s):

Meina Liang ◽

Bing Wang ◽

Amy Schneider ◽

Inna Vainshtein ◽

Lorin Roskos

Keyword(s):

Monoclonal Antibody ◽

Growth Factor ◽

Cancer Therapy ◽

Growth Factor Receptor ◽

Mechanistic Modeling ◽

Platelet Derived Growth Factor ◽

Receptor Alpha ◽

Factor Receptor Alpha

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Targeting the platelet-derived growth factor receptor α with a neutralizing human monoclonal antibody inhibits the growth of tumor xenografts: Implications as a potential therapeutic target

Molecular Cancer Therapeutics ◽

10.1158/1535-7163.mct-04-0114 ◽

2005 ◽

Vol 4 (3) ◽

pp. 369-379 ◽

Cited By ~ 2

Author(s):

Nick Loizos ◽

Yan Xu ◽

Jim Huber ◽

Meilin Liu ◽

Dan Lu ◽

...

Keyword(s):

Monoclonal Antibody ◽

Growth Factor ◽

Therapeutic Target ◽

Human Monoclonal Antibody ◽

Growth Factor Receptor ◽

Platelet Derived Growth Factor ◽

Potential Therapeutic Target ◽

Tumor Xenografts ◽

Growth Of Tumor

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Evidence for the platelet-derived growth factor-stimulated tyrosine phosphorylation of the platelet-derived growth factor receptor in vivo. Immunopurification using a monoclonal antibody to phosphotyrosine.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)42879-1 ◽

1984 ◽

Vol 259 (12) ◽

pp. 7909-7915 ◽

Cited By ~ 29

Author(s):

A R Frackelton ◽

P M Tremble ◽

L T Williams

Keyword(s):

Monoclonal Antibody ◽

Growth Factor ◽

Tyrosine Phosphorylation ◽

Growth Factor Receptor ◽

Platelet Derived Growth Factor

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A phase I study of olaratumab, an anti-platelet-derived growth factor receptor alpha (PDGFRα) monoclonal antibody, in patients with advanced solid tumors

Cancer Chemotherapy and Pharmacology ◽

10.1007/s00280-014-2389-9 ◽

2014 ◽

Vol 73 (3) ◽

pp. 595-604 ◽

Cited By ~ 42

Author(s):

E. Gabriela Chiorean ◽

Christopher Sweeney ◽

Hagop Youssoufian ◽

Amy Qin ◽

Aruna Dontabhaktuni ◽

...

Keyword(s):

Monoclonal Antibody ◽

Growth Factor ◽

Phase I ◽

Solid Tumors ◽

Phase I Study ◽

Growth Factor Receptor ◽

Platelet Derived Growth Factor ◽

Advanced Solid Tumors ◽

Receptor Alpha ◽

Factor Receptor Alpha

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Rationale for the development of IMC-3G3, a fully human immunoglobulin G subclass 1 monoclonal antibody targeting the platelet-derived growth factor receptor α

Cancer ◽

10.1002/cncr.24788 ◽

2010 ◽

Vol 116 (S4) ◽

pp. 1018-1026 ◽

Cited By ~ 39

Author(s):

Gaurav D. Shah ◽

Nick Loizos ◽

Hagop Youssoufian ◽

Jonathan D. Schwartz ◽

Eric K. Rowinsky

Keyword(s):

Monoclonal Antibody ◽

Growth Factor ◽

Immunoglobulin G ◽

Growth Factor Receptor ◽

Human Immunoglobulin ◽

Platelet Derived Growth Factor ◽

Human Immunoglobulin G ◽

Antibody Targeting ◽

Immunoglobulin G Subclass

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263: Expression of Epidermal Growth Factor Receptor and Platelet-Derived Growth Factor Receptor in Prostate Cancer

The Journal of Urology ◽

10.1016/s0022-5347(18)32530-8 ◽

2006 ◽

Vol 175 (4S) ◽

pp. 87-88

Author(s):

Chang Wook Jeong ◽

Cheol Kwak ◽

Gheeyoung Choe ◽

Sang Eun Lee

Keyword(s):

Prostate Cancer ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Platelet Derived Growth Factor ◽

Epidermal Growth

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IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody for treatment of head and neck cancer

Seminars in Oncology ◽

10.1053/sonc.2002.35644 ◽

2002 ◽

Vol 29 (5 Suppl 14) ◽

pp. 18-30 ◽

Cited By ~ 58

Author(s):

Roy S. Herbst ◽

Waun Ki Hong

Keyword(s):

Monoclonal Antibody ◽

Epidermal Growth Factor Receptor ◽

Head And Neck Cancer ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Head And Neck ◽

Neck Cancer ◽

Growth Factor Receptor ◽

Epidermal Growth ◽

Receptor Monoclonal Antibody

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Platelet-Derived Growth Factor Receptor-Like Protein

10.32388/zebu6x ◽

2020 ◽

Author(s):

Keyword(s):

Growth Factor ◽

Growth Factor Receptor ◽

Platelet Derived Growth Factor

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Faculty Opinions recommendation of Sunitinib inhibits the phosphorylation of platelet-derived growth factor receptor β in the skin of mice with scleroderma-like features and prevents the development of the disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13477009.14857115 ◽

2012 ◽

Author(s):

Darryl Knight

Keyword(s):

Growth Factor ◽

Growth Factor Receptor ◽

Platelet Derived Growth Factor

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Genetic Polymorphism on the Pharmacokinetics and Pharmacodynamics of Platelet-derived Growth Factor Receptor (PDGFR) Kinase Inhibitors

Current Drug Metabolism ◽

10.2174/1389200219666180629112943 ◽

2018 ◽

Vol 19 (14) ◽

pp. 1168-1181 ◽

Cited By ~ 2

Author(s):

Yi Qian ◽

Lei Yu ◽

Xue-Hui Zhang ◽

Zi-Qing-Yun Yuan ◽

Ping Zhao ◽

...

Keyword(s):

Genetic Polymorphism ◽

Growth Factor ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Platelet Derived Growth Factor ◽

Pharmacokinetics And Pharmacodynamics

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