scholarly journals Role of Folic Acid and Energy Intake in Nucleic Acid Synthesis

1959 ◽  
Vol 234 (3) ◽  
pp. 625-627
Author(s):  
Ranjan Mehta ◽  
David A. Vaughan ◽  
Shreepad R. Wagle ◽  
Kendall D. Barbee ◽  
S.P. Mistry ◽  
...  
Keyword(s):  
Folic Acid ◽  
Nucleic Acid ◽  
Energy Intake ◽  
Acid Synthesis ◽  
Nucleic Acid Synthesis

Inhibition of nucleic acid synthesis caused by X-irradiation of the nucleolus

1960 ◽  
Vol 152 (948) ◽  
pp. 387-396 ◽  
Keyword(s):  
Nucleic Acid ◽  
Ultra Violet ◽  
Acid Synthesis ◽  
Nucleic Acid Synthesis ◽  
Effective Diameter ◽  
X Rays ◽  
Narrow Beam ◽  
Equal Dose ◽  
X Irradiation

Living cells grown in tissue culture have been irradiated with a narrow beam of soft X-rays of effective diameter 2·5 μ. The method has been used in conjunction with quantitative ultra-violet photomicrography to investigate the role of the nucleolus in nucleic acid synthesis. The results show that X-irradiation of the nucleolus reduces the amount of nucleic acid synthesized in the nucleus when measured 3 to 7 h after irradiation, whereas X-irradiation of the nuclear sap with an equal dose does not show this effect. The significance of this is discussed.

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