scholarly journals THE EFFECT OF HIGH PROTEIN DIETS ON THE KIDNEYS OF RATS

1926 ◽  
Vol 67 (1) ◽  
pp. 101-107
Author(s):  
Henry Jackson ◽  
Margaret D. Riggs
Keyword(s):  
High Protein ◽  
High Protein Diets ◽  
Protein Diets

Dietary protein paradox: decrease of amino acid availability induced by high-protein diets

1993 ◽  
Vol 264 (6) ◽  
pp. G1057-G1065 ◽  
Author(s):  
C. Moundras ◽  
C. Remesy ◽  
C. Demigne
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Dietary Protein ◽  
High Protein ◽  
Glutamine Metabolism ◽  
Metabolic Adaptation ◽  
Casein Diet ◽  
Serine Dehydratase ◽  
High Protein Diets ◽  
Protein Diets

The aim of the present study was to evaluate the effect of changes in dietary protein level on overall availability of amino acids for tissues. For this purpose, rats were adapted to diets containing various concentrations of casein (7.5, 15, 30, and 60%) and were sampled either during the postprandial or postabsorptive period. In rats fed the protein-deficient diet, glucogenic amino acids (except threonine) tended to accumulate in plasma, liver, and muscles. In rats fed high-protein diets, the hepatic balance of glucogenic amino acids was markedly enhanced and their liver concentrations were consistently depressed. This response was the result of a marked induction of amino acid catabolism (a 45-fold increase of liver threonine-serine dehydratase activity was observed with the 60% casein diet). The muscle concentrations of threonine, serine, and glycine underwent changes parallel to plasma and liver concentrations, and a significant reduction of glutamine was observed. During the postabsorptive period, adaptation to high-protein diets resulted in a sustained catabolism of most glucogenic amino acids, which accentuated the drop in their concentrations (especially threonine) in all the compartments studied. The time course of metabolic adaptation from a 60 to a 15% casein diet has also been investigated. Adaptation of alanine and glutamine metabolism was rapid, whereas that of threonine, serine, and glycine was delayed and required 7-11 days. This was paralleled by a relatively slow decay of liver threonine-serine dehydratase (T-SDH) activity in contrast to the rapid adaptation of pyruvate kinase activity after refeeding a high-carbohydrate diet.(ABSTRACT TRUNCATED AT 250 WORDS)

Use of low carbohydrate, high protein diets in cats with diabetes mellitus

2008 ◽  
Vol 92 (2) ◽  
pp. 219-220 ◽  
Author(s):  
T. C. Hall ◽  
O. M. Mahony ◽  
L. M. Freeman ◽  
E. A. Rozanski
Keyword(s):  
Diabetes Mellitus ◽  
High Protein ◽  
Low Carbohydrate ◽  
High Protein Diets ◽  
Protein Diets

scholarly journals The protein source determines the potential of high protein diets to attenuate obesity development in C57BL/6J mice

Adipocyte ◽  
2016 ◽  
Vol 5 (2) ◽  
pp. 196-211 ◽  
Author(s):  
Ulrike Liisberg ◽  
Lene Secher Myrmel ◽  
Even Fjære ◽  
Alexander K. Rønnevik ◽  
Susanne Bjelland ◽  
...  
Keyword(s):  
High Protein ◽  
Protein Source ◽  
High Protein Diets ◽  
Protein Diets

Decreased Warfarin Effect after Initiation of High-Protein, Low-Carbohydrate Diets

2005 ◽  
Vol 39 (4) ◽  
pp. 744-747 ◽  
Author(s):  
Stuart J Beatty ◽  
Bella H Mehta ◽  
Jennifer L Rodis
Keyword(s):  
Serum Albumin ◽  
Warfarin Therapy ◽  
Anticoagulation Therapy ◽  
Warfarin Dose ◽  
High Protein ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate ◽  
High Protein Diets ◽  
Protein Diets

OBJECTIVE: To report 2 cases of decreased international normalized ratio (INR) after initiation of a high-protein, low-carbohydrate diet. CASE SUMMARIES: Case 1. A 67-year-old white woman had been receiving warfarin for 3 years for venous thromboembolism. After initiation of a high-protein, low-carbohydrate diet, the patient required a 22.2% increase (from 45 to 57.5 mg/wk) in warfarin dose. Her INR remained in the therapeutic range on this dose for 8 weeks. When the patient stopped the high-protein, low-carbohydrate diet, a decrease back to the original warfarin dose was required to return to a therapeutic INR. Case 2. A 58-year-old white man had been receiving warfarin for 8 years for a cerebrovascular accident. Initiation of a high-protein, low-carbohydrate diet resulted in a 30% increase (from 26.25 to 37.5 mg/wk) in warfarin dose. His warfarin dose was reduced to the original dose after he stopped the high-protein, low-carbohydrate diet. DISCUSSION: The Naranjo probability scale indicated a possible adverse effect between warfarin and high-protein diets. High-protein diets have been shown to increase serum albumin levels. This may result in more warfarin binding to serum albumin, thereby decreasing the anticoagulant effect of warfarin. The increase of albumin occurs rapidly after initiation of a high-protein diet and appears to promptly affect anticoagulation therapy with warfarin. CONCLUSIONS: These cases indicate a significant interaction between high-protein, low-carbohydrate diets and warfarin therapy. Patients receiving warfarin therapy should be educated on and monitored for the potential interaction that occurs with warfarin therapy and high-protein, low-carbohydrate diets.

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