scholarly journals RELATIONSHIP BETWEEN CHOLESTEROL AND CHOLESTEROL ESTERS IN THE BLOOD DURING FAT ABSORPTION

1917 ◽  
Vol 32 (3) ◽  
pp. 337-346
Author(s):  
Arthur Knudson
Author(s):  
Dean A. Handley ◽  
Cynthia M. Arbeeny ◽  
Larry D. Witte

Low density lipoproteins (LDL) are the major cholesterol carrying particles in the blood. Using cultured cells, it has been shown that LDL particles interact with specific surface receptors and are internalized via a coated pit-coated vesicle pathway for lysosomal catabolism. This (Pathway has been visualized using LDL labeled to ferritin or colloidal gold. It is now recognized that certain lysomotropic agents, such as chloroquine, inhibit lysosomal enzymes that degrade protein and cholesterol esters. By interrupting cholesterol ester hydrolysis, chloroquine treatment results in lysosomal accumulation of cholesterol esters from internalized LDL. Using LDL conjugated to colloidal gold, we have examined the ultrastructural effects of chloroquine on lipoprotein uptake by normal cultured fibroblasts.


1952 ◽  
Vol 20 (2) ◽  
pp. 287-293 ◽  
Author(s):  
F.S. Brien ◽  
D.A. Turner ◽  
E.M. Watson ◽  
J.H. Geddes
Keyword(s):  

Diabetes ◽  
1994 ◽  
Vol 43 (11) ◽  
pp. 1353-1357 ◽  
Author(s):  
B. Vessby ◽  
A. Aro ◽  
E. Skarfors ◽  
L. Berglund ◽  
I. Salminen ◽  
...  

1964 ◽  
Vol 5 (4) ◽  
pp. 578-586 ◽  
Author(s):  
DeWitt S. Goodman ◽  
Tatsuji Shiratori
Keyword(s):  

1912 ◽  
Vol 11 (4) ◽  
pp. 429-434
Author(s):  
W.R. Bloor
Keyword(s):  

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