scholarly journals Structure-activity relationship study of human interleukin-3. Identification of residues required for biological activity by site-directed mutagenesis

1991 ◽  
Vol 266 (16) ◽  
pp. 10624-10631
Author(s):  
N.A. Lokker ◽  
N.R. Movva ◽  
U. Strittmatter ◽  
B. Fagg ◽  
G. Zenke
Keyword(s):  
Biological Activity ◽  
Structure Activity Relationship ◽  
Site Directed Mutagenesis ◽  
Activity Relationship ◽  
Directed Mutagenesis ◽  
Interleukin 3 ◽  
Structure Activity ◽  
Relationship Study

scholarly journals Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents

Molecules ◽  
2019 ◽  
Vol 24 (19) ◽  
pp. 3433 ◽  
Author(s):  
Anastasia Khandazhinskaya ◽  
Elena Matyugina ◽  
Pavel Solyev ◽  
Maggie Wilkinson ◽  
Karen Buckheit ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Biological Activity ◽  
Antibacterial Agents ◽  
Structure Activity Relationship ◽  
Nucleoside Analogues ◽  
Activity Relationship ◽  
Carbocyclic Nucleosides ◽  
Structure Activity ◽  
Small Structure ◽  
Relationship Study

Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both Mycobacterium tuberculosis and several parasitic strains. As a result, a small structure activity relationship study was designed to further probe their activity and potential. Their synthesis and the results of the subsequent biological activity are reported herein.

Structure–activity relationship study of synthetic hydrazines as ecdysone agonists in the control of spruce budworm (Choristoneurafumiferana)

1995 ◽  
Vol 73 (4) ◽  
pp. 550-557 ◽  
Author(s):  
Anmar K. Mohammed-Ali ◽  
Tak-Hang Chan ◽  
Anthony W. Thomas ◽  
George M. Strunz ◽  
Brent Jewett
Keyword(s):  
Biological Activity ◽  
Spruce Budworm ◽  
Quantitative Structure Activity Relationship ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Quantitative Structure ◽  
Molecular Mechanics Calculations ◽  
Structure Activity ◽  
Relationship Study ◽  
Ecdysone Agonist

A quantitative structure–activity relationship study was performed for a number of aroylhydrazine compounds with respect to their biological activity against spruce budworm. It was found that the biological activity can be modulated by substituents on the aromatic rings. Substituents with high π value and small L value lead to increase in biological activity. Molecular mechanics calculations were used to explain how the active compounds may mimic the strong-binding Y region of ecdysone. Keywords: spruce budworm, ecdysone, agonist, hydrazines, quantitative structure–activity relationship.

Probing the structure-activity relationship of Escherichia coli LT-A by site-directed mutagenesis

1994 ◽  
Vol 14 (1) ◽  
pp. 51-60 ◽  
Author(s):  
Mariagrazia Pizza ◽  
Mario Domenighini ◽  
Wim Hol ◽  
Valentine Giannelli ◽  
Maria Rita Fontana ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Structure Activity Relationship ◽  
Site Directed Mutagenesis ◽  
Activity Relationship ◽  
Directed Mutagenesis ◽  
Structure Activity ◽  
Relationship Of
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