Isolation and characterization of three new polymyxins in polymyxins B and E by high-performance liquid chromatography

1981 ◽  
Vol 218 ◽  
pp. 653-661 ◽  
Author(s):  
Ingelise Elverdam ◽  
Per Larsen ◽  
Erik Lund
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Isolation And Characterization

scholarly journals Synthesis, Isolation and Characterization of Process-Related Impurities in Oseltamivir Phosphate

2012 ◽  
Vol 9 (1) ◽  
pp. 113-120 ◽  
Author(s):  
Yogesh Kumar Sharma ◽  
Dau Dayal Agarwal ◽  
Sudesh Bhure ◽  
Sanjay Singh Rathore ◽  
Chakravir Rawat ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Mass Number ◽  
Reverse Phase ◽  
Related Impurities ◽  
Isolation And Characterization ◽  
Bulk Drug ◽  
Oseltamivir Phosphate

Three known impurities in oseltamivir phosphate bulk drug at level 0.1% (ranging from 0.05-0.1%) were detected by gradient reverse phase high performance liquid chromatography. These impurities were preliminarily identified by the mass number of the impurities. Different experiments were conducted and finally the known impurities were synthesized and characterized.

scholarly journals Efficient resolution of racemic crown-shaped cyclotriveratrylene derivatives and isolation and characterization of the intermediate saddle isomer

2019 ◽  
Vol 15 ◽  
pp. 1339-1346
Author(s):  
Sven Götz ◽  
Andreas Schneider ◽  
Arne Lützen
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Nmr Spectroscopy ◽  
High Performance ◽  
Chiral Stationary Phase ◽  
Hplc Separation ◽  
Promising Alternative ◽  
Isolation And Characterization ◽  
C Nmr

The preparative resolution of a trifunctionalized C 3-symmetrical chiral cyclotriveratrylene derivative was achieved via high-performance liquid chromatography (HPLC) on a chiral stationary phase. This approach is a promising alternative to the previously reported resolution through formation of diastereomeric esters because it involves fewer synthetic steps and is less prone to thermal (re)racemization. During these studies an intermediate saddle conformer could also be isolated and characterized by 1H and 13C NMR spectroscopy. The HPLC separation method was further developed in order to allow investigations on the racemization behavior of the cyclotriveratrylene derivative.

scholarly journals Isolation and Characterization of a Chemical from Tomato Apices that Stimulates Plant Growth

HortScience ◽  
1990 ◽  
Vol 25 (7) ◽  
pp. 769-771
Author(s):  
Yichun Wang ◽  
Violet Wert ◽  
Muraleedharan Nair ◽  
Stanley Ries
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Zea Mays ◽  
High Performance Liquid Chromatography ◽  
Oryza Sativa ◽  
Liquid Chromatography ◽  
High Performance ◽  
Water Extract ◽  
Isolation And Characterization ◽  
Layer Chromatography

A methanol: water extract of tomato (Lycopersion esculentum Mill.) apices increased the growth of the alga Chlamydomonas reinhardtii. The active substance from the dried shoot apices was purified by C18 flash column and high performance liquid chromatography. The purified extract enhanced the growth of tomato, corn (Zea mays L.), and rice (Oryza sativa L.) seedlings at concentrations less than 1.0 mg·liter-1. With Chlamydomonas, the purified extract increased cell division 111% at 0.1 mg·liter-1 and chlorophyll content 23% at 10 mg·liter-1 in 18 hours. Nuclear magnetic resonance and mass spectroscopy indicated that the purified fraction was a mixture of compounds having sugar moieties. Analysis by thin layer chromatography showed that the fraction was ninhydrin positive and more polar than the known plant hormones studied.

scholarly journals Synthesis, Isolation and Characterization of Process-Related Impurities in Salbutamol Sulphate

2011 ◽  
Vol 8 (4) ◽  
pp. 1720-1727 ◽  
Author(s):  
Yogesh Kumar Sharma ◽  
Dau Dayal Agarwal ◽  
Sudesh Bhure ◽  
Rajendra Nath Mukharjee ◽  
Pramod Kumar Sahu ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Mass Number ◽  
Reverse Phase ◽  
Salbutamol Sulphate ◽  
Related Impurities ◽  
Isolation And Characterization ◽  
Bulk Drug

Three known and one unknown impurities in salbutamol sulphate bulk drug at level 0.1% (ranging from 0.05-0.1%) were detected by gradient reverse phase high performance liquid chromatography. These impurities were preliminarily identified by the mass number of the impurities. Different experiments were conducted and finally synthesized and characterized the known and unknown imputities.

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