Non-linear calibration functions in ion chromatography with suppressed conductivity detection using hydroxide eluents

2002 ◽  
Vol 957 (2) ◽  
pp. 99-109 ◽  
Author(s):  
Thomas Brinkmann ◽  
Christian H. Specht ◽  
Fritz H. Frimmel
Keyword(s):  
Ion Chromatography ◽  
Linear Calibration ◽  
Conductivity Detection ◽  
Non Linear ◽  
Suppressed Conductivity Detection

New membrane-based electrolytic suppressor device for suppressed conductivity detection in ion chromatography

1993 ◽  
Vol 640 (1-2) ◽  
pp. 97-109 ◽  
Author(s):  
Steve Rabin ◽  
John Stillian ◽  
Victor Barreto ◽  
Keith Friedman ◽  
Mahmood Toofan
Keyword(s):  
Ion Chromatography ◽  
Conductivity Detection ◽  
Suppressed Conductivity Detection

scholarly journals A risk-based approach to validation of ion chromatography methods using suppressed conductivity

AAPS Open ◽  
2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Deanna J. Nelson ◽  
G. Dean Marbury
Keyword(s):  
Analytical Chemistry ◽  
Method Validation ◽  
Ion Chromatography ◽  
Hplc Method ◽  
Conductivity Detection ◽  
Separation Techniques ◽  
Alternative Approach ◽  
Suppressed Conductivity Detection ◽  
Traditional Approaches ◽  
Development And Validation

AbstractIon chromatography (IC) has evolved into one of the most widely used separation techniques of analytical chemistry. Consequently, the number of users of this method is continuously growing. Analysts often assume that widely used guidelines for HPLC method validation in regulated environments routinely apply to IC. This manuscript provides an analysis of the potential shortcomings of traditional approaches to development and validation of IC methods using suppressed conductivity detection and a risk-based alternative approach to these activities. The goal of the alternative approach is a reduction in the risk of erroneous determinations of analytes when IC methods using suppressed conductivity detection are employed.

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