Natural history of optic pathway tumors in children with neurofibromatosis type 1: A longitudinal study

(1) Background. Scoliosis is the most common musculoskeletal manifestation of Neurofibromatosis type 1 (NF1), and it might be dystrophic (D) or non-dystrophic (ND) depending on the presence of dysplastic changes of the spine. The aim of our study was to describe the characteristics and natural history of patients with NF1 and scoliosis. (2) Methods. We retrospectively reviewed records from patients with NF1 and scoliosis. Scoliosis was classified as D if at least two dystrophic changes were documented at imaging. (3) Results. Of the 438 patients reviewed, 43 fulfilled inclusion criteria; 17 were classified in D group and 26 in ND. The groups did not differ in age and localization of scoliosis curvature. Surgery was needed more often in D group, but the between-group difference was not significant. Male-to-female ratios of 3:1 and 4:1 were reported in surgically treated NF1 patients with ND and D scoliosis, respectively. (4) Conclusions. Our data suggests independently by the presence of dysplastic changes affecting the spine that males with NF1 are more often affected by scoliosis that requires surgery.

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Fractional anisotropy of the optic radiations is associated with visual acuity loss in optic pathway gliomas of neurofibromatosis type 1

Neuro-Oncology ◽

10.1093/neuonc/not068 ◽

2013 ◽

Vol 15 (8) ◽

pp. 1088-1095 ◽

Cited By ~ 29

Author(s):

P. M. K. de Blank ◽

J. I. Berman ◽

G. T. Liu ◽

T. P. L. Roberts ◽

M. J. Fisher

Keyword(s):

Visual Acuity ◽

Fractional Anisotropy ◽

Neurofibromatosis Type 1 ◽

Neurofibromatosis Type ◽

Optic Pathway ◽

Visual Acuity Loss ◽

Optic Radiations ◽

Optic Pathway Gliomas

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Optic pathway glioma with intraocular extension in a child with neurofibromatosis type-1

Journal Français d Ophtalmologie ◽

10.1016/j.jfo.2019.09.016 ◽

2020 ◽

Vol 43 (5) ◽

pp. e179-e181

Author(s):

F. Palma-Carvajal ◽

H. González-Valdivia ◽

J.P. Figueroa-Vercellino ◽

C. Saavedra-Gutiérrez ◽

C. Rovira-Zurriaga ◽

...

Keyword(s):

Neurofibromatosis Type 1 ◽

Neurofibromatosis Type ◽

Optic Pathway Glioma ◽

Optic Pathway

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Follow-Up of Optic Pathway Gliomas in Children with Neurofibromatosis Type 1

Neuropediatrics ◽

10.1055/s-2008-1073043 ◽

1994 ◽

Vol 25 (06) ◽

pp. 295-300 ◽

Cited By ~ 34

Author(s):

Ch. Kuenzle ◽

M. Weissert ◽

E. Roulet ◽

H. Bode ◽

S. Schefer ◽

...

Keyword(s):

Neurofibromatosis Type 1 ◽

Neurofibromatosis Type ◽

Optic Pathway ◽

Optic Pathway Gliomas

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High-Dose Intravenous Vitamin C Treatment of a Child with Neurofibromatosis Type 1 and Optic Pathway Glioma: A Case Report

American Journal of Case Reports ◽

10.12659/ajcr.899754 ◽

2016 ◽

Vol 17 ◽

pp. 774-781 ◽

Cited By ~ 3

Author(s):

Nina Mikirova ◽

Ronald Hunnunghake ◽

Ruth C. Scimeca ◽

Charles Chinshaw ◽

Faryal Ali ◽

...

Keyword(s):

Case Report ◽

Vitamin C ◽

Neurofibromatosis Type 1 ◽

Neurofibromatosis Type ◽

Optic Pathway Glioma ◽

High Dose ◽

Optic Pathway ◽

Intravenous Vitamin

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Macrocephaly Is Not a Predictor of Optic Pathway Glioma Development or Treatment in Neurofibromatosis Type 1

Journal of Child Neurology ◽

10.1177/0883073816664659 ◽

2016 ◽

Vol 31 (14) ◽

pp. 1540-1545 ◽

Cited By ~ 3

Author(s):

Stephanie M. Morris ◽

Courtney L. Monroe ◽

David H. Gutmann

Keyword(s):

Prognostic Factor ◽

Brain Tumors ◽

Clinical Features ◽

Neurofibromatosis Type 1 ◽

Neurofibromatosis Type ◽

Optic Pathway Glioma ◽

Optic Pathway ◽

Clinical Progression ◽

Clinical Biomarkers

Neurofibromatosis type 1 is a common neurogenetic disorder characterized by significant clinical variability. As such, numerous studies have focused on identifying clinical, radiographic, or molecular biomarkers that predict the occurrence or progression of specific clinical features in individuals with neurofibromatosis type 1. One of these clinical biomarkers, macrocephaly, has been proposed as a prognostic factor for optic pathway glioma development. In the current study, the authors demonstrate that macrocephaly is not associated with the development of these brain tumors or the need to institute treatment for clinical progression. These findings suggest that macrocephaly is not a robust biomarker of optic pathway glioma formation or progression in children with neurofibromatosis type 1.

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