IN VIVO TRACKING AND LOCALIZATION OF ADIPOSE STEM CELLS IN AN ANIMAL MODEL OF STRESS URINARY INCONTINENCE (SUI): INTRAVASCULAR ADMINISTERED CELLS DO NOT HOME TO SITE OF INJURY

2008 ◽  
Vol 179 (4S) ◽  
pp. 473-473
Author(s):  
Valerie A Arboleda ◽  
Vanda D Lopez ◽  
Rong Zhang ◽  
Joanne Leung ◽  
Larissa V Rodriguez
Keyword(s):  
Stem Cells ◽  
Animal Model ◽  
Urinary Incontinence ◽  
Stress Urinary Incontinence ◽  
Adipose Stem Cells

scholarly journals Regenerative potential of human dental pulp stem cells in the treatment of stress urinary incontinence: In vitro and in vivo study

2019 ◽  
Vol 52 (6) ◽  
Author(s):  
Alessio Zordani ◽  
Alessandra Pisciotta ◽  
Laura Bertoni ◽  
Giulia Bertani ◽  
Antonio Vallarola ◽  
...  
Keyword(s):  
Stem Cells ◽  
Urinary Incontinence ◽  
Stress Urinary Incontinence ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
In Vivo Study ◽  
Human Dental Pulp

scholarly journals Autologous Adipose Stem Cells in Treatment of Female Stress Urinary Incontinence: Results of a Pilot Study

2014 ◽  
Vol 3 (8) ◽  
pp. 936-941 ◽  
Author(s):  
Kirsi Kuismanen ◽  
Reetta Sartoneva ◽  
Suvi Haimi ◽  
Bettina Mannerström ◽  
Eija Tomás ◽  
...  
Keyword(s):  
Stem Cells ◽  
Urinary Incontinence ◽  
Pilot Study ◽  
Stress Urinary Incontinence ◽  
Adipose Stem Cells ◽  
Female Stress Urinary Incontinence

scholarly journals Stem Cells from a Female Rat Model of Type 2 Diabetes/Obesity and Stress Urinary Incontinence Are Damaged by In Vitro Exposure to its Dyslipidemic Serum, Predicting Inadequate Repair Capacity In Vivo

2019 ◽  
Vol 20 (16) ◽  
pp. 4044 ◽  
Author(s):  
Istvan Kovanecz ◽  
Robert Gelfand ◽  
Guiting Lin ◽  
Sheila Sharifzad ◽  
Alec Ohanian ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Stem Cells ◽  
Urinary Incontinence ◽  
Stem Cell ◽  
Stress Urinary Incontinence ◽  
Rat Model ◽  
Repair Capacity

Female stress urinary incontinence (FSUI) is prevalent in women with type 2 diabetes/obesity (T2D/O), and treatment is not optimal. Autograph stem cell therapy surprisingly has poor efficacy. In the male rat model of T2D/O, it was demonstrated that epigenetic changes, triggered by long-term exposure to the dyslipidemic milieu, led to abnormal global transcriptional signatures (GTS) of genes and microRNAs (miR), and impaired the repair capacity of muscle-derived stem cells (MDSC). This was mimicked in vitro by treatment of MDSC with dyslipidemic serum or lipid factors. The current study aimed to predict whether these changes also occur in stem cells from female 12 weeks old T2D/O rats, a model of FSUI. MDSCs from T2D/O (ZF4-SC) and normal female rats (ZL4-SC) were treated in vitro with either dyslipidemic serum (ZFS) from late T2D/O 24 weeks old female Zucker fatty (ZF) rats, or normal serum (ZLS) from 24 weeks old female Zucker lean (ZL) rats, for 4 days and subjected to assays for fat deposition, apoptosis, scratch closing, myostatin, interleukin-6, and miR-GTS. The dyslipidemic ZFS affected both female stem cells more severely than in the male MDSC, with some gender-specific differences in miR-GTS. The changes in miR-GTS and myostatin/interleukin-6 balance may predict in vivo noxious effects of the T2D/O milieu that might impair autograft stem cell (SC) therapy for FSUI, but this requires future studies.

DOES TRANSPLANTATION OF ADIPOSE TISSUE-DERIVED STEM CELLS HAVE EFFECTS ON MICTURITION CENTER IN STRESS URINARY INCONTINENCE?: IN VIVO ANIMAL STUDY

2009 ◽  
Vol 181 (4S) ◽  
pp. 44-45 ◽  
Author(s):  
Khae Hawn Kim ◽  
Han Sae Lee ◽  
Tae Beom Kim ◽  
Sang Jin Yoon ◽  
Jung Chul Yun ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Urinary Incontinence ◽  
Stress Urinary Incontinence ◽  
Animal Study
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