Immunohistochemical and Enzyme Histochemical Localization of Peptidergic, Aminergic and Cholinergic Nerve Fibers in the Rat Seminal Vesicle

1990 ◽  
Vol 143 (1) ◽  
pp. 194-198 ◽  
Author(s):  
Kazunari Yuri
Keyword(s):  
Seminal Vesicle ◽  
Nerve Fibers ◽  
Histochemical Localization ◽  
Cholinergic Nerve ◽  
Rat Seminal Vesicle ◽  
Cholinergic Nerve Fibers

scholarly journals Identification of the origin of adrenergic and cholinergic nerve fibers within the superior hypogastric plexus of the human fetus

2013 ◽  
Vol 223 (1) ◽  
pp. 14-21 ◽  
Author(s):  
Mazen Zaitouna ◽  
Bayan Alsaid ◽  
Djibril Diallo ◽  
Gérard Benoit ◽  
Thomas Bessede
Keyword(s):  
Human Fetus ◽  
Nerve Fibers ◽  
Cholinergic Nerve ◽  
Hypogastric Plexus ◽  
Superior Hypogastric Plexus ◽  
Cholinergic Nerve Fibers

Aminergic and cholinergic innervations of the spinal cord blood vessels of cats

1983 ◽  
Vol 58 (6) ◽  
pp. 900-905 ◽  
Author(s):  
Toru Itakura
Keyword(s):  
Spinal Cord ◽  
Cord Blood ◽  
Blood Vessels ◽  
Nerve Fibers ◽  
Anterior Spinal Artery ◽  
Thoracic Spinal Cord ◽  
Cholinergic Nerve ◽  
Ischemic Change ◽  
Thoracic Spinal ◽  
Cholinergic Nerve Fibers

✓ The distribution patterns of aminergic and cholinergic nerve fibers in the feline spinal cord blood vessels were studied by means of amine histofluorescence and acetylcholinesterase (AChE) staining. These patterns were compared with those of the cerebral blood vessels. The anterior spinal artery had a dense network of aminergic and AChE-positive (probably cholinergic) nerve fibers. The posterior spinal vein, in contrast, exhibited only aminergic nerve fibers. Small intraparenchymal blood vessels in the spinal cord also had strongly fluorescent (probably peripheral) aminergic nerve fibers, as well as pial spinal blood vessels. This was a characteristic feature in the spinal cord. The distribution pattern and the density of these two sorts of nerve fibers in the anterior spinal artery varied widely with the individual segment of the spinal cord. The thoracic spinal cord had the lowest number of these nerve fibers of any part of the spinal cord. This fact may explain why the thoracic spinal cord is most susceptible to ischemic change.

scholarly journals Lack of mucosal cholinergic innervation is associated with increased risk of enterocolitis in Hirschsprung’s disease

2020 ◽  
Author(s):  
Simone Keck ◽  
Virginie Galati-Fournier ◽  
Urs Kym ◽  
Michèle Moesch ◽  
Jakob Usemann ◽  
...  
Keyword(s):  
Immune Cells ◽  
Hirschsprung's Disease ◽  
Hirschsprung’S Disease ◽  
Nerve Fibers ◽  
Cholinergic Innervation ◽  
Cholinergic Nerve ◽  
Link Type ◽  
Microbial Dysbiosis ◽  
The Impact ◽  
Cholinergic Nerve Fibers

Background & AimsHirschsprung’s disease (HSCR) is a congenital intestinal motility disorder defined by the absence of enteric nervous cells (ganglia). The development of HSCR-associated enterocolitis remains a life-threatening complication. Absence of enteric ganglia implicates extramural innervation of acetylcholine-secreting (cholinergic) nerve fibers. Cholinergic signals have been reported to control excessive inflammation, but the impact on HSCR-associated enterocolitis is unknown.MethodsWe enrolled 44 HSCR patients in a prospective multicenter study and grouped them according to their degree of colonic mucosal cholinergic innervation using immunohistochemistry. The fiber phenotype was correlated with the tissue cytokine profile as well as immune cell frequencies using quantitative reverse-transcribed real-time polymerase chain reaction (qRT-PCR) of whole colonic tissue and fluorescence-activated cell sorting (FACS) analysis of isolated colonic immune cells. Fiber-associated immune cells were identified using confocal immunofluorescence microscopy and characterized by RNA-seq analysis. Microbial dysbiosis was analyzed in colonic patient tissue using 16S rDNA gene sequencing. Finally, the fiber phenotype was correlated with postoperative enterocolitis manifestation.ResultsWe provided evidence that extrinsic mucosal innervation correlated with reduced interleukin (IL)-17 cytokine levels and T-helper-17 (Th17) cell frequencies. Bipolar CD14high macrophages colocalized with neurons and expressed significantly less interleukin-23, a Th17-promoting cytokine. HSCR patients lacking mucosal cholinergic nerve fibers showed microbial dysbiosis and had a higher incidence of postoperative enterocolitis.ConclusionThe mucosal fiber phenotype might serve as a new prognostic marker for enterocolitis development in HSCR patients and may offer an approach to personalized patient care and new future therapeutic options. (www.clinicaltrials.gov accessing number NCT03617640)

scholarly journals Distribution within the choroid of cholinergic nerve fibers from the ciliary ganglion in pigeons

1996 ◽  
Vol 36 (6) ◽  
pp. 775-786 ◽  
Author(s):  
Sherry Cuthbertson ◽  
Jennifer White ◽  
Malinda E.C. Fitzgerald ◽  
Yung-Feng Shih ◽  
Anton Reiner
Keyword(s):  
Nerve Fibers ◽  
Ciliary Ganglion ◽  
Cholinergic Nerve ◽  
Cholinergic Nerve Fibers
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