The hydroelastic response is significant from the viewpoint of the structural design of a Mega-Float. Equipping a Mega-Float with some additional structures, such as vertical plates, is one of the ways to reduce the hydroelastic response easily. However, in general, wave drift force acting on the Mega-Float may be increased, when the Mega-Float is equipped with the additional structures to reduce the response. In the present study, we developed a novel additional structure that was effective in the reduction of both hydroelastic response and wave drift force. Furthermore, we estimated the response of Mega-Float equipped with the additional structures, and compared the result with the value measured in at-sea experiments. As a result, we confirmed both the effectiveness of the novel additional structure and the validity of the estimation method.