Efficacy and Adverse Effects of Antiepileptic Drugs

1989 ◽  
Vol 36 (2) ◽  
pp. 435-448 ◽  
Author(s):  
John M. Pellock
Keyword(s):  
Adverse Effects ◽  
Antiepileptic Drugs

Overview of Lamotrigine and the New Antiepileptic Drugs: The Challenge

1997 ◽  
Vol 12 (1_suppl) ◽  
pp. S48-S52 ◽  
Author(s):  
John M. Pellock
Keyword(s):  
Adverse Effect ◽  
Adverse Effects ◽  
Antiepileptic Drugs ◽  
Adjunctive Therapy ◽  
Dose Titration ◽  
Childhood Epilepsy ◽  
Major Advance ◽  
New Antiepileptic Drugs ◽  
Life Threatening ◽  
Titration Schedule

Lamotrigine, like all antiepileptic drugs, can be effective when used as monotherapy or adjunctive therapy. In general, adverse effects are reduced when monotherapy is employed. The most frequent adverse effect prompting withdrawal of lamotrigine is rash. This potentially life-threatening adverse effect occurs more frequently in children, is increased when a rapid dose titration schedule is employed, and is greater when lamotrigine is prescribed in combination with valproate. The availability of lamotrigine and other antiepileptic drugs represents a major advance for the treatment of childhood epilepsy. The challenge in using all of the new antiepileptic drugs, including lamotrigine, is to balance the expected improved efficacy with the potentially serious adverse effects. (J Child Neurol 1997;12(Suppl 1):S48-S52).

scholarly journals Association between Adverse Effects and Parental Beliefs about Antiepileptic Medicines

Medicina ◽  
2018 ◽  
Vol 54 (4) ◽  
pp. 60 ◽  
Author(s):  
Violeta Ilić ◽  
Dragana Bogićević ◽  
Branislava Miljković ◽  
Sandra Vezmar-Kovačević
Keyword(s):  
Adverse Effects ◽  
Antiepileptic Drugs ◽  
Parental Education ◽  
Febrile Seizures ◽  
Parental Beliefs ◽  
Parental Concerns ◽  
Upset Stomach ◽  
Antiepileptic Medications ◽  
The University ◽  
Beliefs About Medications

Background and Aim: Adverse effects are common in children treated with antiepileptic medications and may affect parental beliefs about treatment. The aim of the study was to investigate the relationship between adverse effects and parental beliefs about antiepileptic drugs used for the treatment of their children. Methods: The study was performed at the University Children’s Hospital, Belgrade, Serbia from 2013–2015. Parents of children treated with valproic acid, carbamazepine or lamotrigine, were eligible. They were asked to fill in the Beliefs about Medications Questionnaire (BMQ) and The Liverpool Adverse Events Profile (LAEP). Results: Parents of 127 children (average age 9.88 ± 4.16 years) of whom 111 had epilepsy (67 generalized, 44 focal) and 16 with febrile seizures participated in the study. Nervousness and/or agitation, weight gain, restlessness, headache, difficulty in concentrating, feeling of aggression and upset stomach were most frequent adverse effects, reported in 37% of the population. BMQ-specific necessity scores significantly correlated with parental education; parents with elementary school showed lower scores than those with higher education. The presence of difficulty in concentrating of their child was associated with higher BMQ concern scores (20.73 ± 4.25 vs. 18.99 ± 3.60, p = 0.043) as well as necessity scores (18.42 ± 3.31 vs. 16.40 ± 2.73, p = 0.017). Higher scores of BMQ-general overuse were reported in the presence of a headache (8.79 ± 2.81 vs. 7.64 ± 2.72, p = 0.027). Conclusions: The main finding of our study is that parental beliefs about antiepileptic drugs were associated with the presence of adverse effects. Understanding this relationship could allow physicians and pharmacists to structure better educational programs for parents of children treated with antiepileptic drugs. Education should be more focused towards understanding the adverse effects of antiepileptics which could alleviate parental concerns and strengthen their beliefs about the necessity of medication use in their children.

Strategies to detect adverse effects of antiepileptic drugs in clinical practice

2008 ◽  
Vol 13 (1) ◽  
pp. 178-183 ◽  
Author(s):  
M. Carreño ◽  
A. Gil-Nagel ◽  
J.C. Sánchez ◽  
E. Elices ◽  
J.M. Serratosa ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Adverse Effects ◽  
Antiepileptic Drugs

scholarly journals Determining risk factors of developing adverse effects of antiepileptic drugs in epileptic patients

2019 ◽  
Vol 405 ◽  
pp. 141
Author(s):  
S. Mrabet ◽  
K. Moalla ◽  
A. Nasri ◽  
I. Kacem ◽  
M. Djebara ◽  
...  
Keyword(s):  
Risk Factors ◽  
Adverse Effects ◽  
Antiepileptic Drugs ◽  
Epileptic Patients

scholarly journals Severity of anxiety and depression are related to a higher perception of adverse effects of antiepileptic drugs

Seizure ◽  
2012 ◽  
Vol 21 (8) ◽  
pp. 588-594 ◽  
Author(s):  
Bety Gómez-Arias ◽  
Daniel Crail-Meléndez ◽  
Rosario López-Zapata ◽  
Iris E. Martínez-Juárez
Keyword(s):  
Adverse Effects ◽  
Antiepileptic Drugs ◽  
Anxiety And Depression

scholarly journals Women's Issues in the Treatment of Epilepsy

1998 ◽  
Vol 25 (S4) ◽  
pp. S19-S23 ◽  
Author(s):  
J. Bruni
Keyword(s):  
Sexual Dysfunction ◽  
Adverse Effects ◽  
Antiepileptic Drugs ◽  
Seizure Frequency ◽  
Seizure Control ◽  
Teratogenic Effects ◽  
New Agents ◽  
Advantages And Disadvantages ◽  
New Antiepileptic Drugs ◽  
Management Issues

ABSTRACT:Background:The management of women with epilepsy involves a number of important issues including conception control, sexual dysfunction and fertility, the effect of seizures on the fetus, possible changes in seizure frequency during pregnancy, potential teratogenic effects of antiepileptic drugs and management issues during pregnancy. The primary goal in the treatment of women with epilepsy remains optimal seizure control in the absence of unacceptable adverse effects. The advantages and disadvantages of the new antiepileptic drugs in women remain to be fully established but these new agents allow a wider choice for improved seizure control

Adverse Effects of Antiepileptic Drugs in North Indian Pediatric Outpatients

2013 ◽  
Vol 36 (4) ◽  
pp. 107-113 ◽  
Author(s):  
Dipika Bansal ◽  
Chandrika Azad ◽  
Manpreet Kaur ◽  
Neelima Rudroju ◽  
Pravallika Vepa ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Antiepileptic Drugs ◽  
Indian Pediatric ◽  
Pediatric Outpatients
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