Adverse Effects of Antiepileptic Drugs in North Indian Pediatric Outpatients

2013 ◽  
Vol 36 (4) ◽  
pp. 107-113 ◽  
Author(s):  
Dipika Bansal ◽  
Chandrika Azad ◽  
Manpreet Kaur ◽  
Neelima Rudroju ◽  
Pravallika Vepa ◽  
...  
1997 ◽  
Vol 12 (1_suppl) ◽  
pp. S48-S52 ◽  
Author(s):  
John M. Pellock

Lamotrigine, like all antiepileptic drugs, can be effective when used as monotherapy or adjunctive therapy. In general, adverse effects are reduced when monotherapy is employed. The most frequent adverse effect prompting withdrawal of lamotrigine is rash. This potentially life-threatening adverse effect occurs more frequently in children, is increased when a rapid dose titration schedule is employed, and is greater when lamotrigine is prescribed in combination with valproate. The availability of lamotrigine and other antiepileptic drugs represents a major advance for the treatment of childhood epilepsy. The challenge in using all of the new antiepileptic drugs, including lamotrigine, is to balance the expected improved efficacy with the potentially serious adverse effects. (J Child Neurol 1997;12(Suppl 1):S48-S52).


Medicina ◽  
2018 ◽  
Vol 54 (4) ◽  
pp. 60 ◽  
Author(s):  
Violeta Ilić ◽  
Dragana Bogićević ◽  
Branislava Miljković ◽  
Sandra Vezmar-Kovačević

Background and Aim: Adverse effects are common in children treated with antiepileptic medications and may affect parental beliefs about treatment. The aim of the study was to investigate the relationship between adverse effects and parental beliefs about antiepileptic drugs used for the treatment of their children. Methods: The study was performed at the University Children’s Hospital, Belgrade, Serbia from 2013–2015. Parents of children treated with valproic acid, carbamazepine or lamotrigine, were eligible. They were asked to fill in the Beliefs about Medications Questionnaire (BMQ) and The Liverpool Adverse Events Profile (LAEP). Results: Parents of 127 children (average age 9.88 ± 4.16 years) of whom 111 had epilepsy (67 generalized, 44 focal) and 16 with febrile seizures participated in the study. Nervousness and/or agitation, weight gain, restlessness, headache, difficulty in concentrating, feeling of aggression and upset stomach were most frequent adverse effects, reported in 37% of the population. BMQ-specific necessity scores significantly correlated with parental education; parents with elementary school showed lower scores than those with higher education. The presence of difficulty in concentrating of their child was associated with higher BMQ concern scores (20.73 ± 4.25 vs. 18.99 ± 3.60, p = 0.043) as well as necessity scores (18.42 ± 3.31 vs. 16.40 ± 2.73, p = 0.017). Higher scores of BMQ-general overuse were reported in the presence of a headache (8.79 ± 2.81 vs. 7.64 ± 2.72, p = 0.027). Conclusions: The main finding of our study is that parental beliefs about antiepileptic drugs were associated with the presence of adverse effects. Understanding this relationship could allow physicians and pharmacists to structure better educational programs for parents of children treated with antiepileptic drugs. Education should be more focused towards understanding the adverse effects of antiepileptics which could alleviate parental concerns and strengthen their beliefs about the necessity of medication use in their children.


2008 ◽  
Vol 13 (1) ◽  
pp. 178-183 ◽  
Author(s):  
M. Carreño ◽  
A. Gil-Nagel ◽  
J.C. Sánchez ◽  
E. Elices ◽  
J.M. Serratosa ◽  
...  

2019 ◽  
Vol 405 ◽  
pp. 141
Author(s):  
S. Mrabet ◽  
K. Moalla ◽  
A. Nasri ◽  
I. Kacem ◽  
M. Djebara ◽  
...  

Seizure ◽  
2012 ◽  
Vol 21 (8) ◽  
pp. 588-594 ◽  
Author(s):  
Bety Gómez-Arias ◽  
Daniel Crail-Meléndez ◽  
Rosario López-Zapata ◽  
Iris E. Martínez-Juárez

Author(s):  
J. Bruni

ABSTRACT:Background:The management of women with epilepsy involves a number of important issues including conception control, sexual dysfunction and fertility, the effect of seizures on the fetus, possible changes in seizure frequency during pregnancy, potential teratogenic effects of antiepileptic drugs and management issues during pregnancy. The primary goal in the treatment of women with epilepsy remains optimal seizure control in the absence of unacceptable adverse effects. The advantages and disadvantages of the new antiepileptic drugs in women remain to be fully established but these new agents allow a wider choice for improved seizure control


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