The effects of passive antibodies to egg albumin on active immunity in lambs to Brucella abortus and egg albumin

1978 ◽  
Vol 25 (1) ◽  
pp. 63-66 ◽  
Author(s):  
M.R. Williams ◽  
R. Halliday ◽  
A.R. MacLeod
1964 ◽  
Vol 161 (983) ◽  
pp. 208-215 ◽  

Killed Brucella abortus was injected into young rats. Specific agglutinins were first detected at 10 days of age in all groups of rats injected between birth and 4 days and were present in all 14-day-old rats. Rats receiving injections at 16 days or later produced agglutinins as quickly as adults, although the titres present after comparable periods increased rapidly with the age at injection until 1 month of age, and more slowly afterwards. The ages during which agglutinins first appear in the suckling rat correspond closely to those during which there is a sharp decline in mortality, suggesting that the active immune response is of protective value even during the period of active absorption of maternal globulin.


Ultracentrifugation in a gradient of sucrose and subsequent fractionation has been used to determine the distribution of antibody activity between the heavy and light components of the immune sera of rabbits. The agglutinins to Brucella abortus in the sera of hyperimmune rabbits, which are transmitted readily to the foetuses, are in the light component and none are detectable in the macroglobulin. A macroglobulin component is present in the sera of rabbit foetuses of 22, 25 and 28 days of gestation and tends to increase with foetal age and to be more pronounced at 28 days than in the adult. The agglutinins to human red cells of Group A in rabbits immunized during pregnancy and killed on the 26th day of gestation are present in, and apparently confined to, the macroglobulin component of the foetal, as well as of the maternal, sera. This observation confirms the previous conclusion that agglutinins in both the heavy and light components of immune rabbit sera are transmitted readily from mother to foetus and that molecular size does not play an important part in the transmission of active immunity before birth in the rabbit.


2009 ◽  
Vol 8 (1) ◽  
pp. 48-59
Author(s):  
A M.J ◽  
A S.S ◽  
A I.A ◽  
A Al-Oubaidy ◽  
A Alwan ◽  
...  

Author(s):  
Justin Farrell

This chapter examines the bitter, long-lasting, and sometimes violent dispute over the Yellowstone bison herd—America's only remaining genetically pure and free-roaming herd, which once numbered more than 30 million but was exterminated down to a mere 23 single animals. This intractable issue hinges on current scientific disagreements about the biology and ecology of the disease brucellosis (Brucella abortus). But in recent years, a more radical, grassroots, and direct action activist group called the Buffalo Field Campaign (BFC) has found success by shifting the focus of the debate away from science, toward the deeper religious dimensions of the issue. The chapter shows how the infusion of the conflict with moral and spiritual feeling has brought to the fore deeper questions that ultimately needed to be answered, thus making this a public religious conflict as much as a scientific one, sidestepping rabbit holes of intractability. It observes the ways in which BFC activists engaged in a phenomenon called moral and religious “muting.” This has theoretical implications for understanding how certain elements of culture (e.g., individualism and moral relativism) can organize and pattern others—especially in post hoc explanations of religiously motivated activism.


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