scholarly journals Enantioselective total syntheses of the novel tricyclic sesquiterpene hydrocarbons (+)- and (−)-kelsoene. Absolute configuration of the natural product

2001 ◽  
Vol 42 (15) ◽  
pp. 2855-2857 ◽  
Author(s):  
Goverdhan Mehta ◽  
K Srinivas
Keyword(s):  
Natural Product ◽  
Absolute Configuration ◽  
The Novel ◽  
Total Syntheses ◽  
Sesquiterpene Hydrocarbons

scholarly journals Nano-evolution and protein-based enzymatic evolution predicts the novel types of natural product nanozyme of traditional Chinese medicine: cases of herbzymes of Taishan-Huangjing (Rhizoma polygonati) and Goji (Lycium chinense)

2021 ◽  
Author(s):  
Guldan Nazarbek ◽  
Aidana Kutzhanova ◽  
Lazzat Nurtay ◽  
Chenglin Mu ◽  
Bexultan Kazybay ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Natural Product ◽  
Enzyme Function ◽  
The Novel ◽  
Lycium Chinense ◽  
Natural Protein

Nanozyme and natural product-derived herbzyme have been identified in different enzyme types simulating the natural protein-based enzyme function. How to explore and predict enzyme types of novel nanozyme when synthesized...

scholarly journals Total Syntheses of Pladienolide-Derived Spliceosome Modulators

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5938
Author(s):  
Jaehoon Sim ◽  
Eunbin Jang ◽  
Hyun Jin Kim ◽  
Hongjun Jeon
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Structural Features ◽  
Synthetic Approach ◽  
Synthetic Analog ◽  
Phase I Clinical Trials ◽  
Total Syntheses ◽  
Naturally Occurring ◽  
Anti Cancer ◽  
Synthetic Approaches

Pladienolides, an emerging class of naturally occurring spliceosome modulators, exhibit interesting structural features, such as highly substituted 12-membered macrocycles and epoxide-containing diene side chains. The potential of pladienolides as anti-cancer agents is confirmed by H3B-8800, a synthetic analog of this natural product class, which is currently under Phase I clinical trials. Since its isolation in 2004 and the first total synthesis in 2007, a dozen total syntheses and synthetic approaches toward the pladienolide class have been reported to date. This review focuses on the eight completed total syntheses of naturally occurring pladienolides or their synthetic analogs, in addition to a synthetic approach to the main framework of the natural product.

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