Concise total synthesis of the prolyl endopeptidase inhibitor eurystatin A via a novel Passerini reaction–deprotection–acyl migration strategy

Tetrahedron Letters ◽

10.1016/s0040-4039(01)01287-4 ◽

2001 ◽

Vol 42 (36) ◽

pp. 6271-6274 ◽

Author(s):

Timothy D Owens ◽

Gian-Luca Araldi ◽

Ruth F Nutt ◽

J.Edward Semple

Keyword(s):

Total Synthesis ◽

Acyl Migration ◽

Prolyl Endopeptidase ◽

Passerini Reaction ◽

Migration Strategy ◽

Prolyl Endopeptidase Inhibitor

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ChemInform Abstract: Concise Total Synthesis of the Prolyl Endopeptidase Inhibitor Eurystatin A (I) via a Novel Passerini Reaction-Deprotection-Acyl Migration Strategy.

10.1002/chin.200146203 ◽

2010 ◽

Vol 32 (46) ◽

pp. no-no

Author(s):

Timothy D. Owens ◽

Gian-Luca Araldi ◽

Ruth F. Nutt ◽

J. Edward Semple

Keyword(s):

Total Synthesis ◽

Acyl Migration ◽

Prolyl Endopeptidase ◽

Passerini Reaction ◽

Migration Strategy ◽

Prolyl Endopeptidase Inhibitor

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ChemInform Abstract: Atom-Economical Synthesis of the N(10)-C(17) Fragment of Cyclotheonamides via a Novel Passerini Reaction-Deprotection-Acyl Migration Strategy.

10.1002/chin.200208211 ◽

2010 ◽

Vol 33 (8) ◽

pp. no-no

Author(s):

Timothy D. Owens ◽

J. Edward Semple

Keyword(s):

Acyl Migration ◽

Passerini Reaction ◽

Migration Strategy

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O—N Intramolecular Acyl Migration Strategy in Water-Soluble Prodrugs of Taxoids.

10.1002/chin.200413145 ◽

2004 ◽

Vol 35 (13) ◽

Author(s):

Mariusz Skwarczynski ◽

Youhei Sohma ◽

Maiko Kimura ◽

Yoshio Hayashi ◽

Tooru Kimura ◽

...

Keyword(s):

Acyl Migration ◽

Water Soluble ◽

Migration Strategy

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ChemInform Abstract: Rearrangement Approaches to Cyclic Skeletons. Part 6. Total Synthesis of (.+-.)-Ptilocaulin on the Basis of Formal Bridgehead Substitution and Photochemical (1,3) Acyl Migration of a Bicyclo(3.2.2)non-6-en-2-one System.

10.1002/chin.198906322 ◽

1989 ◽

Vol 20 (6) ◽

Author(s):

T. UYEHARA ◽

T. FURUTA ◽

Y. KABAWAWA ◽

J. YAMADA ◽

T. KATO ◽

...

Keyword(s):

Total Synthesis ◽

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Effect of Imipramine and Prolyl Endopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on Activity of Proline-Specific Peptidases in the Brain of Rats with Experimental Anxious-Depressive Syndrome

Bulletin of Experimental Biology and Medicine ◽

10.1007/s10517-012-1540-z ◽

2012 ◽

Vol 152 (4) ◽

pp. 409-412 ◽

Author(s):

N. N. Khlebnikova ◽

N. A. Krupina ◽

E. Yu. Kushnareva ◽

N. N. Zolotov ◽

G. N. Kryzhanovskii

Keyword(s):

Prolyl Endopeptidase ◽

Depressive Syndrome ◽

Prolyl Endopeptidase Inhibitor ◽

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Atom-Economical Synthesis of the N(10)−C(17) Fragment of Cyclotheonamides via a Novel Passerini Reaction−Deprotection−Acyl Migration Strategy1

Organic Letters ◽

10.1021/ol0165239 ◽

2001 ◽

Vol 3 (21) ◽

pp. 3301-3304 ◽

Author(s):

Timothy D. Owens ◽

J. Edward Semple

Keyword(s):

Acyl Migration ◽

Passerini Reaction

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From protein total synthesis to peptide transamidation and metathesis: playing with the reversibility of N,S-acyl or N,Se-acyl migration reactions

Current Opinion in Chemical Biology ◽

10.1016/j.cbpa.2014.09.030 ◽

2014 ◽

Vol 22 ◽

pp. 137-145 ◽

Author(s):

Oleg Melnyk ◽

Vangelis Agouridas

Keyword(s):

Total Synthesis ◽

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Prolyl endopeptidase inhibitor Y-29794 blocks the IRS1-AKT-mTORC1 pathway and inhibits survival and in vivo tumor growth of triple-negative breast cancer

Cancer Biology & Therapy ◽

10.1080/15384047.2020.1824989 ◽

2020 ◽

Vol 21 (11) ◽

pp. 1033-1040

Author(s):

Ricardo E Perez ◽

Sarah Calhoun ◽

Daeun Shim ◽

Victor V. Levenson ◽

Lei Duan ◽

...

Keyword(s):

Breast Cancer ◽

Tumor Growth ◽

Triple Negative Breast Cancer ◽

Triple Negative ◽

Prolyl Endopeptidase ◽

Prolyl Endopeptidase Inhibitor ◽

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Pharmacodynamic and pharmacokinetic profile of S 17092, a new orally active prolyl endopeptidase inhibitor, in elderly healthy volunteers. A phase I study

British Journal of Clinical Pharmacology ◽

10.1046/j.1365-2125.2000.00270.x ◽

2000 ◽

Vol 50 (4) ◽

pp. 350-359 ◽

Author(s):

P. Morain ◽

J. L. Robin ◽

G. De Nanteuil ◽

R. Jochemsen ◽

V. Heidet ◽

...

Keyword(s):

Phase I ◽

Healthy Volunteers ◽

Phase I Study ◽

Pharmacokinetic Profile ◽

Prolyl Endopeptidase ◽

Prolyl Endopeptidase Inhibitor ◽

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Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on spatial memory and on cholinergic and peptidergic neurons in rats with ibotenate-induced lesions of the nucleus basalis magnocellularis

Behavioural Brain Research ◽

10.1016/s0166-4328(98)00005-9 ◽

1999 ◽

Vol 99 (1) ◽

pp. 17-25 ◽

Author(s):

Masahiko Shinoda ◽

Akira Miyazaki ◽

Katsuo Toide

Keyword(s):

Spatial Memory ◽

Prolyl Endopeptidase ◽

Nucleus Basalis ◽

Nucleus Basalis Magnocellularis ◽

Peptidergic Neurons ◽

Prolyl Endopeptidase Inhibitor

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