O—N Intramolecular Acyl Migration Strategy in Water-Soluble Prodrugs of Taxoids.

ChemInform ◽  
2004 ◽  
Vol 35 (13) ◽  
Author(s):  
Mariusz Skwarczynski ◽  
Youhei Sohma ◽  
Maiko Kimura ◽  
Yoshio Hayashi ◽  
Tooru Kimura ◽  
...  
Keyword(s):  
Acyl Migration ◽  
Water Soluble ◽  
Migration Strategy

O–N Intramolecular acyl migration strategy in water-soluble prodrugs of taxoids

2003 ◽  
Vol 13 (24) ◽  
pp. 4441-4444 ◽  
Author(s):  
Mariusz Skwarczynski ◽  
Youhei Sohma ◽  
Maiko Kimura ◽  
Yoshio Hayashi ◽  
Tooru Kimura ◽  
...  
Keyword(s):  
Acyl Migration ◽  
Water Soluble ◽  
Migration Strategy

Water-soluble prodrugs of dipeptide HIV protease inhibitors based on O→N intramolecular acyl migration: Design, synthesis and kinetic study

2004 ◽  
Vol 12 (1) ◽  
pp. 159-170 ◽  
Author(s):  
Yoshio Hamada ◽  
Hikaru Matsumoto ◽  
Satoshi Yamaguchi ◽  
Tooru Kimura ◽  
Yoshio Hayashi ◽  
...  
Keyword(s):  
Kinetic Study ◽  
Protease Inhibitors ◽  
Acyl Migration ◽  
Water Soluble ◽  
Hiv Protease ◽  
Hiv Protease Inhibitors ◽  
Design Synthesis

Effect of the acyl groups on O→N acyl migration in the water-soluble prodrugs of HIV-1 protease inhibitor

2003 ◽  
Vol 13 (16) ◽  
pp. 2727-2730 ◽  
Author(s):  
Yoshio Hamada ◽  
Hikaru Matsumoto ◽  
Tooru Kimura ◽  
Yoshio Hayashi ◽  
Yoshiaki Kiso
Keyword(s):  
Protease Inhibitor ◽  
Acyl Migration ◽  
Water Soluble ◽  
Hiv 1

New water-soluble prodrugs of HIV protease inhibitors based on O→N intramolecular acyl migration

2002 ◽  
Vol 10 (12) ◽  
pp. 4155-4167 ◽  
Author(s):  
Yoshio Hamada ◽  
Jun Ohtake ◽  
Youhei Sohma ◽  
Tooru Kimura ◽  
Yoshio Hayashi ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Acyl Migration ◽  
Water Soluble ◽  
Hiv Protease ◽  
Hiv Protease Inhibitors

A Resorcinol-Formaldehyde Resin as an Embedding Material for Electron Microscopy of Membranes

1969 ◽  
Vol 27 ◽  
pp. 328-329 ◽  
Author(s):  
J. G. Robertson ◽  
D. F. Parsons
Keyword(s):  
Electron Microscopy ◽  
Osmium Tetroxide ◽  
Neutral Lipids ◽  
Lipid Extraction ◽  
Water Soluble ◽  
Formaldehyde Resin ◽  
Electron Microscope Autoradiography ◽  
Resorcinol Formaldehyde ◽  
Major Disadvantage ◽  
Cell Organization

The extraction of lipids from tissues during fixation and embedding for electron microscopy is widely recognized as a source of possible artifact, especially at the membrane level of cell organization. Lipid extraction is also a major disadvantage in electron microscope autoradiography of radioactive lipids, as in studies of the uptake of radioactive fatty acids by intestinal slices. Retention of lipids by fixation with osmium tetroxide is generally limited to glycolipids, phospholipids and highly unsaturated neutral lipids. Saturated neutral lipids and sterols tend to be easily extracted by organic dehydrating reagents prior to embedding. Retention of the more saturated lipids in embedded tissue might be achieved by developing new cross-linking reagents, by the use of highly water soluble embedding materials or by working at very low temperatures.

Ferritin Labeled Antibody Staining of Thin Sections

1969 ◽  
Vol 27 ◽  
pp. 420-421
Author(s):  
J. D. McLean ◽  
S. J. Singer
Keyword(s):  
Biological Material ◽  
Water Soluble ◽  
Thin Sections ◽  
Antibody Staining ◽  
Thin Sectioning ◽  
Ultrathin Sections

The successful application of ferritin labeled antibodies (F-A) to ultrathin sections of biological material has been hampered by two main difficulties. Firstly the normally used procedures for the preparation of material for thin sectioning often result in a loss of antigenicity. Secondly the polymers employed for embedding may non-specifically absorb the F-A. Our earlier use of cross-linked polyampholytes as embedding media partially overcame these problems. However the water-soluble monomers used for this method still extract many lipids from the material.

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