The effect of donor gender on renal allograft survival and influence of donor age on posttransplant graft outcome and patient survival

1997 ◽  
Vol 29 (8) ◽  
pp. 3371-3372 ◽  
Author(s):  
F. Valdes ◽  
S. Pita ◽  
A. Alonso ◽  
C.F. Rivera ◽  
M. Cao ◽  
...  
Keyword(s):  
Renal Allograft ◽  
Patient Survival ◽  
Donor Age ◽  
Allograft Survival ◽  
Graft Outcome

scholarly journals Contribution of Prolonged Ischemia and Donor Age to Chronic Renal Allograft Dysfunction

2000 ◽  
Vol 11 (7) ◽  
pp. 1317-1324
Author(s):  
STEFAN GÜNTHER TULLIUS ◽  
ANJA REUTZEL-SELKE ◽  
FRANK EGERMANN ◽  
MELINA NIEMINEN-KELHÄ ◽  
SVEN JONAS ◽  
...  
Keyword(s):  
Structural Changes ◽  
Renal Allograft ◽  
Donor Age ◽  
Fischer 344 ◽  
Graft Outcome ◽  
Age Related ◽  
The Impact ◽  
Functional Deterioration ◽  
Observation Period

Abstract. As a consequence of an advancing discrepancy between supply of suitable grafts and demand from potential recipients, less than optimal organs are increasingly being used. Although clinical studies demonstrate the involvement of various risk factors, including donor age and duration of ischemia on long-term graft outcome, their individual contribution and correlation has not been followed experimentally. After cold ischemic times of 5, 60, and 120 min, kidney allografts of 3-, 12-, and 18-mo-old Fischer 344 donors were transplanted into 3-mo-old Lewis rats. Age-related changes were examined in matched native uninephrectomized controls. Proteinuria and creatinine clearance were determined, and histologic and immunohistologic studies were assessed and quantified at the end of the observation period (20 wk). All grafts functioned satisfactorily with the exception of one graft each from 12- and 18-mo-old donors with prolonged ischemia (120 min). Functional deterioration and structural changes progressed in parallel to increasing donor age and prolonged ischemia. The impact of expanded ischemia was particularly detrimental in grafts from older donor animals. Donor age and duration of ischemia act in a synergistic manner in our model. Brief ischemic times seem of particular relevance when grafts from older donors are being used.

End-Stage Kidney Disease Due to Fibrillary Glomerulonephritis and Immunotactoid Glomerulopathy - Outcomes in 66 Consecutive ANZDATA Registry Cases

2015 ◽  
Vol 42 (3) ◽  
pp. 177-184 ◽  
Author(s):  
Andrew Mallett ◽  
Wen Tang ◽  
Gareth Hart ◽  
Stephen P. McDonald ◽  
Carmel M. Hawley ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Kidney Disease ◽  
Renal Allograft ◽  
Patient Survival ◽  
Allograft Survival ◽  
End Stage Kidney Disease ◽  
Fibrillary Glomerulonephritis ◽  
Renal Allografts ◽  
Immunotactoid Glomerulopathy ◽  
End Stage

Background: Fibrillary glomerulonephritis (FGN) and immunotactoid glomerulopathy (IG) are uncommon and characterised by non-amyloid fibrillary glomerular deposits. The aim of this study was to investigate characteristics and outcomes of patients undergoing renal replacement therapy (RRT) for end-stage kidney disease (ESKD) secondary to FGN and IG. Methods: All ESKD patients who commenced RRT in Australia and New Zealand 1 January 1990 to 31 December 2010 were included. Outcomes were assessed by Kaplan-Meier, multivariate logistic-regression analysis and multivariable Cox proportional-hazards survival analysis. Results: Of 45,216 individuals with ESKD, 55 (0.12%) had FGN and 11 (0.02%) had IG. The median survival of FGN patients on dialysis (5.63 years, 95% CI 3.31-7.96) was not significantly different from patients with other ESKD causes (median 4.01 years, 95% CI 4.34-4.47; log-rank 1.32, p = 0.25), but was significantly longer than that of IG patients (median 2.93 years, 95% CI 0.00-6.17; log-rank 4.8, p = 0.03). Thirteen (24%) FGN patients received 13 renal-allografts, 4 (36%) IG patients received 4 renal-allografts and 11,528 (26%) other ESKD patients received 12,278 renal-allografts. FGN patients experienced comparable outcomes to other ESKD patients for both 10-year patient survival (100 vs. 84%, p = 0.93) and renal-allograft survival (67 vs. 76%, p = 0.06). For IG, the median follow-up was 3.66 years with 75% patient survival and 100% renal-allograft survival. One (8%) FGN patient and 1 (25%) IG patient experienced recurrent FGN and IG respectively in their allograft. Conclusion: Patients with FGN have comparable dialysis and renal transplant outcomes to patients with other causes of ESKD. IG patients have inferior survival on dialysis, although renal transplant outcomes are acceptable. Disease recurrence in renal-allografts was low for both FGN and IG.

Effect of donor age on renal allograft survival

1998 ◽  
Vol 30 (7) ◽  
pp. 3660-3661 ◽  
Author(s):  
H Degawa ◽  
T Nemoto ◽  
M Uchiyama ◽  
K Kozaki ◽  
N Matsuno ◽  
...  
Keyword(s):  
Renal Allograft ◽  
Donor Age ◽  
Allograft Survival

scholarly journals The Relationship Between Donor Age and Cadaveric Renal Allograft Survival Is Modified by the Recipient's Blood Pressure

2003 ◽  
Vol 3 (3) ◽  
pp. 340-347 ◽  
Author(s):  
Fernando G. Cosio ◽  
Mitchell Henry ◽  
Todd E. Pesavento ◽  
Ronald M. Ferguson ◽  
Sunny Kim ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Allograft ◽  
Donor Age ◽  
Allograft Survival ◽  
The Relationship

scholarly journals Improved renal allograft survival for pre-emptive paediatric renal transplant recipients in the UK

2021 ◽  
pp. archdischild-2020-321277
Author(s):  
Matko Marlais ◽  
Kate Martin ◽  
Stephen D Marks
Keyword(s):  
Peritoneal Dialysis ◽  
Renal Transplant ◽  
Renal Allograft ◽  
Cox Regression ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Allograft Survival ◽  
Significant Difference ◽  
Donor Type ◽  
The Uk

BackgroundThe aim of this study was to investigate whether being on dialysis at the time of renal transplantation affected renal allograft survival in paediatric renal transplant recipients (pRTRs).MethodsRetrospective study of UK Transplant Registry (National Health Service Blood and Transplant) data on all children (aged <18 years) receiving a kidney-only transplant from 1 January 2000 to 31 December 2015. Kaplan-Meier estimates of patient and renal allograft survival calculated and Cox regression modelling accounting for donor type. The relationship between time on dialysis and renal allograft survival was examined.Results2038 pRTRs were analysed: 607 (30%) were pre-emptively transplanted, 789 (39%) and 642 (32%) on peritoneal dialysis and haemodialysis, respectively, at the time of transplantation. Five-year renal allograft survival was significantly better in the pre-emptively transplanted group (90.6%) compared with those on peritoneal dialysis and haemodialysis (86.4% and 85.7%, respectively; p=0.02). After accounting for donor type, there was a significantly lower hazard of 5-year renal allograft failure in pre-emptively transplanted children (HR 0.742, p=0.05). Time spent on dialysis pre-transplant negatively correlated with renal allograft survival (p=0.002). There was no significant difference in 5-year renal allograft survival between children who were on dialysis for less than 6 months and children transplanted pre-emptively (87.5% vs 90.5%, p=0.25).ConclusionsPre-emptively transplanted children have improved 5-year renal allograft survival, compared with children on dialysis at the time of transplantation. Although increased time spent on dialysis correlated with poorer renal allograft survival, there was no evidence that short periods of dialysis pre-transplant affected renal allograft survival.

scholarly journals Outcomes of Kidney Transplant Recipients with Sickle Cell Disease: An Analysis of the 2000–2019 UNOS/OPTN Database

2021 ◽  
Vol 10 (14) ◽  
pp. 3063
Author(s):  
Napat Leeaphorn ◽  
Charat Thongprayoon ◽  
Pradeep Vaitla ◽  
Panupong Hansrivijit ◽  
Caroline C. Jadlowiec ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Graft Survival ◽  
Patient Survival ◽  
Transplant Recipients ◽  
Cell Disease ◽  
Kidney Transplant Recipients ◽  
Allograft Survival ◽  
End Stage Kidney Disease ◽  
Kidney Recipients ◽  
End Stage

Background: Lower patient survival has been observed in sickle cell disease (SCD) patients who go on to receive a kidney transplant. This study aimed to assess the post-transplant outcomes of SCD kidney transplant recipients in the contemporary era. Methods: We used the OPTN/UNOS database to identify first-time kidney transplant recipients from 2010 through 2019. We compared patient and allograft survival between recipients with SCD (n = 105) vs. all other diagnoses (non-SCD, n = 146,325) as the reported cause of end-stage kidney disease. We examined whether post-transplant outcomes improved among SCD in the recent era (2010–2019), compared to the early era (2000–2009). Results: After adjusting for differences in baseline characteristics, SCD was significantly associated with lower patient survival (HR 2.87; 95% CI 1.75–4.68) and death-censored graft survival (HR 1.98; 95% CI 1.30–3.01), compared to non-SCD recipients. The lower patient survival and death-censored graft survival in SCD recipients were consistently observed in comparison to outcomes of recipients with diabetes, glomerular disease, and hypertension as the cause of end-stage kidney disease. There was no significant difference in death censored graft survival (HR 0.99; 95% CI 0.51–1.73, p = 0.98) and patient survival (HR 0.93; 95% CI 0.50–1.74, p = 0.82) of SCD recipients in the recent versus early era. Conclusions: Patient and allograft survival in SCD kidney recipients were worse than recipients with other diagnoses. Overall SCD patient and allograft outcomes in the recent era did not improve from the early era. The findings of our study should not discourage kidney transplantation for ESKD patients with SCD due to a known survival benefit of transplantation compared with remaining on dialysis. Urgent future studies are needed to identify strategies to improve patient and allograft survival in SCD kidney recipients. In addition, it may be reasonable to assign risk adjustment for SCD patients.

FAILURE OF BLOOD TRANSFUSIONS TO IMPROVE CADAVERIC RENAL ALLOGRAFT SURVIVAL

1978 ◽  
Vol 25 (6) ◽  
pp. 344 ◽  
Author(s):  
JOHN R. JEFFERY ◽  
ALLAN DOWNS ◽  
J. WILSON GRAHAME ◽  
CHARLES LYE ◽  
ERNEST RAMSEY ◽  
...  
Keyword(s):  
Renal Allograft ◽  
Blood Transfusions ◽  
Allograft Survival
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