The pollution of water bodies by an excess of nutrients (N and P) is a worldwide problem with effects on the human health, ecosystems status, climate change, etc. To face with this important issue different regulations were promulgated by the countries, sometimes based on the results from international conventions and programmes. In this chapter, a review of the laws and regulations that affect the discharge of nitrogen and phosphorus is addressed, focused in the case of Europe and the United States. Finally, a brief explanation about international initiatives was performed to understand the global framework concerning nutrients pollution.