Diagnostic Value of the Nycocard®, Nycomed® D-Dimer Assay for the Diagnosis of Deep Venous Thrombosis and Pulmonary Embolism

2000 ◽  
Vol 100 (4) ◽  
pp. 287-292 ◽  
Author(s):  
Rikke Hein-Rasmussen ◽  
Christian D Tuxen ◽  
Niels Wiinberg
Keyword(s):  
Pulmonary Embolism ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Diagnostic Value ◽  
D Dimer

DIAGNOSTIC VALUE OF D-DIMER, FIBRINOGEN DEGRADATION PRODUCTS, ETHANOL GEL TEST AND TRANSFER TEST IN DEEP VENOUS THROMBOSIS AND PULMONARY EMBOLISM

1987 ◽  
Author(s):  
D Wachel ◽  
M Segers ◽  
P Leautaud ◽  
J J Rodzynek
Keyword(s):  
Pulmonary Embolism ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Transfer Test ◽  
Degradation Products ◽  
Diagnostic Value ◽  
Predictive Values ◽  
Thrombotic Disease ◽  
Emergency Situations ◽  
D Dimer

In order to determine the sensitivity and the specificity of laboratory tests in the diagnosis of thrombotic disease, D-Dimer (D-D) latex, Fibrin(ogen) Degradation Products (FDP), Ethanol Gel Test (EGT) and Transfer Test (TT) were performed in two groups of patients : group 1 = 199 consecutive patients without thrombotic disease, group 2 = 56 patients with thrombosis (Deep Venous Thrombosis confirmed by radiological phlebography, n=19, and Pulmonary Embolism confirmed by ventilation-perfusion lung scintigraphy, n=37). The sensitivity, the specificity, the positive and negative predictive values (PV+ and PV-) for the different tests appeared as follows :Conclusion :1) Among the different parameters which have been studied, D-Dimer latex appears to be the most useful in the clinical practice (sensitivity 98% and specificity 90%).2) Easy to perform, cheap, the results can be obtained within 20 minutes (for instance during the night in emergency situations).

Diagnostic Value of a New Sensitive Membrane Based Technique for Instantaneous D-Dimer Evaluation in Patients with Clinically Suspected Deep Venous Thrombosis

1997 ◽  
Vol 77 (04) ◽  
pp. 637-640 ◽  
Author(s):  
Christophe Leroyer ◽  
Martine Escoffre ◽  
Emmanuelle Le Moigne ◽  
Marc Grimaux ◽  
Olivier Cagnioncle ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Predictive Value ◽  
Clinical Signs ◽  
High Sensitivity ◽  
Diagnostic Value ◽  
Lower Sensitivity ◽  
Predictive Values ◽  
Study Results ◽  
D Dimer

SummaryBackground: Plasma D-Dimer analysis, using ELISA assays, has demonstrated in previous studies a high sensitivity, suggesting its utility in excluding deep venous thrombosis (DVT). Aim: To assess the performance of a new rapid plasma D-Dimer ELISA measurement in suspected DVT patients with recent clinical signs, not exceeding one week. Methods: A prospective study of patients admitted for a suspected recent DVT. Contrast venography or compression ultrasonography were performed within 24 h of admission. A new membrane based ELISA technique, which uses an immunofiltration and two complementary monoclonal antibodies was tested. Results were expressed as positive or negative. A standard plasma D-Dimer ELISA measurement was also performed. D-Dimer performances were assessed at the end of the study. Results: 265/448 patients had a proven DVT (72 distal, 193 proximal). The sensitivity of the instantaneous method in the diagnosis of overall DVT is 92 ± 3.4% (95% Cl), and specificity is 36.6 ± 6.9%. Positive predictive value is 67.7 ± 4.8% and negative predictive value is 76.1 ± 8.9%. Sensitivity and negative predictive values reach 97.9 and 94.3% in the diagnosis of proximal DVT, but only 76.3 and 79.7% in the diagnosis of distal DVT. Similar results are observed with the standard ELISA method. Conclusion: This new rapid plasma D-Dimer measurement appears highly sensitive, and could substitute the older ELISA methods. Both methods provide lower sensitivity in the case of a distal DVT location.

Analysis of Measured D-dimer Levels for Detection of Deep Venous Thrombosis and Pulmonary Embolism After Spinal Surgery

2011 ◽  
Vol 24 (4) ◽  
pp. E35-E39 ◽  
Author(s):  
Toyomi Yoshiiwa ◽  
Masashi Miyazaki ◽  
Chikahiro Takita ◽  
Ichiro Itonaga ◽  
Hiroshi Tsumura
Keyword(s):  
Pulmonary Embolism ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Spinal Surgery ◽  
D Dimer

Diagnostic value of d -dimer in patients with a moderate pretest probability of deep venous thrombosis

2002 ◽  
Vol 118 (1) ◽  
pp. 275-277 ◽  
Author(s):  
Carlos Aguilar ◽  
Angela Martinez ◽  
Angel Martinez ◽  
Concepcion Del Rio ◽  
Mar Vazquez ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Diagnostic Value ◽  
Pretest Probability ◽  
D Dimer

D-dimer Strategy in Thrombosis Exclusion

1998 ◽  
Vol 79 (01) ◽  
pp. 32-37 ◽  
Author(s):  
H. Trillaud ◽  
S. Labrouche ◽  
P. Gauthier ◽  
S. Javorschi ◽  
P. Bernard ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Gold Standard ◽  
Quantitative Methods ◽  
Rapid Methods ◽  
Radiologic Examination ◽  
The Cost ◽  
D Dimer

SummaryDD are now recognized as a valuable tool to screen patients suspected of deep venous thrombosis or pulmonary embolism before carrying out a gold standard radiologic examination. The newest methods available claim to be able to ascertain the absence of thrombosis, but they have yet to prove their efficiency. We compared the performances of 3 reference ELISA methods (D-DI Asserachrom™ Stago, D-dimer Enzygnost™ Behring and Dimertest GOLD EIA™ Agen), 5 recent rapid methods (VIDAS D-Dimer™ bioMérieux, Instant IA™ Stago, Simplired™ Agen, Nycocard D-dimer™ Nycomed and Accuclot D-Dimer™ Sigma Diagnostics) and two routine latex methods (Dimertest™ American Diagnostica and FDP-Slidex™ bioMérieux) in 100 patients. One of the rapid quantitative methods was demonstrated to have a level of efficiency comparable to that of ELISA methods. Finally, the cost and efficiency of different strategies were evaluated, the association of a routine latex method with the VIDAS D-Dimer™ bioMérieux being proven to be the most efficient.

85 Assessment of D-dimer in plasma: Diagnostic value in suspected deep venous thrombosis of the leg

1988 ◽  
Vol 2 ◽  
pp. 39
Author(s):  
Peter Ott ◽  
Lone Astrup ◽  
Rene Hartvig Jensen ◽  
Bente Nyeland ◽  
Bo Pedersen
Keyword(s):  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Diagnostic Value ◽  
Plasma Diagnostic ◽  
D Dimer

scholarly journals Novel Biomarkers Associated with Deep Venous Thrombosis: A Comprehensive Review

2008 ◽  
Vol 3 ◽  
pp. 117727190800300 ◽  
Author(s):  
Dawn M Barnes ◽  
Thomas W Wakefield ◽  
John E Rectenwald
Keyword(s):  
Pulmonary Embolism ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Duplex Ultrasound ◽  
Interleukin 10 ◽  
Serum Marker ◽  
Specific Objective ◽  
Venous Thromboembolic ◽  
Novel Biomarkers ◽  
D Dimer

Primary and recurrent venous thromboembolic disease (VTE, deep venous thrombosis and pulmonary embolism) remain a significant source of morbidity and mortality in the hospitalized patient. Non-specific subjective complaints and lack of specific objective findings related to acute deep venous thrombosis (DVT) and pulmonary embolism (PE) complicate the diagnosis. There remains no single serum marker available to exclusively confirm the diagnosis of VTE. While D-dimer is highly sensitive and useful for diagnostic exclusion, it lacks the specificity necessary for diagnostic confirmation resulting in the need for a variety of additional studies (i.e.: duplex ultrasound, venography, V/Q scanning, helical thoracic and pelvic CT scans and pulmoary angiography). There is evolving research supporting the utility of various plasma markers as novel “biomarkers” for VTE including selectins, microparticles, interleukin-10 and other cytokines. This review attempts to examine recent literature assessing the utility of P-selectin, microparticles, D-dimer, E-selectin, thrombin, interleukins and fibrin monomers in the diagnosis and guidance of therapy for VTE.

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