Diagnostic value of d -dimer in patients with a moderate pretest probability of deep venous thrombosis

2002 ◽  
Vol 118 (1) ◽  
pp. 275-277 ◽  
Author(s):  
Carlos Aguilar ◽  
Angela Martinez ◽  
Angel Martinez ◽  
Concepcion Del Rio ◽  
Mar Vazquez ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Diagnostic Value ◽  
Pretest Probability ◽  
D Dimer

Diagnostic Value of a New Sensitive Membrane Based Technique for Instantaneous D-Dimer Evaluation in Patients with Clinically Suspected Deep Venous Thrombosis

1997 ◽  
Vol 77 (04) ◽  
pp. 637-640 ◽  
Author(s):  
Christophe Leroyer ◽  
Martine Escoffre ◽  
Emmanuelle Le Moigne ◽  
Marc Grimaux ◽  
Olivier Cagnioncle ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Predictive Value ◽  
Clinical Signs ◽  
High Sensitivity ◽  
Diagnostic Value ◽  
Lower Sensitivity ◽  
Predictive Values ◽  
Study Results ◽  
D Dimer

SummaryBackground: Plasma D-Dimer analysis, using ELISA assays, has demonstrated in previous studies a high sensitivity, suggesting its utility in excluding deep venous thrombosis (DVT). Aim: To assess the performance of a new rapid plasma D-Dimer ELISA measurement in suspected DVT patients with recent clinical signs, not exceeding one week. Methods: A prospective study of patients admitted for a suspected recent DVT. Contrast venography or compression ultrasonography were performed within 24 h of admission. A new membrane based ELISA technique, which uses an immunofiltration and two complementary monoclonal antibodies was tested. Results were expressed as positive or negative. A standard plasma D-Dimer ELISA measurement was also performed. D-Dimer performances were assessed at the end of the study. Results: 265/448 patients had a proven DVT (72 distal, 193 proximal). The sensitivity of the instantaneous method in the diagnosis of overall DVT is 92 ± 3.4% (95% Cl), and specificity is 36.6 ± 6.9%. Positive predictive value is 67.7 ± 4.8% and negative predictive value is 76.1 ± 8.9%. Sensitivity and negative predictive values reach 97.9 and 94.3% in the diagnosis of proximal DVT, but only 76.3 and 79.7% in the diagnosis of distal DVT. Similar results are observed with the standard ELISA method. Conclusion: This new rapid plasma D-Dimer measurement appears highly sensitive, and could substitute the older ELISA methods. Both methods provide lower sensitivity in the case of a distal DVT location.

85 Assessment of D-dimer in plasma: Diagnostic value in suspected deep venous thrombosis of the leg

1988 ◽  
Vol 2 ◽  
pp. 39
Author(s):  
Peter Ott ◽  
Lone Astrup ◽  
Rene Hartvig Jensen ◽  
Bente Nyeland ◽  
Bo Pedersen
Keyword(s):  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Diagnostic Value ◽  
Plasma Diagnostic ◽  
D Dimer

Assessment of D-dimer in Plasma: Diagnostic Value in Suspected Deep Venous Thrombosis of the Leg

2009 ◽  
Vol 224 (3) ◽  
pp. 263-267 ◽  
Author(s):  
PETER OTT ◽  
LONE ASTRUP ◽  
RENE HARTVIG JENSEN ◽  
BENTE NYELAND ◽  
BO PEDERSEN
Keyword(s):  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Diagnostic Value ◽  
Plasma Diagnostic ◽  
D Dimer
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