Chapter 3 Somatic Cell Genetics and the Development of the Immune System

1980 ◽  
pp. 59-96 ◽  
Author(s):  
Peter D'Eustachio ◽  
Frank H. Ruddle
Keyword(s):  
Immune System ◽  
Somatic Cell ◽  
Somatic Cell Genetics

scholarly journals Genome-Wide Associations for Microscopic Differential Somatic Cell Count and Specific Mastitis Pathogens in Holstein Cows in Compost-Bedded Pack and Cubicle Farming Systems

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1839
Author(s):  
Patricia Wagner ◽  
Tong Yin ◽  
Kerstin Brügemann ◽  
Petra Engel ◽  
Christina Weimann ◽  
...  
Keyword(s):  
Immune System ◽  
Somatic Cell ◽  
Candidate Genes ◽  
Farming Systems ◽  
Farming System ◽  
Environmental Stressors ◽  
Udder Health ◽  
Genome Wide ◽  
Cell Fractions ◽  
Mastitis Pathogens

The aim of the present study was to detect significant SNP (single-nucleotide polymorphism) effects and to annotate potential candidate genes for novel udder health traits in two different farming systems. We focused on specific mastitis pathogens and differential somatic cell fractions from 2198 udder quarters of 537 genotyped Holstein Friesian cows. The farming systems comprised compost-bedded pack and conventional cubicle barns. We developed a computer algorithm for genome-wide association studies allowing the estimation of main SNP effects plus consideration of SNPs by farming system interactions. With regard to the main effect, 35 significant SNPs were detected on 14 different chromosomes for the cell fractions and the pathogens. Six SNPs were significant for the interaction effect with the farming system for most of the udder health traits. We inferred two possible candidate genes based on significant SNP interactions. HEMK1 plays a role in the development of the immune system, depending on environmental stressors. CHL1 is regulated in relation to stress level and influences immune system mechanisms. The significant interactions indicate that gene activity can fluctuate depending on environmental stressors. Phenotypically, the prevalence of mastitis indicators differed between systems, with a notably lower prevalence of minor bacterial indicators in compost systems.

scholarly journals Guido Pontecorvo. 29 November 1907 – 25 September 1999

2002 ◽  
Vol 48 ◽  
pp. 375-390 ◽  
Author(s):  
O. Siddiqi
Keyword(s):  
Somatic Cell ◽  
Aspergillus Nidulans ◽  
Royal Society ◽  
Large Body ◽  
Somatic Cell Genetics ◽  
Parasexual Cycle ◽  
Sense Of Humor ◽  
Human Somatic Cell

Guido Pontecorvo was elected a Fellow of The Royal Society in 1955 for his contributions to the genetics of Drosophila and the fungus Aspergillus nidulans . Pontecorvo was a leading British geneticist, prominent in the decade preceding the discovery of DNA, who enriched our understanding of genes and whose pioneering work on the parasexual cycle in fungi found application in human somatic cell genetics. Known to friends as Ponte, he had a strong personality. Somewhat irascible but warm, with a wry sense of humor, he made many lifelong friends and acquired a large body of admirers.

Somatic Cell Genetics of Antibody-secreting Cells: Studies of Clonal Diversification and Analysis by Cell Fusion

1977 ◽  
Vol 41 (0) ◽  
pp. 793-803 ◽  
Author(s):  
C. Milstein ◽  
K. Adetugbo ◽  
N. J. Cowan ◽  
G. Kohler ◽  
D. S. Secher ◽  
...  
Keyword(s):  
Somatic Cell ◽  
Cell Fusion ◽  
Somatic Cell Genetics ◽  
Antibody Secreting Cells
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