Chapter 21 The old animal as a model in research on brain aging and Alzheimer's disease/senile dementia of the Alzheimer type

1986 ◽  
pp. 337-343 ◽  
Author(s):  
C.F. Hollander ◽  
J. Mos
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Aging ◽  
Senile Dementia ◽  
Alzheimer Type ◽  
Senile Dementia Of The

scholarly journals Brain Aging and Alzheimer's Disease*

1978 ◽  
Vol 23 (4) ◽  
pp. 229-233 ◽  
Author(s):  
D.R. Crapper ◽  
U. Deboni
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Immune System ◽  
Brain Aging ◽  
Senile Dementia ◽  
Pathological Process ◽  
Alzheimer Type ◽  
Neurotoxic Effect ◽  
Presenile Dementia ◽  
Common Cause

The most common cause of senile dementia appears to be a pathological process indistinguishable from that found in presenile dementia of the Alzheimer type. Consideration of the neuropathological changes suggest that this disease may involve the interaction of at least three processes: a viral-like infection, a disorder in the immune system and the neurotoxic effect of an environmental agent. The evidence in support of this hypothesis is reviewed.

Membrane Components Separate Early-Onset Alzheimer's Disease From Senile Dementia of the Alzheimer Type

1996 ◽  
Vol 8 (3) ◽  
pp. 365-372 ◽  
Author(s):  
Carl-Gerhard Gottfries ◽  
Ingvar Karlsson ◽  
Lars Svennerholm
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Brain Tissue ◽  
Membrane Lipids ◽  
Senile Dementia ◽  
Alzheimer Type ◽  
Synapse Degeneration ◽  
Membrane Components ◽  
Senile Dementia Of The

Brain tissue from 12 subjects with pure Alzheimer's disease (AD) and 21 subjects with senile dementia of the Alzheimer type (SDAT) was investigated for membrane lipids and compared with that in age-matched controls. In brain tissue from the patients with AD, phospholipids were significantly decreased compared with that from SDAT patients and controls, cholesterol was reduced compared with that in controls, and gangliosides were significantly reduced in all gray-matter areas investigated compared with those in both SDAT subjects and controls. A reduction in gangliosides also occurred in the SDAT group, but it was smaller. In the white matter, the pattern of changes was the opposite. Phospholipids, cholesterol, cerebroside, and sulfatide were significantly reduced in the frontal-lobe white matter in the SDAT group compared with that in age-matched controls and AD patients. Gangliosides in the cerebrospinal fluid also separated AD from SDAT and controls. The findings indicate synapse degeneration as an important pathogenetic factor in AD. This disorder should be separated from SDAT, in which white-matter degeneration appears to be more prominent.

An HLA and family study of Alzheimer's disease

1984 ◽  
Vol 14 (3) ◽  
pp. 515-520 ◽  
Author(s):  
E. B. Renvoize
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Family Study ◽  
Senile Dementia ◽  
Alzheimer Type ◽  
Histocompatibility Antigens ◽  
Presenile Dementia ◽  
Hla Antigen ◽  
Weak Association ◽  
Senile Dementia Of The

SynopsisHistocompatibility antigens were examined in 124 patients with Alzheimer's disease (AD), and the frequency of HLA-B15 was found to be significantly increased over controls. Pooling of data from the present and similar studies suggests that AD is not strongly associated with any particular HLA antigen, although there may be a weak association with HLA-A2, B15 and Cw3. In a family study of 34 patients with AD, secondary cases of AD were identified in 9·7% of the first-degree relatives, and cases of presenile dementia and senile dementia of the Alzheimer type were found to occur within individual families.

Sign in / Sign up

Export Citation Format

Share Document