scholarly journals LATERAL CURVATURE OF THE SPINE FOLLOWING THORACOPLASTY IN CHILDREN*

1937 ◽  
Vol 6 (6) ◽  
pp. 595-608
Author(s):  
Mather Cleveland
Keyword(s):  
Author(s):  
Hiroyuki Tsuchie ◽  
Naohisa Miyakoshi ◽  
Yuji Kasukawa ◽  
Koji Nozaka ◽  
Kimio Saito ◽  
...  

Objectives: Differences in the mechanisms of subtrochanteric and diaphyseal atypical femoral fractures (AFFs) have been speculated in studies that have analyzed differences in the patients’ backgrounds. However, the etiologies of each type of AFF have not been investigated in detail. Therefore, this study aimed to investigate the nature and etiologies of the risk factors for diaphyseal AFFs. Materials and Methods: Eighty consecutive Japanese patients with 91 diaphyseal AFFs (the AFF group) and 110 age-matched female patients with osteoporosis (the non-AFF control group) were included. Their clinical data were compared and the factors affecting AFFs were investigated. Furthermore, the etiologies of the risk factors for diaphyseal AFFs were examined. Results: Multivariate analysis revealed that femoral serrated changes, bisphosphonate or denosumab usage, and lateral and anterior femoral curvatures were the risk factors for diaphyseal AFFs (p<0.0011, p=0.0137, and p<0.0001, respectively). Multivariate analyses also revealed that serrated changes and low serum 25(OH)D levels affected the lateral curvature (p=0.0088 and 0.0205, respectively), while serrated changes affected the anterior curvature (p=0.0006); each significantly affected the femoral curvature. In addition, a high serum calcium (Ca) level, lateral femoral curvature, and anterior femoral curvature were the predictors of serrated changes (p=0.0146, 0.0002, and 0.0098, respectively). Conclusion: The risk factors for diaphyseal AFFs were bone resorption inhibitor usage, a strong femoral curvature, and serrated changes. A low serum 25(OH)D level and serrated changes are the risk factors for lateral curvature, while a high serum Ca level is a risk factor for serrated changes.


1904 ◽  
Vol 151 (18) ◽  
pp. 479-481
Author(s):  
EDWARD H. BRADFORD
Keyword(s):  

Author(s):  
Po-Jen Cheng ◽  
Kuo-Chi Liu

The paper investigates the stability theory of a thin power law liquid film flowing down along the outside surface of a vertical cylinder. The long-wave perturbation method is employed to solve for generalized linear kinematic equations with free film interface. The normal mode approach is used to compute the stability solution for the film flow. The degree of instability in the film flow is further intensified by the lateral curvature of cylinder. This is somewhat different from that of the planar flow. The analysis results also indicate that by increasing the flow index and increasing the radius of the cylinder the film flow can become relatively more stable as traveling down along the vertical cylinder.


Author(s):  
Kohei Murakami ◽  
Shingo Kikugawa ◽  
Shoji Seki ◽  
Hidetomi Terai ◽  
Takako Suzuki ◽  
...  

AbstractCongenital scoliosis (CS) is a lateral curvature of the spine characterized by the presence of vertebral anomalies. Pathogenic genetic variants in the TBX6 gene are one of the causes of CS. However, since many clinically diagnosed cases of CS are without known TBX6 gene variations, this study aims to uncover new genes related to disease susceptibility of CS by exome sequencing (ES). This study employed ES in a cohort of 5 Japanese patients with CS and their healthy parents or a sister for a total of 16 samples among 5 families. Variant interpretation was performed using SIFT, PolyPhen-2, Mutation Taster, and CADD. Four de novo variants were identified by ES and confirmed by Sanger sequencing: 1 frameshift variant (SHISA3) and 3 missense variants (AGBL5, HDAC4, and PDE2A). ES also uncovered 1 homozygous variant in the MOCOS gene. All of these variants were predicted to be deleterious by SIFT, PolyPhen-2, Mutation Taster, and/or CADD. The number of de novo variants identified in this study was exactly what would be expected by chance. Additional functional studies or gathering matched patients using Gene Matcher are needed.


2020 ◽  
Vol 38 (1) ◽  
Author(s):  
Atsuo Iida ◽  
Risako Nakai ◽  
Jumpei Nomura ◽  
Rieko Tanaka ◽  
Nobutoshi Mizuno ◽  
...  

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