Cancer in siblings of children with cancer in the Nordic countries: a population-based cohort study

The Lancet ◽  
2001 ◽  
Vol 358 (9283) ◽  
pp. 711-717 ◽  
Author(s):  
Jeanette Falck Winther ◽  
Risto Sankila ◽  
John D Boice ◽  
Hrafn Tulinius ◽  
Andrea Bautz ◽  
...  
2020 ◽  
Vol 4 (5) ◽  
Author(s):  
Lasse Wegener Lund ◽  
Jeanette Falck Winther ◽  
Luise Cederkvist ◽  
Catherine Rechnitzer ◽  
Susanne Oksbjerg Dalton ◽  
...  

Abstract Siblings of children with cancer experience severe stress early in life. Most studies of mental health problems in these siblings are limited by being small, cross-sectional, or self-reporting. In a population-based cohort study, we investigated the risk for antidepressant use by linking several nationwide, population-based registries comparing 6644 siblings of children diagnosed with cancer from 1991-2009 with 128 436 population-based sibling comparisons using the Cox proportional hazards model. Irrespective of cancer type, no increased risk of antidepressant use in siblings of children with cancer was found (hazard ratio = 1.00, 95% confidence interval = 0.91 to 1.11). However, data suggested that siblings being young at cancer diagnosis had an increased risk (2-sided Ptrend = .01). Interaction analyses showed no modifying effect of parental socioeconomic position or antidepressant use. Findings from this study with a very low risk of bias are reassuring and important for families facing childhood cancer and for clinicians counseling these families.


2014 ◽  
Vol 133 (3) ◽  
pp. 340-344 ◽  
Author(s):  
Alex J. Walker ◽  
Matthew J. Grainge ◽  
Tim R. Card ◽  
Joe West ◽  
Susanna Ranta ◽  
...  

1991 ◽  
Vol 80 (12) ◽  
pp. 1220-1228 ◽  
Author(s):  
R. NYGAARD ◽  
S. GARWICZ ◽  
T. HALDORSEN ◽  
H. HERTZ ◽  
G. K. JONMUNDSSON ◽  
...  

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