Antimicrobial resistance in the respiratory microbiota of people with cystic fibrosis

The Lancet ◽  
2014 ◽  
Vol 384 (9944) ◽  
pp. 703-713 ◽  
Author(s):  
Laura J Sherrard ◽  
Michael M Tunney ◽  
J Stuart Elborn
Keyword(s):  
Cystic Fibrosis ◽  
Antimicrobial Resistance ◽  
Respiratory Microbiota

Antimicrobial resistance in cystic fibrosis: A Delphi approach to defining best practices

2020 ◽  
Vol 19 (3) ◽  
pp. 370-375 ◽  
Author(s):  
Edith Zemanick ◽  
Pierre–Régis Burgel ◽  
Giovanni Taccetti ◽  
Alison Holmes ◽  
Felix Ratjen ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Antimicrobial Resistance ◽  
Best Practices ◽  
Delphi Approach

scholarly journals Systems Biology and Bile Acid Signalling in Microbiome-Host Interactions in the Cystic Fibrosis Lung

Antibiotics ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 766
Author(s):  
David F. Woods ◽  
Stephanie Flynn ◽  
Jose A. Caparrós-Martín ◽  
Stephen M. Stick ◽  
F. Jerry Reen ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Bile Acids ◽  
Host Response ◽  
Signal Molecules ◽  
Therapeutic Approaches ◽  
Related Factors ◽  
Host Interactions ◽  
Important Host ◽  
Respiratory Microbiota

The study of the respiratory microbiota has revealed that the lungs of healthy and diseased individuals harbour distinct microbial communities. Imbalances in these communities can contribute to the pathogenesis of lung disease. How these imbalances occur and establish is largely unknown. This review is focused on the genetically inherited condition of Cystic Fibrosis (CF). Understanding the microbial and host-related factors that govern the establishment of chronic CF lung inflammation and pathogen colonisation is essential. Specifically, dissecting the interplay in the inflammation–pathogen–host axis. Bile acids are important host derived and microbially modified signal molecules that have been detected in CF lungs. These bile acids are associated with inflammation and restructuring of the lung microbiota linked to chronicity. This community remodelling involves a switch in the lung microbiota from a high biodiversity/low pathogen state to a low biodiversity/pathogen-dominated state. Bile acids are particularly associated with the dominance of Proteobacterial pathogens. The ability of bile acids to impact directly on both the lung microbiota and the host response offers a unifying principle underpinning the pathogenesis of CF. The modulating role of bile acids in lung microbiota dysbiosis and inflammation could offer new potential targets for designing innovative therapeutic approaches for respiratory disease.

scholarly journals A Decade of Antimicrobial Resistance of Staphylococcus aureus (SA) in Cystic Fibrosis (CF): A Widespread Problem!

2016 ◽  
Vol 3 (suppl_1) ◽  
Author(s):  
Claudia Vicetti Miguel ◽  
Asuncion Mejias ◽  
Amy Leber ◽  
Pablo J. Sanchez
Keyword(s):  
Cystic Fibrosis ◽  
Staphylococcus Aureus ◽  
Antimicrobial Resistance

scholarly journals WS1.3 Respiratory microbiota dynamics in newborns with cystic fibrosis and healthy controls: A longitudinal study

2013 ◽  
Vol 12 ◽  
pp. S1
Author(s):  
S.M.P.J. Prevaes ◽  
K.M. de Winter-de Groot ◽  
G.A. Tramper-Stranders ◽  
H.A.W.M. Tiddens ◽  
M. van Westreenen ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Longitudinal Study ◽  
Healthy Controls ◽  
Respiratory Microbiota

scholarly journals 84 Respiratory microbiota in children with cystic fibrosis and healthy controls

2014 ◽  
Vol 13 ◽  
pp. S67
Author(s):  
C.W. Holmes ◽  
D.W. Rivett ◽  
D.E. Modha ◽  
K.D. Bruce ◽  
E.A. Gaillard
Keyword(s):  
Cystic Fibrosis ◽  
Healthy Controls ◽  
Respiratory Microbiota

scholarly journals Genomic Diversity and Antimicrobial Resistance of Haemophilus Colonizing the Airways of Young Children with Cystic Fibrosis

mSystems ◽  
2021 ◽  
Vol 6 (4) ◽  
Author(s):  
Stephen C. Watts ◽  
Louise M. Judd ◽  
Rosemary Carzino ◽  
Sarath Ranganathan ◽  
Kathryn E. Holt
Keyword(s):  
Cystic Fibrosis ◽  
Antimicrobial Resistance ◽  
Young Children ◽  
Lung Disease ◽  
Respiratory Infections ◽  
Genomic Diversity ◽  
Disease Development ◽  
Acute Respiratory Infections ◽  
Early Disease ◽  
Advanced Stages

Cystic fibrosis (CF) lung disease begins during infancy, and acute respiratory infections increase the risk of early disease development and progression. Microbes involved in advanced stages of CF are well characterized, but less is known about early respiratory colonizers.

scholarly journals Multidimensional Clinical Surveillance of Pseudomonas aeruginosa Reveals Complex Relationships between Isolate Source, Morphology, and Antimicrobial Resistance

mSphere ◽  
2021 ◽  
Author(s):  
Laura J. Dunphy ◽  
Glynis L. Kolling ◽  
Matthew L. Jenior ◽  
Joanne Carroll ◽  
April E. Attai ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Antimicrobial Resistance ◽  
Nosocomial Infection ◽  
Clinical Setting ◽  
Content Type ◽  
Pathogen Virulence ◽  
Clinical Surveillance ◽  
Complex Relationships

P. aeruginosa is a leading cause of nosocomial infection and infection in patients with cystic fibrosis. While P. aeruginosa infection and treatment can be complicated by a variety of antimicrobial resistance and virulence mechanisms, pathogen virulence is rarely recorded in a clinical setting.

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