LOW-DOSE ORAL PROPRANOLOL

Hemangiomas, are the most common benign tumors of infancy. Despite their selflimited course, infantile capillary hemangiomas can cause local complications e.g. pain, ulceration, bleeding etc. The usual treatments include oral/intralesional steroids, alpha interferon, cytotoxins, pulsed dye laser and cosmetic surgery resection. These treatments are not free of multiple complications and toxic side effects. We report our experience with the use of propranolol in 2 children with haemangiomas along with review of relevant literature. Both the hemangioma cases promptly responded to low-dose oral propranolol. DOI: http://dx.doi.org/10.3329/bmjk.v47i1-2.22561 Bang Med J (Khulna) 2014; 47 : 32-35

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LOW-DOSE ORAL PROPRANOLOL

The Lancet ◽

10.1016/s0140-6736(78)90825-5 ◽

1978 ◽

Vol 311 (8066) ◽

pp. 715

Author(s):

C.F. George

Keyword(s):

Low Dose ◽

Dose Oral ◽

Oral Propranolol

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Periocular capillary hemangioma treated with low dose oral propranolol - presentation and outcome of 30 patients

Archives of Pathology and Clinical Research ◽

10.29328/journal.apcr.1001027 ◽

2021 ◽

Vol 5 (1) ◽

pp. 037-041

Author(s):

Roy Soma Rani ◽

Nuruddin Murtuza

Keyword(s):

Low Dose ◽

Color Change ◽

Initial Response ◽

Capillary Hemangioma ◽

Response To Treatment ◽

P Value ◽

Outpatient Basis ◽

Cost Effective Treatment ◽

Dose Oral ◽

Oral Propranolol

Purpose: To evaluate the presentation and outcome of periocular capillary hemangioma treated with low-dose oral propranolol. Method: Thirty cases of periocular capillary hemangioma prospectively studied from 1st June 2015 to 31st May 2017 who received oral propranolol on an outpatient basis. Hemangioma causing any threat to vision or disfigurement was included and age below 3 months and multiple lesions were excluded. Starting dose of propranolol was 1 mg/kg and increased to 2 mg/kg after 2 weeks as a maintenance dose. The tapering dose was 1 mg/kg of body weight before discontinuing the medication. Treatment was continued till the child is 1 year of age or no further change in color or size of the lesion in two successive follow-ups. Results: Presenting age was 6.36 ± 3.36 months (ranged 3–24 months) with female predominance (70%). In 86.6% of cases, the vision was Central Steady and Maintained and cycloplegic refraction showed marked astigmatism in 3 children which resolved after treatment. Forty-six percent of children showed color change as an initial response to treatment. Most children (33.3%) responded completely within 5 months after starting the treatment. One third patients (33.3%) showed 100% resolution, 50% showed 90% to 70% resolution. Pretreatment and post-treatment lesion size was1.60 ± 0.86 cm2 and 0.30 ± 0.40 cm2 respectively (p - value < 0.0005). None showed any significant adverse effect of oral propranolol. Conclusion: Low-dose oral propranolol is an effective and cost-effective treatment modality for periocular capillary hemangioma and is safe as an outpatient basis.

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