scholarly journals Periocular capillary hemangioma treated with low dose oral propranolol - presentation and outcome of 30 patients

2021 ◽  
Vol 5 (1) ◽  
pp. 037-041
Author(s):  
Roy Soma Rani ◽  
Nuruddin Murtuza
Keyword(s):  
Low Dose ◽  
Color Change ◽  
Initial Response ◽  
Capillary Hemangioma ◽  
Response To Treatment ◽  
P Value ◽  
Outpatient Basis ◽  
Cost Effective Treatment ◽  
Dose Oral ◽  
Oral Propranolol

Purpose: To evaluate the presentation and outcome of periocular capillary hemangioma treated with low-dose oral propranolol. Method: Thirty cases of periocular capillary hemangioma prospectively studied from 1st June 2015 to 31st May 2017 who received oral propranolol on an outpatient basis. Hemangioma causing any threat to vision or disfigurement was included and age below 3 months and multiple lesions were excluded. Starting dose of propranolol was 1 mg/kg and increased to 2 mg/kg after 2 weeks as a maintenance dose. The tapering dose was 1 mg/kg of body weight before discontinuing the medication. Treatment was continued till the child is 1 year of age or no further change in color or size of the lesion in two successive follow-ups. Results: Presenting age was 6.36 ± 3.36 months (ranged 3–24 months) with female predominance (70%). In 86.6% of cases, the vision was Central Steady and Maintained and cycloplegic refraction showed marked astigmatism in 3 children which resolved after treatment. Forty-six percent of children showed color change as an initial response to treatment. Most children (33.3%) responded completely within 5 months after starting the treatment. One third patients (33.3%) showed 100% resolution, 50% showed 90% to 70% resolution. Pretreatment and post-treatment lesion size was1.60 ± 0.86 cm2 and 0.30 ± 0.40 cm2 respectively (p - value < 0.0005). None showed any significant adverse effect of oral propranolol. Conclusion: Low-dose oral propranolol is an effective and cost-effective treatment modality for periocular capillary hemangioma and is safe as an outpatient basis.

scholarly journals Efficacy of propranolol in infantile hemangioma

2015 ◽  
Vol 47 (1-2) ◽  
pp. 32-35
Author(s):  
Mizanur Rahman ◽  
Md Tarikul Islam ◽  
Ratan Lal Dutta Banik ◽  
Choudhury Habibur Rasul
Keyword(s):  
Side Effects ◽  
Cosmetic Surgery ◽  
Low Dose ◽  
Relevant Literature ◽  
Infantile Hemangioma ◽  
Benign Tumors ◽  
Dose Oral ◽  
Oral Propranolol ◽  
Intralesional Steroids ◽  
Surgery Resection

Hemangiomas, are the most common benign tumors of infancy. Despite their selflimited course, infantile capillary hemangiomas can cause local complications e.g. pain, ulceration, bleeding etc. The usual treatments include oral/intralesional steroids, alpha interferon, cytotoxins, pulsed dye laser and cosmetic surgery resection. These treatments are not free of multiple complications and toxic side effects. We report our experience with the use of propranolol in 2 children with haemangiomas along with review of relevant literature. Both the hemangioma cases promptly responded to low-dose oral propranolol. DOI: http://dx.doi.org/10.3329/bmjk.v47i1-2.22561 Bang Med J (Khulna) 2014; 47 : 32-35

LOW-DOSE ORAL PROPRANOLOL

The Lancet ◽  
1978 ◽  
Vol 311 (8066) ◽  
pp. 715
Author(s):  
C.F. George
Keyword(s):  
Low Dose ◽  
Dose Oral ◽  
Oral Propranolol

LOW-DOSE ORAL PROPRANOLOL

The Lancet ◽  
1978 ◽  
Vol 311 (8069) ◽  
pp. 882
Author(s):  
N.S Baber ◽  
J Mcainsh
Keyword(s):  
Low Dose ◽  
Dose Oral ◽  
Oral Propranolol

β-Adrenoreceptor Blockade and Blood Levels following Short-Term Very Low-Dose Oral Propranolol

1978 ◽  
Vol 54 (2) ◽  
pp. 7P-7P
Author(s):  
R. Davies ◽  
T. Pickering ◽  
A. Morganti ◽  
G. Bianchetti ◽  
P. Morselli ◽  
...  
Keyword(s):  
Low Dose ◽  
Blood Levels ◽  
Short Term ◽  
Dose Oral ◽  
Oral Propranolol

LOW-DOSE ORAL PROPRANOLOL

The Lancet ◽  
1978 ◽  
Vol 311 (8068) ◽  
pp. 827-828
Author(s):  
Roy Davies ◽  
T.G. Pickering ◽  
A. Morganti ◽  
G. Bianchetti ◽  
P.L. Morselli ◽  
...  
Keyword(s):  
Low Dose ◽  
Dose Oral ◽  
Oral Propranolol

LOW-DOSE ORAL PROPRANOLOL

The Lancet ◽  
1978 ◽  
Vol 312 (8086) ◽  
pp. 425 ◽  
Author(s):  
LucP. Balant ◽  
Jean Fabre
Keyword(s):  
Low Dose ◽  
Dose Oral ◽  
Oral Propranolol

scholarly journals Treatment of Plane Warts with a Low-Dose Oral Isotretinoin

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Hayder R. Al-Hamamy ◽  
Husam Ali Salman ◽  
Nawar A. Abdulsattar
Keyword(s):  
Treatment Period ◽  
Relapse Rate ◽  
Cumulative Dose ◽  
Low Dose ◽  
Complete Response ◽  
Response To Treatment ◽  
Dose Oral ◽  
Oral Isotretinoin ◽  
The Difference ◽  
Facial Plane

Objective. To assess the efficacy of a low-dose oral isotretinoin in the treatment of plane warts. Patients and Methods. Thirty-one patients with recalcitrant facial plane warts were enrolled. A cumulative dose of 30 mg/kg for two months of treatment was calculated; this was equal to a mean of 0.5 mg/kg/day. Each patient was seen every two weeks during the treatment period. Response to treatment was either complete or no response. Patients with complete response were followed up monthly for four months to record the relapse rate. Results. Twenty-six patients completed the study; their ages range from 5 to 35 with a mean ± SD years. Fifteen (57.69%) patients were females and eleven (42.30%) were males. Nineteen (73.07%) patients showed complete response and seven (26.92%) patients showed no response at the end of two months of therapy. The difference was statistically significant; P value . Fifteen (78.94%) out of nineteen patients, who had complete response, were still free from warts at the end of four-month followup. Conclusion. Oral isotretinoin is effective in the treatment of recalcitrant facial plane warts.

Low-Dose Oral Propranolol Could Reduce Brown Adipose Tissue F-18 FDG Uptake in Patients Undergoing PET Scans

2007 ◽  
Vol 32 (5) ◽  
pp. 351-357 ◽  
Author(s):  
Oscar Parysow ◽  
Ana M. Mollerach ◽  
Victor Jager ◽  
Silvina Racioppi ◽  
Jose San Roman ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Low Dose ◽  
Fdg Uptake ◽  
Brown Adipose ◽  
Dose Oral ◽  
Pet Scans ◽  
Oral Propranolol

scholarly journals Infliximab Salvage Therapy after Cyclosporine in an Acute Flare of Chronic Ulcerative Colitis

2003 ◽  
Vol 17 (3) ◽  
pp. 198-200 ◽  
Author(s):  
ECS Lam ◽  
RJ Bailey
Keyword(s):  
Ulcerative Colitis ◽  
Continuous Infusion ◽  
Chronic Ulcerative Colitis ◽  
Salvage Therapy ◽  
Low Dose ◽  
Initial Response ◽  
Dose Oral ◽  
History Of ◽  
Intravenous Steroids ◽  
Steroid Refractory

Although infliximab (Remicade, Schering Canada Inc, Quebec) therapy has been well studied in steroid refractory Crohn’s disease, its use remains controversial in chronic ulcerative colitis. A 24-year-old woman with a 14-year history of well controlled left sided ulcerative colitis presented with an acute flare. Clinical, endoscopic and biopsy evidence of an acute flare of ulcerative pancolitis were present. There was no response to intravenous steroids but improvement was seen after receiving 14 days of intravenous cyclosporine (4 mg/kg/day continuous infusion). The patient was discharged from hospital with azathioprine (2.5 mg/kg/day) and low dose oral cyclosporine (4 mg/kg/day). She presented with worsening symptoms seven days after discharge. Because of the patient’s unwillingness for surgery, she instead received two injections of infliximab 5 mg/kg at week 0 and week 2. An initial response occurred, but her clinical improvement was not durable. Colectomy was performed four weeks later. This is the first report of infliximab as a salvage therapy in an acute flare of chronic ulcerative colitis following failure of cyclosporine.

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