β-Adrenoreceptor Blockade and Blood Levels following Short-Term Very Low-Dose Oral Propranolol

1978 ◽  
Vol 54 (2) ◽  
pp. 7P-7P
Author(s):  
R. Davies ◽  
T. Pickering ◽  
A. Morganti ◽  
G. Bianchetti ◽  
P. Morselli ◽  
...  
Keyword(s):  
Low Dose ◽  
Blood Levels ◽  
Short Term ◽  
Dose Oral ◽  
Oral Propranolol

BETA-BLOCKADE AND BLOOD-LEVELS AFTER LOW-DOSE ORAL PROPRANOLOL: THE HEPATIC "FIRST-PASS" THRESHOLD REVISITED

The Lancet ◽  
1978 ◽  
Vol 311 (8061) ◽  
pp. 407-410 ◽  
Author(s):  
Roy Davies ◽  
Alberto Morganti ◽  
PauloL. Morselli ◽  
ThomasG. Pickering ◽  
Gabrio Bianchetti ◽  
...  
Keyword(s):  
Low Dose ◽  
Beta Blockade ◽  
Blood Levels ◽  
First Pass ◽  
Dose Oral ◽  
Oral Propranolol

scholarly journals Efficacy of propranolol in infantile hemangioma

2015 ◽  
Vol 47 (1-2) ◽  
pp. 32-35
Author(s):  
Mizanur Rahman ◽  
Md Tarikul Islam ◽  
Ratan Lal Dutta Banik ◽  
Choudhury Habibur Rasul
Keyword(s):  
Side Effects ◽  
Cosmetic Surgery ◽  
Low Dose ◽  
Relevant Literature ◽  
Infantile Hemangioma ◽  
Benign Tumors ◽  
Dose Oral ◽  
Oral Propranolol ◽  
Intralesional Steroids ◽  
Surgery Resection

Hemangiomas, are the most common benign tumors of infancy. Despite their selflimited course, infantile capillary hemangiomas can cause local complications e.g. pain, ulceration, bleeding etc. The usual treatments include oral/intralesional steroids, alpha interferon, cytotoxins, pulsed dye laser and cosmetic surgery resection. These treatments are not free of multiple complications and toxic side effects. We report our experience with the use of propranolol in 2 children with haemangiomas along with review of relevant literature. Both the hemangioma cases promptly responded to low-dose oral propranolol. DOI: http://dx.doi.org/10.3329/bmjk.v47i1-2.22561 Bang Med J (Khulna) 2014; 47 : 32-35

Neuroimmunological Effects of Exposure to Methylmercury Forms in the Sprague-Dawley Rats. Activation of the Hypothalamic-Pituitary-Adrenal Axis and Lymphocyte Responsiveness

1997 ◽  
Vol 13 (1) ◽  
pp. 57-66 ◽  
Author(s):  
Hector G. Ortega ◽  
Manuel Lopez ◽  
Atsushi Takaki ◽  
Qin-Heng Huang ◽  
Akira Arimura ◽  
...  
Keyword(s):  
Hpa Axis ◽  
Low Dose ◽  
Fold Increase ◽  
Exposed Group ◽  
Blood Levels ◽  
High Dose ◽  
Sprague Dawley ◽  
Short Term ◽  
Hypothalamic Pituitary Adrenal ◽  
Short Term Exposure

The effects of different methylmercury (MeHg) forms on the immune system and the hypothalamic pituitary adrenal (HPA) axis were assessed. The lymphocyte response to Concanavalin A (Con A) stimulation, blood levels of interleukin-6 (IL-6), adrenocorticotrophin hormone (ACTH), and corticosterone in the presence of different MeHg compounds was measured. Rats were exposed to methylmercury sulfide [(MeHg)2S] and methylmercury chloride (MeHgCl) at concentrations of 5 and 500 μg per liter in the drinking water for 8 or 16 weeks. Short-term exposure (8 weeks) at both, low- and high-doses of (MeHg)2S significantly enhanced lymphocyte responsiveness. MeHgCl only induced increased lymphocyte responsiveness at the low-dose exposure. Circulating levels of IL-6 after short-term exposure were increased in the MeHgCl-exposed group. The HPA axis activation was demonstrated by increased levels of ACTH and corticosterone levels. This response was predominant in low-dose exposed animals. Long-term (16 weeks) exposure resulted in a reduction in lymphocyte proliferation after both low- and high-dose MeHgCl exposures. The (MeHg)2S exposure resulted in a 3-fold increase in the proliferative response. Levels of ACTH were elevated 3-fold in the (MeHg)2S-exposed group, and no increase of corticosterone was observed in the high-dose exposed group at 8 weeks, no effect of(MeHg)2S was observed at 16 weeks. The MeHgCl exposed group showed an increase in ACTH and corticosterone levels at 8 weeks; this response was not observed at 16 weeks. These data indicate that exposure to MeHg compounds enhances T-cell proliferation in most of the cases, in a dose- and time-dependent fashion. Release of IL-6 also depends on the length of exposure. Early increases in circulating ACTH at 8 weeks also suggest activation of the HPA axis. This may contribute to the production of IL-6 and surveillance of regulatory homeostatic responses against environmental agents that mimic stress-like responses.

LOW-DOSE ORAL PROPRANOLOL

The Lancet ◽  
1978 ◽  
Vol 311 (8066) ◽  
pp. 715
Author(s):  
C.F. George
Keyword(s):  
Low Dose ◽  
Dose Oral ◽  
Oral Propranolol

scholarly journals Periocular capillary hemangioma treated with low dose oral propranolol - presentation and outcome of 30 patients

2021 ◽  
Vol 5 (1) ◽  
pp. 037-041
Author(s):  
Roy Soma Rani ◽  
Nuruddin Murtuza
Keyword(s):  
Low Dose ◽  
Color Change ◽  
Initial Response ◽  
Capillary Hemangioma ◽  
Response To Treatment ◽  
P Value ◽  
Outpatient Basis ◽  
Cost Effective Treatment ◽  
Dose Oral ◽  
Oral Propranolol

Purpose: To evaluate the presentation and outcome of periocular capillary hemangioma treated with low-dose oral propranolol. Method: Thirty cases of periocular capillary hemangioma prospectively studied from 1st June 2015 to 31st May 2017 who received oral propranolol on an outpatient basis. Hemangioma causing any threat to vision or disfigurement was included and age below 3 months and multiple lesions were excluded. Starting dose of propranolol was 1 mg/kg and increased to 2 mg/kg after 2 weeks as a maintenance dose. The tapering dose was 1 mg/kg of body weight before discontinuing the medication. Treatment was continued till the child is 1 year of age or no further change in color or size of the lesion in two successive follow-ups. Results: Presenting age was 6.36 ± 3.36 months (ranged 3–24 months) with female predominance (70%). In 86.6% of cases, the vision was Central Steady and Maintained and cycloplegic refraction showed marked astigmatism in 3 children which resolved after treatment. Forty-six percent of children showed color change as an initial response to treatment. Most children (33.3%) responded completely within 5 months after starting the treatment. One third patients (33.3%) showed 100% resolution, 50% showed 90% to 70% resolution. Pretreatment and post-treatment lesion size was1.60 ± 0.86 cm2 and 0.30 ± 0.40 cm2 respectively (p - value < 0.0005). None showed any significant adverse effect of oral propranolol. Conclusion: Low-dose oral propranolol is an effective and cost-effective treatment modality for periocular capillary hemangioma and is safe as an outpatient basis.

scholarly journals Short-term Low-dose Oral Corticosteroid Therapy of Impingement Syndrome of the Shoulder: A Comparison of the Clinical Outcomes to Intra-articular Corticosteroid Injection

2014 ◽  
Vol 17 (2) ◽  
pp. 50-56
Author(s):  
Young Bok Kim ◽  
Young Chang Kim ◽  
Ji Wan Kim ◽  
Sang Jin Lee ◽  
Sang Won Lee ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Corticosteroid Therapy ◽  
Low Dose ◽  
Oral Corticosteroid ◽  
Impingement Syndrome ◽  
Oral Steroid ◽  
Short Term ◽  
Dose Oral ◽  
Ucla Score ◽  
Oral Corticosteroid Therapy

BACKGROUND: To assess the clinical outcomes of short-term oral corticosteroid therapy for impingement syndrome of the shoulder and determine whether it can be substituted as an alternative to the intra-articular injection.METHODS: The clinical outcomes of the 173 patients, the oral steroid group (n=88) and the injection group (n=85), were measured at 3 weeks, 2, 4, and 6 months postoperatively. The clinical outcomes were assessed by measuring the the University of California at Los Angeles (UCLA) score, visual analog scale (VAS) and range of motion (ROM) at every follow-up. Any complications and recurrence rate were noted. A relationship between the treatment outcomes and factors such as demographic factors, clinical symptoms and radiographic findings were determined.RESULTS: No difference was observed in VAS and UCLA scores between the two groups, but forward flexion and internal rotation of ROM were significantly improved in the injection group at the 2nd and 4th postoperative month (p < 0.05). At 6th postoperative month, recurrence rate of symptoms was 26% in the oral steroid group and 22% in the injection group. No major adverse effects were observed. When the clinical outcomes of the oral steroid group were compared to either demographic, clinical symptoms, or radiographic findings, UCLA score was found to be significantly low (p < 0.05) in patients with joint stiffness and UCLA score, whereas VAS score was significantly improved in patients with night pain (p < 0.05).CONCLUSIONS: Short-term low-dose oral corticosteroid therapy of impingement syndrome showed comparable clinical outcomes to intra-articular injection without any remarkable adverse effects. Low-dose oral steroids can be regarded as a partial alternative to intra-articular injection for the initial therapy of impingement syndrome of the shoulder.

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