Pemphigus Vegetans of Neumann Type on Lip: A Case Report

: Pemphigus is a chronic autoimmune vesiculobullous disease caused by autoantibodies directed against desmogleins (Dsgs). Pemphigus vegetans is a rare variant of pemphigus vulgaris, characterized by vegetative plaques, primarily occurring in flexures. It is a less common disease and involves the skin and mucosa due to disintegration of cellular adherence (acantholysis), resulting in intradermal split. We report this case of pemphigus vegetans of Neumann type for its rare presentation. We report a case of pemphigus vegetans, involving lips in a middle-aged female and sparing flexural areas. This patient was diagnosed on the basis of histopathology and treated successfully with intralesional steroids, resulting in the resolution of her plaques.

Evaluation of age, gender, prenatal characteristics, and treatment results of 380 babies with infantile hemangioma.

e22018 Background: Infantile hemangiomas' incidence is 5% & are locally proliferated vascular structures. Methods: Fourhundred cases were analyzed,380 are presented. Results: Majority pts dx between 0-3 mos(88.8%), females (64.5 %), 26.6% had preterm birth,21.8% lbw 2500g. Maternal characteristics 17.1% were > age35, 8.5% multipar, 61.5% multiple gestation. Placental anomaly in 5.5%, preeclampsia in 10.3%, gestational diabetes in 7%, intervention in pregnancy 4.9%, smoking 7.6%, hyperemesis 29.9%. Treatment modality was topical timolol drops in 41.9%, oral propranolol solution in 37.6%, wait&see group 13.5%,surgical excision in 5.6%. Conclusions: Hemangioma, a multifactorial disease, lbw is an important risk factor.Oral propranolol solution for the babies <1yr of age avoided the use of intralesional steroids. It is essential to treat the babies especially who have the risk of developing amblyopia or other functional/cosmetic sequelae.

Clinical Profile of Melkersson-Rosenthal Syndrome/Orofacial Granulomatosis: A Review of 51 Patients

Background Melkersson–Rosenthal syndrome (MRS) is a rare disease characterized by the triad of granulomatous cheilitis, fissured tongue, and facial paralysis. Publications concerning large series are rare in the literature. Objectives To describe the clinical and histopathological characteristics of patients with complete and oligosymptomatic forms of MRS. Methods A retrospective records review was performed for the diagnoses of Melkersson-Rosenthal syndrome, granulomatous cheilitis, and orofacial granulomatosis at oral Diseases Clinic of the Department of Dermatology, University of São Paulo, Brazil (2003, 2017). Results A total of 51 patients were included, mean age at presentation 35.69 years. Four patients were younger than 18 years. The complete triad of was observed in 10 patients. The rare findings of granulomatous blepharitis, gingivitis and palatitis are presented. Comorbidities included Crohn’s disease (5 patients), migraine headaches (1 patient) and convulsions (2 patients). Granulomatous inflammatory infiltrate was detected in 31 biopsies. Medical therapies included included oral and intralesional steroids, thalidomide, dapsone, azathioprine, tetracycline, methotrexate, and surgery, with variable responses. Conclusions Our report meant to draw attention to the clinical spectrum of this rare disorder, mainly to oligosymptomatic forms and rarer presentations.

Woringer-Kolopp Disease of the Foot: A Case Report

Woringer-Kolopp disease is a rare variant of mycosis fungoides, a type of cutaneous T-cell lymphoma. Described is a case of a small annular plaque on the foot diagnosed histologically as Woringer-Kolopp disease and treated successfully with topical and intralesional steroids. In addition, a brief review of the literature and treatment options is provided.