DOUBLE-BLIND CONTROLLED TRIAL OF SINGLE-DOSE TREATMENT WITH BOVINE SURFACTANT IN SEVERE HYALINE MEMBRANE DISEASE

The Lancet ◽  
1987 ◽  
Vol 329 (8534) ◽  
pp. 651-656 ◽  
Author(s):  
TonseN.K Raju ◽  
Rama Bhat ◽  
KristineM Mcculloch ◽  
Haruo Maeta ◽  
Dharmapuri Vidyasagar ◽  
...  
Keyword(s):  
Single Dose ◽  
Controlled Trial ◽  
Hyaline Membrane Disease ◽  
Double Blind ◽  
Dose Treatment ◽  
Hyaline Membrane ◽  
Single Dose Treatment

scholarly journals Single-dose treatment of cholera with furazolidone or tetracycline in a double-blind randomized trial.

1989 ◽  
Vol 33 (9) ◽  
pp. 1447-1450 ◽  
Author(s):  
G H Rabbani ◽  
M R Islam ◽  
T Butler ◽  
M Shahrier ◽  
K Alam
Keyword(s):  
Single Dose ◽  
Randomized Trial ◽  
Double Blind ◽  
Dose Treatment ◽  
Single Dose Treatment

Double-Blind Clinical Trial of Calf Lung Surfactant Extract for the Prevention of Hyaline Membrane Disease in Extremely Premature Infants

PEDIATRICS ◽  
1985 ◽  
Vol 76 (4) ◽  
pp. 585-592 ◽  
Author(s):  
Melinda S. Kwong ◽  
Edmund A. Egan ◽  
Robert H. Notter ◽  
Donald L. Shapiro
Keyword(s):  
Premature Infants ◽  
Controlled Trial ◽  
Lung Surfactant ◽  
Hyaline Membrane Disease ◽  
Treated Group ◽  
Efficiency Index ◽  
Lung Lavage ◽  
Exogenous Surfactant ◽  
Double Blind ◽  
Hyaline Membrane

A prospective, double-blind, controlled trial was conducted to determine whether instillation of an exogenous surfactant into the lungs before the first breath could prevent hyaline membrane disease. The surfactant is calf lung lipid extracted from saline lung lavage. Entry was limited to infants who were 24 to 28 weeks' gestation, who were born at Children's Hospital of Buffalo, and whose mothers had not received betamethasone for more than 24 hours before birth. Treated infants received 3 mL (90 mg) of calf lung surfactant extract instilled into their trachea before the first breath; control infants received 3 mL of normal saline. A prospective scoring system and respiratory support variables were used to compare the groups. At 48 hours of age, only two of 14 calf lung surfactant extract-treated infants (14%) had hyaline membrane disease compared with seven of 13 control infants (54%) (P = .033). Inspired oxygen, mean airway pressure, ventilator rate and ventilator efficiency index were also lower in the treated group during the first 48 hours of life (P < .01 to P < .001). Calf lung surfactant extract instillation at birth appears to be an effective material and method of preventing hyaline membrane disease in extremely premature infants.

Single Dose Treatment of Trichomoniasis

1982 ◽  
Vol 10 (2) ◽  
pp. 129-130 ◽  
Author(s):  
G Gabriel ◽  
E Robertson ◽  
R N T Thin
Keyword(s):  
Single Dose ◽  
Trichomonas Vaginalis ◽  
Controlled Trial ◽  
Oral Treatment ◽  
Controlled Study ◽  
Cure Rate ◽  
Double Blind ◽  
High Single Dose ◽  
Single Blind ◽  
Single Dose Treatment

Oral treatment for trichomonas vaginalis infection is now well established. In a previous paper, we established the value of a high single dose regimen of metronidazole for this condition by demonstrating its efficacy in a double-blind controlled study. Tinidazole is another accepted trichomonacide. By means of a single-blind controlled trial, we demonstrate that a 2 g single dose of tinidazole is as effective as a 2 g single dose metronidazole in the treatment of vaginal trichomoniasis. The cure rate for tinidazole was 95% and for metronidazole it was 97·5%. No side-effects were reported with either regimen.

scholarly journals Baloxavir Marboxil Single-dose Treatment in Influenza-infected Children

2020 ◽  
Vol 39 (8) ◽  
pp. 700-705 ◽  
Author(s):  
Jeffrey Baker ◽  
Stanley L. Block ◽  
Balpreet Matharu ◽  
Laura Burleigh Macutkiewicz ◽  
Steffen Wildum ◽  
...  
Keyword(s):  
Single Dose ◽  
Dose Treatment ◽  
Single Dose Treatment

ARTIFICIAL VENTILATION IN HYALINE MEMBRANE DISEASE: THE USE OF POSITIVE END-EXPIRATORY PRESSURE AND CONTINUOUS POSITIVE AIRWAY PRESSURE

PEDIATRICS ◽  
1973 ◽  
Vol 51 (4) ◽  
pp. 629-640
Author(s):  
Niloufer Cumarasamy ◽  
Rosmarie Nüssli ◽  
Dieter Vischer ◽  
Peter H. Dangel ◽  
Gabriel V. Duc
Keyword(s):  
Mechanical Ventilation ◽  
Survival Rate ◽  
Continuous Positive Airway Pressure ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Artificial Ventilation ◽  
Controlled Trial ◽  
Hyaline Membrane Disease ◽  
Positive End Expiratory Pressure ◽  
Hyaline Membrane

During the years 1969, 1970, and 1971, 120 infants with hyaline membrane disease were studied, of whom 71 were treated with artificial ventilation. Among other changes in 1971, positive end-expiratory pressure was applied during mechanical ventilation and continuous positive airway pressure maintained during the weaning period. The survival rate of the ventilated babies increased from 23% in the preceding two years to 70% in 1971. As this study is not a controlled trial, the observed increase in survival cannot be ascribed to the application of increased airway pressure alone. The data presented, though necessarily inconclusive, may be useful for continuing comparisons with other pediatric centers.

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